Neurology
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Life Course Air Pollution Exposure Linked to Cognitive Decline and Brain Structural Changes in Older Adults
A population-based study reveals that midlife exposure to air pollutants such as nitrogen dioxide and particulate matter is associated with cognitive decline and brain structural alterations by age 69-71, highlighting long-term neurological
Life Course Air Pollution Exposure and Cognitive Decline: Insights from the 1946 British Birth Cohort
This population-based study reveals that midlife exposure to nitrogen dioxide and particulate matter correlates with poorer cognitive function and adverse brain structural changes in later life, underscoring the neurocognitive risks of air
Iyengar Yoga and Fall Risk in Older Adults: Unexpected Outcomes from a Rigorous RCT
A large randomized controlled trial found that an Iyengar yoga-based exercise program increased fall rates among older adults compared to seated relaxation yoga, despite improvements in physical activity and balance confidence, highlighting
Optimizing Lifestyle Interventions to Prevent Cognitive Decline in Older Adults: Insights from a Comprehensive Network Meta-Analysis
A large-scale network meta-analysis highlights that combined physical exercise and cognitive training most effectively improve cognition in older adults without impairment, emphasizing tailored lifestyle strategies for dementia prevention.
Mid-to-Late-Life Smoking Cessation Slows Long-Term Cognitive Decline: Insights from a 12-Country Longitudinal Study
Smoking cessation in middle-aged and older adults is linked to a slower decline in memory and fluency over six years, suggesting quitting smoking benefits long-term cognitive health regardless of age at cessation.
Revolutionizing Spinocerebellar Ataxia Assessment: The Novel Digital Composite Balance Score SIBA
The Score of Integrated Balance in Ataxia (SIBA) is a newly developed digital composite score that accurately measures standing and walking balance in spinocerebellar ataxia, enabling smaller, more efficient clinical trials with improved se
Emerging Threat: Active West Nile Virus Transmission in Brazil Reveals Critical Public Health Challenge
Recent evidence confirms active West Nile virus transmission across Brazil with significant neurological impact and fatalities, emphasizing the need for enhanced surveillance and public health action in South America.
Predicting Seizure Recurrence After a First Unprovoked Seizure: Key Prognostic Factors and Clinical Implications
This article examines prognostic factors predicting seizure recurrence after a first unprovoked seizure in children and adults, highlighting the roles of EEG abnormalities, brain imaging, nocturnal seizures, and family history, while addres
Harnessing Combined Immersive and Nonimmersive Virtual Reality with Mirror Therapy in Stroke Rehabilitation: Evidence from a Systematic Review and Meta-Analysis
Moderate-quality evidence from 14 RCTs supports combined immersive and nonimmersive VR with mirror therapy to enhance upper extremity function and hand dexterity in stroke survivors, though clinical significance needs cautious interpretatio
Enhancing Care for Dementia: The Impact of Dementia Literacy Interventions on Caregivers
A meta-analysis shows that dementia literacy interventions significantly reduce caregiver burden and improve knowledge, attitudes, and self-efficacy among caregivers of people with dementia.
Brexpiprazole in Alzheimer’s Disease-Related Agitation: Modest Gains Amidst Safety Uncertainties
This review evaluates brexpiprazole’s efficacy and safety for agitation in Alzheimer’s disease, revealing modest symptom improvement but uncertain safety profiles, underscoring the need for individualized therapy and further research.
Probiotics and Cognitive Health: Evaluating the Evidence from Systematic Reviews and Meta-Analyses
An umbrella review synthesizes evidence from 156 RCTs assessing probiotics’ effects on cognitive-related outcomes, showing moderate- to high-quality support for cognitive benefits but highlighting need for further trials on strains and dosi
Alzheimer’s Disease: Navigating Controversies and Shaping Future Strategies
Recent advances in anti-β amyloid monoclonal antibodies offer promising reductions in Alzheimer’s disease progression but spark debate regarding their clinical impact, cost-effectiveness, and accessibility. Emerging biomarkers and preventiv
Simvastatin Fails to Slow Disability Progression in Secondary Progressive Multiple Sclerosis: Insights from the Phase 3 MS-STAT2 Trial
In a large phase 3 trial, simvastatin 80 mg daily did not reduce disability progression in secondary progressive multiple sclerosis, challenging prior phase 2 results and underscoring the complexity of neurodegeneration in SPMS.
Decoding SUDEP: Key Risk Markers and the Role of Peri-Ictal Apnoea in Epilepsy Mortality
A decade-long prospective study identifies living alone, convulsive seizure frequency, and peri-ictal apnoea as pivotal predictors for sudden unexpected death in epilepsy (SUDEP), highlighting the potential of cardiorespiratory monitoring i
How Poor Sleep Accelerates Brain Aging: The Role of Inflammation and What You Can Do
New research links poor sleep quality in middle-aged and older adults to accelerated brain aging, with inflammation playing a key role. Improving sleep may help slow cognitive decline and promote brain health.
Transcutaneous Auricular Vagus Nerve Stimulation: A Promising New Therapy for Erythematotelangiectatic Rosacea
A randomized trial demonstrates that 3 weeks of transcutaneous auricular vagus nerve stimulation significantly reduces facial erythema, flushing, and associated neuropsychiatric symptoms in erythematotelangiectatic rosacea, with effects per
Aspirin Use in Older Adults: Insights from the ASPREE-XT Study on Healthy Lifespan
Extended follow-up from the ASPREE-XT study shows low-dose aspirin does not improve healthy lifespan—defined as survival free of dementia, persistent disability, or death—in healthy older adults, and its risks include increased major hemorr
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