Neurology
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Two-Year 40 Hz Audiovisual Stimulation in Mild Alzheimer’s: Safety, EEG Entrainment, and Early Biomarker Signals
An open-label two-year extension in five patients with mild Alzheimer’s disease found daily 1‑hour 40 Hz audiovisual stimulation to be safe, produced sustained EEG gamma entrainment in late‑onset cases, and was associated with smaller cogni
Do Vascular Pathways Explain How Lifestyle Affects Dementia Risk? A Critical Look at the Evidence
A scoping review found sparse and inconsistent mediation analyses assessing cardiovascular disease as the pathway linking lifestyle factors to cognition; evidence is tentative for physical activity but urgent, better-designed studies are ne
Contactless In-Home Longitudinal Monitoring of Night-Time Sleep Patterns and Physiology in Aging and Alzheimer’s Disease
This review synthesizes evidence on contactless, longitudinal sleep monitoring revealing Alzheimer’s disease-specific nocturnal behaviors and introduces the DRI-SI-AD digital biomarker for tracking dementia progression.
Balance, Not Bedrest: Daily Movement Patterns Linked to Faster Symptom Recovery After Pediatric Concussion
Compositional analysis of the PedCARE cohort suggests that an early period of relative rest combined with above-average light and moderate-to-vigorous activity over the first two weeks is associated with lower postconcussion symptom burden
Microbiota, 3‑Hydroxyanthranilic Acid and Dopaminergic Signalling: A New Pathway Linking Obesity to Attention Deficits
A multi-cohort human study with mouse and Drosophila validation implicates gut microbes and the tryptophan metabolite 3‑hydroxyanthranilic acid in modulating attention in obesity, suggesting microbiota-directed interventions could improve c
Lacosamide Lowers Peripheral Nerve Excitability in Large Myelinated Fibers: Randomized Crossover Evidence and Biomarker Implications
A randomized, double‑blind crossover trial in healthy volunteers found lacosamide acutely reduced strength–duration time constant and other excitability metrics in large myelinated peripheral fibers; pregabalin and tapentadol produced no co
Pregabalin Restores Sleep and Circadian Rhythms in Neuropathic Pain—Unlike Morphine: Translational Insights from a Mouse SNI Model
In a mouse spared nerve injury model, pregabalin—but not morphine—restored REM sleep, normalized locomotor and temperature circadian rhythms, and reversed spinal circadian gene changes. Findings suggest analgesic choice can differentially a
Efgartigimod Shows Benefit in AChR‑Antibody–Negative Generalized Myasthenia Gravis — New Data from ADAPT SERON
Phase 3 ADAPT SERON data show efgartigimod improves MG‑ADL scores in AChR‑Ab–negative gMG, with pronounced benefit in MuSK‑positive patients; results for triple‑seronegative disease were inconclusive. Safety profile was consistent with prio
Persistent Depressive Symptoms After MCI Strongly Predict Progression to Alzheimer’s Disease
In an ADNI longitudinal cohort, persistently elevated depressive symptoms over 36 months after MCI diagnosis were associated with a dose‑dependent, substantially higher hazard of conversion to Alzheimer’s disease over long-term follow-up.
Higher Vitamin B12 from Mid- to Late Life Is Associated with Slower Cognitive Decline: Evidence and Implications
Elevated vitamin B12 levels from mid- to late life correlate with reduced rates of cognitive decline across language, memory, and executive function domains, independent of folate status, highlighting potential preventative strategies again
APOE ε4, Age and Sex Converge to Disturb Anterior Olfactory Nucleus Physiology: Electrophysiologic Evidence for Early Alzheimer’s Vulnerability
In vivo awake recordings in transgenic mice show APOE ε4 reduces neuronal excitability in the anterior olfactory nucleus (AON); adult females are more excitable than males (a sex difference lost with aging), while aging amplifies network os
Tau Links Amyloid and Vascular Burden to Faster Clinical Decline: Chronicity Reveals Synergy Between White Matter Injury and Amyloid in Dementia Progression
Longer years above amyloid and white matter hyperintensity positivity predict faster clinical decline. White matter vascular burden amplifies amyloid-related progression, and tau accumulation mediates this effect, highlighting targets and t
Subclinical Vascular Burden Predicts 20‑Year Cognitive Decline: Arteriosclerosis and Atherosclerosis Outperform Blood Pressure and Cardiac Measures
In MESA, baseline subclinical arteriosclerosis and atherosclerosis scores predicted greater cognitive decline and higher odds of MCI/dementia over 20 years, independently of clinical dementia risk factors.
New International Research Recommendations on Sleep and Circadian Measures in Aging and Alzheimer’s Disease
An expert Delphi consensus from ISTAART lays out core data, methods and research priorities to harmonize sleep and circadian studies in aging and Alzheimer’s disease.
Diabetes and Dementia Biomarkers: Less Alzheimer’s Pathology but More Non‑AD Neurodegeneration in Cognitively Normal Adults
A pan‑European analysis (n=5,550) found diabetes was associated with lower odds of amyloid and p‑tau pathology in cognitively impaired patients, but with markers of neurodegeneration (total tau, medial temporal atrophy) in cognitively norma
Baseline Penumbral Oxygen Extraction Fraction Predicts Infarct Growth Despite Successful Reperfusion
In patients with anterior large‑vessel stroke who achieved successful reperfusion, lower penumbral oxygen extraction fraction (OEFr) on baseline DSC‑MRI independently predicted substantial infarct growth and greater penumbra-to-infarct conv
Depression, Anxiety and PTSD Associated With Earlier Onset of Alzheimer’s Disease: Psychiatric Burden Lowers Age at Symptom Onset
In two large Alzheimer cohorts, a history of depression, anxiety, or PTSD and an increased number of psychiatric comorbidities were associated with earlier age at AD symptom onset by up to ~7–8 years for multi-morbidity.
Circadian Dysregulation and Executive Dysfunction in Wolfram Syndrome: Toward Chrono‑Diagnosis and Chronotherapy
Emerging evidence links WFS1-driven ER stress to serotonergic/cholinergic disruption, executive dysfunction, and circadian dysregulation in Wolfram syndrome. This article synthesizes recent data, outlines chrono‑informed clinical assessment
Obesity Alters Symptom Trajectory and Inflammatory Signatures after Sport-Related Concussion: the NCAA‑DoD CARE Consortium
In a large prospective cohort, obese BMI (≥30) was associated with worse post-concussion neurocognitive outcomes and a persistently proinflammatory blood biomarker profile, despite fewer baseline symptoms. Findings suggest obesity modifies
Neuromuscular Training Substantially Improves Athletes’ Balance: A Meta-Analysis with Practical Takeaways
A 2025 meta-analysis of 13 trials found neuromuscular training produced large improvements in athletes’ balance (overall SMD 1.47), with benefits for both static and dynamic domains. Results support incorporating targeted neuromuscular prog
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