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A multicenter study reveals that nearly one-quarter of patients meeting the newest multiple sclerosis criteria for optic neuritis actually have MOGAD or NMOSD, emphasizing the critical role of antibody screening and detailed orbital MRI in
The Phase 2b PARADIGM trial reveals that PrimeC, a novel oral combination therapy, is safe and significantly slows functional decline and reduces the risk of death or hospitalization in ALS patients over 18 months.
A retrospective study of 489,360 patients reveals that right-sided middle cerebral artery strokes are associated with significantly higher inpatient mortality and complications compared to left-sided strokes, likely due to inherent scoring
This review synthesizes findings on how periventricular white matter hyperintensities (PWMHs) drive cognitive impairment in Aβ-negative individuals through distinct metabolic mediation and direct structural pathways, highlighting the clinic
This randomized pilot study demonstrates that high-frequency TENS significantly improves specific neuropathic ocular pain symptoms over three months, offering a non-invasive, non-pharmacological alternative for patients with refractory ocul
A comprehensive review of a multicenter RCT (Morone et al., 2026) demonstrating that exoskeleton-based robot-assisted therapy significantly improves upper limb motor impairment and clinical outcomes in the early subacute phase of stroke rec
This study identifies somatic gene mutations in excitatory neurons of the motor cortex as a potential driver of sporadic ALS, challenging the traditional view of the disease’s genetic origins.
A large-scale analysis of the VA Million Veteran Program reveals that TBI, depression, and specific military environmental exposures significantly elevate the 10-year risk of Alzheimer’s and related dementias, highlighting critical targets
This review analyzes the ICSM Phase III study, highlighting how a structured empowerment program and standardized protocols in EMS significantly reduced prehospital delays and tripled alteplase administration rates for acute ischemic stroke
A study of 3,910 former college athletes found that a history of multiple concussions is significantly linked to worse mental health and sleep quality within five years of retirement, though most remain within normal clinical ranges.
A large-scale multicenter study reveals that persistent high-level Epstein-Barr nuclear antigen 1 (EBNA-1) peptide antibody titers serve as a highly specific biomarker, effectively distinguishing Multiple Sclerosis from other neuroinflammat
This review synthesizes findings from a national multicenter study identifying that hyperghrelinemia is a specific biomarker for Prader-Willi Syndrome, whereas other rare neurodevelopmental disorders exhibit normal ghrelin levels despite se
The BRAVO study provides critical evidence that while IV thrombolysis improves recovery in isolated vertebral artery occlusion, endovascular treatment may increase risks unless reserved for severe cases.
This review synthesizes recent evidence identifying PAICS downregulation as a critical link between C9orf72 loss-of-function, DNA repair failure, and cerebellar neurodegeneration, highlighting its potential as a therapeutic target.
A large-scale longitudinal study reveals that motor vehicle accidents cause significantly worse acute traumatic brain injury outcomes compared to falls. However, by one year post-injury, disability levels and community participation converg
This retrospective study identifies a high prevalence of spinal cord p-tau and protein copathologies in patients with Chronic Traumatic Encephalopathy (CTE), suggesting the existence of a ‘trauma-related encephalomyelopathy’ lin
This translational study demonstrates that the FKBP5 protein, a regulator of the stress response, significantly influences stroke outcomes. Lower FKBP5 levels correlate with smaller brain lesions in mice, while high-expression genetic varia
A prospective multicenter study reveals that the no-reflow phenomenon is a dynamic, evolving pathology following successful thrombectomy. It is significantly associated with infarct growth and poor functional outcomes, suggesting that achie
This review explores how paramagnetic rim lesions (PRLs), as markers of chronic active demyelination, serve as powerful predictors for clinical Multiple Sclerosis conversion in individuals with radiologically isolated syndrome.
This article synthesizes evidence from a large-scale individual participant data meta-analysis, demonstrating that early perihematomal edema growth (at 24 and 72 hours) is an independent predictor of death and disability after intracerebral
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