Section
This study unveils tofersen’s distribution and potent SOD1 reduction within the CNS of SOD1-ALS patients, utilizing autopsy tissues from clinical trial participants, confirming anticipated pharmacokinetic and pharmacodynamic effects.
A phase 3 randomized, placebo-controlled crossover trial demonstrates that levacetylleucine significantly improves neurological function in ataxia-telangiectasia patients with a favorable safety profile.
Mobile Stroke Units enable faster diagnosis and initiation of antihypertensive treatment in intracerebral hemorrhage, significantly reducing time to care compared with conventional EMS transportation.
This study reveals a spatiotemporal relationship between cortical microinfarcts and cortical superficial siderosis in cerebral amyloid angiopathy, suggesting that superficial siderosis may promote local ischemic injury and highlighting a po
This study characterizes neurological complications in adult Ebola survivors over 7 years, demonstrating persistent cognitive and neuropsychiatric deficits despite gradual improvement, underscoring the need for ongoing neurological follow-u
A nationwide randomized trial shows decompressive craniectomy does not improve functional outcomes over standard craniotomy but increases delayed intracranial hemorrhage risk in patients with large acute epidural hematoma and tentorial hern
This study reveals that disability improvement and worsening independent of attacks, though rare, occur in AQP4-IgG+ NMOSD and MOGAD. Early attack prevention and younger age are key factors influencing disability trajectories.
A multicenter randomized trial shows that middle meningeal artery embolization with n-butyl cyanoacrylate, adjunct to standard care, significantly reduces recurrence and reoperation rates in chronic subdural hematoma without increasing adve
This review synthesizes evidence on staged, bilateral MRgFUS pallidothalamic tractotomy for Parkinson’s motor complications, highlighting demonstrated unilateral safety and modest bilateral efficacy with increased adverse events, unde
AI-enabled point-of-care EEG monitoring accurately measures seizure burden, showing a dose-dependent association with unfavorable clinical outcomes at discharge, highlighting its potential in critical care.
A pooled individual participant data meta-analysis demonstrates that Electromagnetic Network-Targeted Field (ENTF) neuromodulation significantly improves freedom-from-disability and reduces poststroke disability compared to sham treatment,
This study develops a comprehensive probabilistic atlas of brain function using extraoperative electrocortical stimulation mapping in epilepsy patients, revealing distributed and variable language and motor cortical organization beyond trad
This review examines the impact of traumatic brain injury on the accuracy of Alzheimer disease blood biomarkers, highlighting reduced diagnostic performance in TBI-affected populations and the implications for clinical interpretation.
Rare deleterious variants in FBN2 gene contribute to spontaneous spinal CSF leaks, expanding our understanding of connective tissue involvement and opening paths for genetic testing and tailored therapies.
This study reveals that dementia in severe, treatment-resistant schizophrenia exhibits a unique cognitive profile distinct from common neurodegenerative dementias and lacks typical genetic markers such as APOE4, highlighting a novel dementi
Selective local management of mild traumatic brain injury with intracranial hemorrhage shows comparable safety and outcomes to transfer to level I trauma centers, reducing unnecessary patient transfers.
The left atrial to ventricular volume ratio (LA:LV ratio) emerges as a superior marker over left atrial volume index (LAVi) for atrial cardiopathy, showing stronger association with ischemic stroke risk, cognitive decline, and atrial fibril
Incidental DWI-positive lesions are prevalent in cerebral amyloid angiopathy and CADASIL, showing disease-specific distributions and associations with neurodegeneration and MRI biomarkers. These findings underscore their potential role as m
Machine learning analysis of brief patient-physician conversations using acoustic speech features can effectively screen for cognitive impairment in primary care settings, enabling scalable early detection.
Secondary analysis of the TEMPO-2 trial reveals that successful recanalization significantly improves 90-day functional outcomes in minor ischemic stroke patients with proven occlusion, with tenecteplase markedly enhancing recanalization ra
