Neurology
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Molecular Interplay of TREM2 and ApoE Variants in Alzheimer’s Disease: Structural Insights and Therapeutic Implications
This article elucidates how TREM2-apoE3 interactions are structurally altered by Alzheimer’s-associated TREM2 R47H and apoE4 variants, revealing potential mechanisms that contribute to disease risk and informing therapeutic targeting strate
APOE ε4 Allele as an Independent Predictor of Survival in Parkinson’s Disease Patients
The APOE ε4 allele significantly reduces survival in Parkinson’s disease patients independently of dementia, linked to mitochondrial dysfunction and ER stress in PD models.
Obicetrapib’s Role in Modulating Alzheimer’s Disease Biomarkers in Patients with Cardiovascular Disease: A Landmark Clinical Study
Obicetrapib, a CETP inhibitor, lowers Alzheimer’s biomarkers like p-tau217 in ASCVD patients, especially ApoE4 carriers, suggesting a potential preventive strategy for high-risk individuals.
Pregnancy Hypertension and Elevated p-tau217: A Midlife Indicator of Alzheimer’s Disease Risk in Women
Pregnancy hypertension is independently associated with higher serum p-tau217 levels in midlife women, suggesting a link to preclinical Alzheimer’s disease pathology and potential for early screening and intervention.
Comparative Performance of Dementia Risk Indices in the HUNT Study: Insights into CogDrisk, LIBRA, CAIDE, and More
This study compares five dementia risk indices using data from the HUNT study, revealing CogDrisk as the most accurate predictor, though none outperformed a demographics-only model including age and education.
Rapamycin for Alzheimer’s Prevention in APOE4 Carriers: Restoring Brain Metabolism and Vascular Health
Rapamycin shows promise in preventing Alzheimer’s disease in APOE4 carriers by improving brain mitochondrial function, synaptic activity, and vascular health, highlighting a potential genotype-targeted early intervention for this high-risk
APOE4 Amplifies Blood Biomarkers’ Association with Cognitive Decline in Aging Adults: Insights from a Biracial 20-Year Cohort Study
This study reveals that APOE4 carriers with elevated blood neurodegenerative biomarkers experience accelerated cognitive decline, highlighting the gene’s role in exacerbating neurodegeneration among community-dwelling older adults without d
APOE ε4 Allele: A Key Driver of Cognitive Decline and Neurodegeneration in Older Adults from the Democratic Republic of the Congo
This study reveals that the APOE ε4 allele is linked to increased dementia prevalence, cognitive deficits, brain atrophy, and plasma biomarkers of neurodegeneration in older adults in the DRC, emphasizing its critical role in African popula
Lifetime Walking Intensity and Duration Reduce Amyloid-β Accumulation in Alzheimer’s Disease: Insights from a Korean Longitudinal Cohort
A 4-year longitudinal study reveals that long-duration, high-intensity lifetime walking is associated with reduced amyloid-β accumulation in older adults, suggesting a neuroprotective effect when initiated early in life.
Moderate-to-Vigorous Physical Activity, p-tau181, and Cognition in Older Adults with Memory Complaints: Insights from the MAPT Study
Higher moderate-to-vigorous physical activity slows p-tau181 increase, a marker of Alzheimer’s pathology, but elevated p-tau181 diminishes exercise-related cognitive benefits in older adults.
Evaluating Combined Mind-Body Exercise, Cognitive Training, and Nurse-Led Risk Factor Modification in Mild Cognitive Impairment: Insights from a Three-Arm Randomized Controlled Trial
A large RCT in primary care showed no significant cognitive benefits of a combined intervention integrating mind-body physical exercise, cognitive training, and nurse-led risk factor modification over nurse-led risk factor modification alon
Blood Biomarkers of Alzheimer’s Disease Predict Long-Term Muscle Strength Decline in Older Adults
This study links Alzheimer’s disease-related blood biomarkers with accelerated muscle strength loss over 12 years, highlighting the interplay between neurodegeneration and physical decline in aging populations.
Evolving Landscape of Modifiable Dementia Risk Factors in Australia: Socioeconomic and Sex Disparities Over 15 Years
This analysis reveals stable dementia risk fractions despite changing risk profiles over 15 years in Australia, highlighting greater modifiable risk among low-income groups and males, with depression emerging as a leading factor in mid-life
Dietary Patterns and Dementia Risk: Insights from a Large UK Biobank Cohort Study
Higher adherence to Mediterranean, MIND, and Recommended Food Score diets is linked to reduced risk of all-cause dementia and Alzheimer disease, highlighting diet as a modifiable factor in dementia prevention.
Age-Dependent Impact of Vascular Risk Factors on Acute Stroke: Insights from the INTERSTROKE Study
The INTERSTROKE study reveals how age modifies the relationship between vascular risk factors and acute stroke, highlighting age-specific prevention priorities to reduce stroke burden globally.
Advances in Alzheimer’s Diagnosis: A Comprehensive Review of CSF and Blood Biomarkers
This article reviews a systematic meta-analysis of 15 cerebrospinal fluid and blood biomarkers for Alzheimer’s disease, highlighting robust diagnostic performance of core markers T-tau, P-tau, and Aβ42 in clinical practice and research.
Assessing the Role of Kidney Function in Alzheimer’s Disease Blood Biomarker Interpretation and Amyloid-β Positivity Prediction
Kidney function influences certain Alzheimer’s disease blood biomarker levels but, within normal to mild impairment ranges, does not improve prediction of amyloid-β positivity, supporting the clinical utility of blood biomarkers in AD diagn
Unraveling Blood-Based Biomarkers in Neurodegenerative Diseases: Insights from the Young Finns Study on Intergenerational and Metabolic Influences
This cohort study from the Young Finns Study elucidates factors influencing blood-based biomarkers for neurodegenerative diseases, highlighting age, APOE ε4 genotype, kidney function, metabolic parameters, and notable intergenerational asso
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