Neurology
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Evaluating CT Perfusion and Angiography as Ancillary Tests for Brain Death Diagnosis: Insights from a Multicenter Canadian Study
A large Canadian prospective study assessed brain CT perfusion and angiography for confirming death by neurologic criteria, highlighting high sensitivity but suboptimal specificity, emphasizing cautious use alongside clinical examination.
Regional Specificity of Layer 3 Dendritic Spine Deficits in Schizophrenia: Implications for Cortical Circuit Dysfunction
This study reveals region- and size-specific dendritic spine deficits in cortical layer 3 neurons of schizophrenia patients, highlighting differential synaptic disruptions across visual and prefrontal cortical areas underpinning cognitive d
Long-Term Outcomes of Extracranial Vertebral Artery Reconstruction in Managing Symptomatic Vertebral Artery In-Stent Restenosis or Occlusion
This study evaluates the efficacy of vertebral artery reconstruction surgery versus medical therapy in reducing stroke recurrence and improving neurological outcomes over a ten-year period.
Long-Term Unmet Needs and Rehabilitation Gaps: Impacts on Stroke Survivors’ Quality of Life in Korea
This study highlights how long-term unmet needs and rehabilitation deficits adversely affect the quality of life among stroke survivors in South Korea, emphasizing the need for community-based support systems.
Addressing Disparities in Post-Stroke Community Rehabilitation: Insights from the COMPASS Study
This article analyzes recent findings on sociodemographic and geographic disparities in community-based stroke rehabilitation from the COMPASS trial.
Electroacupuncture in Ischemic Stroke: Integrating Preclinical Evidence into Clinical Potential
This review synthesizes preclinical evidence on electroacupuncture’s mechanisms in ischemic stroke, highlighting its therapeutic potential and factors influencing efficacy.
Long-Term Seizure Outcomes and Epilepsy Risk in Anti-LGI1 Encephalitis: Insights from a Multicenter Cohort Study
This study assesses seizure remission and epilepsy risk in 236 anti-LGI1 encephalitis patients, highlighting immunotherapy’s role in seizure control and identifying biomarkers linked to persistent cognitive impairment and long-term outcomes
Long-Term Success of Satralizumab in Managing NMOSD: Insights from the SAkuraMoon Study
This article reviews the long-term safety and efficacy of satralizumab in neuromyelitis optica spectrum disorder based on the SAkuraMoon extension trial.
ESCAPE-NEXT Trial: Nerinetide Fails to Improve Functional Outcomes in Acute Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy Without Prior Thrombolysis
The ESCAPE-NEXT trial evaluated nerinetide for acute ischaemic stroke patients undergoing thrombectomy without prior thrombolysis. Nerinetide showed no significant improvement in functional outcomes or safety concerns, highlighting the need
Long-Term Stroke Risk in Healthy Women: The Predictive Role of hsCRP, LDL Cholesterol, and Lipoprotein(a)
A 30-year prospective study reveals that elevated hsCRP, LDL cholesterol, and lipoprotein(a) levels independently and collectively increase the risk of ischaemic stroke in healthy women, advocating for early biomarker screening in stroke pr
Persistent Olfactory Dysfunction Following SARS-CoV-2 Infection: Insights from the RECOVER Adult Cohort
A large prospective study demonstrates that olfactory dysfunction is prevalent and often clinically unrecognized long after SARS-CoV-2 infection, highlighting the value of formal smell testing in patient care and cognitive risk assessment.
Severe Symptomatic Arterial Vasospasm Following Pituitary Surgery: A Rare Case and Systematic Review of the Literature
We report a rare case of severe symptomatic arterial vasospasm after pituitary surgery, accompanied by a systematic review highlighting risk factors, clinical presentation, treatment strategies, and outcomes for this life-threatening compli
Evaluating Telestroke’s Impact on Acute Ischemic Stroke Treatment Timeliness and Outcomes
Telestroke evaluation increases thrombolysis rates but is associated with longer treatment times and delays in patient transfers in acute ischemic stroke, highlighting the need to address modifiable treatment delays.
Early Intravenous Immunoglobulin Therapy Improves Long-Term Outcomes in Anti-IgLON5 Disease
This retrospective multicenter study found that early intravenous immunoglobulin treatment in anti-IgLON5 disease is linked to reduced disability and mortality, highlighting a promising immunotherapeutic strategy for this rare autoimmune en
Impact of Early Extracranial Surgery on One-Year Outcomes After Traumatic Brain Injury: Insights from the TRACK-TBI Study
Early extracranial surgery following moderate-severe traumatic brain injury or positive CT findings is linked to worse cognitive, functional, and quality of life outcomes at one year, highlighting the need to refine surgical timing and post
Evaluating Electromagnetic Network-Targeted Field Therapy for Post-Ischemic Stroke Disability: Insights from the EMAGINE Trial
The EMAGINE randomized clinical trial assessed low-intensity electromagnetic stimulation combined with rehabilitation in moderate to severe ischemic stroke patients. While safe, it did not yield statistically significant functional improvem
Transcutaneous Peripheral Nerve Stimulation for Essential Tremor: Advancements from a 2024 Randomized Clinical Trial and Evolving Evidence
AI-driven transcutaneous peripheral nerve stimulation (TPNS) shows significant improvements in upper limb function for essential tremor (ET), supporting a promising noninvasive treatment approach with manageable safety profile over 90 days.
Oral Valiltramiprosate in APOEε4/ε4 Carriers with Early Alzheimer’s Disease: Insights from the Phase III APOLLOE4 Trial
This phase III trial evaluated oral valiltramiprosate in APOEε4/ε4 homozygotes with early Alzheimer’s, showing brain atrophy slowing but limited overall clinical benefit, with nominal improvements in mild cognitive impairment subgroups.
Amygdala Tau Pathology as a Key Contributor to Depressive Symptoms in Aging: Insights from Neuroimaging Studies
Amygdala tau accumulation in cognitively normal older adults correlates with worsening depressive symptoms, especially in APOE ε4 carriers, highlighting its role in neuropsychiatric changes during aging.
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