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The Earlier, the Better: INTERACT Pooled Analysis Confirms 3-Hour Golden Window for Intensive Blood Pressure Lowering in Acute ICH

MedXY Editorial Team•Dec 23, 2025•Emergency Medicine
HypertensionIntracerebral Hemorrhagestroke

Highlights

A comprehensive pooled analysis of four major INTERACT trials involving 11,312 patients confirms that intensive systolic blood pressure (SBP) lowering to a target of less than 140 mmHg is safe and significantly improves functional outcomes in acute intracerebral hemorrhage (ICH).

Key findings indicate that the efficacy of intensive BP lowering is highly time-dependent, with the greatest benefits for functional recovery and the prevention of hematoma expansion occurring when treatment is initiated within 3 hours of symptom onset.

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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