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An Australian cohort study found that prenatal exposure to valproate, levetiracetam, topiramate, and carbamazepine was associated with poorer cognitive outcomes in children, while lamotrigine exposure was not.
Plasma %p-tau217 plus eMTBR-tau243 showed strong agreement with amyloid/tau PET staging, tracked clinical severity, and aligned with neuropathology, supporting a scalable blood-based approach to Alzheimer disease biological staging.
In a nationwide Swedish cohort, several adverse pregnancy outcomes were linked to higher long-term maternal risk of subarachnoid hemorrhage, supporting pregnancy as an early vascular stress test.
A national U.S. study found that patients with epilepsy from rural counties had worse hospital outcomes, including higher mortality, more status epilepticus, longer stays, and less EEG use, highlighting access-related disparities.
In a phase 3 randomized withdrawal trial, ecopipam maintained tic improvement in pediatric Tourette syndrome over 24 weeks and showed a generally favorable safety profile without clinically meaningful weight, metabolic, or drug-induced move
This phase 3 trial found that ecopipam reduced tic relapse and maintained symptom improvement in children and adolescents with Tourette syndrome, with mainly central nervous system side effects and no major weight or metabolic concerns.
In a Swedish randomized trial, low-dose acetazolamide did not improve gait in patients with idiopathic normal pressure hydrocephalus and caused more side effects than placebo, arguing against routine use as medical therapy.
In a nationwide Medicare cohort, chronic wildfire smoke PM2.5 exposure was associated with a modest but significant increase in incident stroke, with stronger effects over longer exposure windows.
The AHA-proposed CRIS classification reclassified many cancer-associated strokes previously labeled cryptogenic and identified a subgroup with markedly worse survival, improving both etiologic clarity and prognostic stratification.
In the HUNT Study, higher midlife waist-to-height ratio and BMI predicted higher late-life plasma p-tau217 and biomarker-verified Alzheimer dementia, whereas higher adiposity in late life was associated with lower biomarker levels and lower
In a randomized trial of large-vessel-occlusion stroke, standard-dose tenecteplase improved early reperfusion before thrombectomy compared with low-dose alteplase, with similar safety and functional outcomes.
In patients with large-vessel-occlusion stroke undergoing thrombectomy, standard-dose tenecteplase achieved more early reperfusion than low-dose alteplase, with similar safety and functional outcomes.
A genome-wide association study identified CNIH4, CCNG1, and RHOJ as genetic modifiers of autosomal dominant Alzheimer’s disease, with associations spanning disease risk, age at onset, fluid biomarkers, and neuroimaging phenotypes.
A 2026 Mendelian randomization study supports high BMI as a causal risk factor for vascular-related dementia, with part of the effect mediated through elevated systolic and diastolic blood pressure.
A 2026 Ophthalmology report identified a pain-predominant dry eye phenotype in 6.9% of patients, marked by high symptom burden, minimal surface signs, and enrichment for migraine and psychiatric comorbidity.
In OPTIMAL-BP 1-year follow-up, targeting systolic BP <140 mm Hg after successful thrombectomy was associated with worse long-term functional recovery than conventional BP management.
In rural Germany, GP-based teleneurology reduced direct neurology referrals but increased referrals to other specialists and hospitals, suggesting better triage rather than substitution of secondary care.
Older stroke patients treated in rural hospitals received less inpatient rehabilitation and more skilled nursing facility care than urban patients, with fewer days at home over 1 year but similar overall mortality.
A new study suggests vamorolone may preserve motor benefits seen with standard steroids in Duchenne muscular dystrophy while better protecting growth, though weight gain remains a concern.
A randomized clinical trial found that electroacupuncture reduced pain more than sham treatment in postherpetic neuralgia, with benefits lasting at least one month and no major safety concerns.
