Elevated Cardiac Biomarkers Serve as Early Indicators of Structural Brain Damage and Cognitive Decline: Insights from the Hamburg City Health Study
Highlights
- High-sensitivity cardiac troponin I (hs-cTnI) and natriuretic peptides (NT-proBNP, MR-proANP) are independently associated with MRI-defined markers of brain aging.
- Elevated NT-proBNP is a significant predictor of reduced cortical thickness and impaired verbal memory.
- Structural brain changes, particularly in network connectivity and white matter integrity, mediate the relationship between cardiac health and cognitive performance.
- Monitoring cardiac biomarkers may serve as a low-invasive screening tool for early neurocognitive risk assessment in subclinical populations.
Background: The Heart-Brain Axis and Cognitive Longevity
MedXY registered readers
Sign in free to continue reading
Create or use your MedXY account to unlock the complete article.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.