Gastroenterology
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Diabetes, Male Sex, and Low HBsAg, HDV RNA, and ALT Predict Spontaneous HDV Suppression in Chronic Hepatitis D
In 1,610 untreated chronic hepatitis D patients, spontaneous HDV suppression was uncommon but increased over time. Diabetes, male sex, and lower baseline HBsAg, HDV RNA, and ALT predicted suppression and fewer liver-related events.
Targeting MLCK1 May Separate Immune Checkpoint Inhibitor Colitis From Antitumour Benefit
A Gut study identifies MLCK1-driven epithelial barrier failure as a central mechanism in immune checkpoint inhibitor colitis and suggests epicatechin as a barrier-protective strategy that preserves antitumour efficacy in preclinical models.
Should Some Colon Cancers Be Treated Before Surgery? What a New Trial Means for Patients
A major randomized trial found that chemotherapy before surgery did not improve 3-year disease-free survival in locally advanced colon cancer, but it still revealed important clues for more personalized treatment.
PBC-AIH Variant: New International Consensus Clarifies Diagnosis and Treatment
An international Delphi panel has standardized how to define, diagnose, and treat the PBC-AIH variant, emphasizing liver biopsy, periodic reassessment, and tailored immunosuppression for worse-risk patients.
KRAS-Driven CLDN18.2 O-GlcNAcylation Promotes Pancreatic Cancer Progression and Therapy Resistance
KRAS mutation and high glucose promote O-GlcNAcylation of CLDN18.2 in pancreatic cancer, pushing the protein off the cell membrane, boosting metastasis, and weakening CLDN18.2-targeted therapy. Low-dose MRTX1133 may restore sensitivity.
Non-contrast abbreviated MRI shows superior accuracy to ultrasound for hepatocellular carcinoma surveillance in cirrhosis: interim prospective trial results
A prospective trial found that non-contrast abbreviated MRI detected hepatocellular carcinoma in cirrhotic patients far better than ultrasound, with most MRI-detected tumors found at an early, potentially curable stage.
Sham-Controlled Trial Finds Translumbosacral Neuromodulation May Reduce Fecal Incontinence
In a sham-controlled trial, translumbosacral neuromodulation with 2400 or 3600 magnetic pulses reduced fecal incontinence episodes, improved severity scores and quality of life, and was well tolerated, with the higher dose showing the stron
A Body Surface Area–Adjusted Bevacizumab Target Was Linked to Better Survival in Atezolizumab-Treated Unresectable Hepatocellular Carcinoma
A nationwide Japanese real-world study suggests that a defined body surface area–adjusted bevacizumab exposure range may improve progression-free and overall survival in unresectable HCC treated with atezolizumab plus bevacizumab, without i
A Stromal CTHRC1 Biomarker Framework May Identify Colorectal Cancers With Poor Prognosis and Limited Immunotherapy Benefit
A large multiomic colorectal cancer study identifies CTHRC1-positive fibroblasts as a stromal biomarker linked to TGF-beta activity, adverse outcomes, and reduced checkpoint inhibitor benefit across both MSI and MSS disease.
低剂量聚乙二醇用于住院患者肠道准备的有效性：一项多中心随机试验
意大利多中心研究发现，1升聚乙二醇抗坏血酸方案在住院患者结肠镜检查前肠道准备中，高质量清洁率显著优于2升和4升方案，且患者耐受性更好。
Adherence to Surveillance in the Watch and Wait Approach for Rectal Cancer
Study finds 62% of rectal cancer patients on Watch and Wait receive optimal surveillance, with younger patients showing better adherence. Critical gaps occur in the first year, particularly in initial endoscopic/imaging exams and colonoscop
Gut Microbiome Signatures Improve Diagnosis and Prognostic Stratification in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma
A large shotgun metagenomic study links gut dysbiosis to EBV-associated nasopharyngeal carcinoma and shows that microbial markers, especially combined with EBV markers, may strengthen diagnosis and prognostic assessment.
A Simple Five-Variable Index Helps Identify Excess Alcohol Use in Steatotic Liver Disease When PEth Testing Is Not Readily Available
A new five-component biomarker panel, MAPI, showed consistent AUROC performance of about 0.75 for detecting MetALD-ALD and may help triage confirmatory PEth testing in steatotic liver disease.
Alpha-1-Antitrypsin Emerges as a Potential Salvage Option for Steroid- and Ruxolitinib-Refractory Gastrointestinal Acute GVHD
A 2026 single-center retrospective study suggests alpha-1-antitrypsin may offer favorable safety and encouraging activity in heavily pretreated gastrointestinal acute GVHD, though detailed outcome data and external validation remain essenti
Pairing HDV RNA With Anti-HDV Levels May Sharpen Staging and Treatment Monitoring in HBV/HDV Coinfection
In HBsAg-positive, anti-HDV-positive patients, combined measurement of HDV RNA and anti-HDV titers distinguished inactive from active disease and tracked interferon response more effectively than either marker alone.
AI Radiomics Detects Visually Occult Pancreatic Cancer on CT Nearly 16 Months Before Diagnosis and Outperforms Radiologists
A multi-institutional AI model identified pre-diagnostic pancreatic cancer on routine CT with meaningful lead time, higher sensitivity than radiologists, longitudinal stability, and externally validated specificity in a low-prevalence setti
Cancer Risk in Familial Adenomatous Polyposis Remains Broad Despite Preventive Surgery: Dutch Nationwide Data Highlight Rising Gastric Cancer Burden
A nationwide Dutch cohort confirms that patients with FAP remain at markedly elevated risk for multiple gastrointestinal and extraintestinal cancers, with gastric cancer emerging as the most frequently diagnosed malignancy since 2020.
Reversal of Roux-en-Y Gastric Bypass: A Swedish National Cohort Study
This nationwide Swedish study reveals that RYGB reversal is rare (0.3% of procedures) but effective for complications like abdominal pain and hypoglycemia. While 86% reported symptom improvement, significant complication risks require caref
HSP72-PRDX6 Control of PINK1 Ubiquitination Emerges as a New Mitophagy Axis in MASLD
A new Hepatology study identifies an HSP72–PRDX6 pathway that restores PINK1/Parkin mitophagy, reduces hepatic steatosis, and worsens MASLD when disrupted in mice and hepatocytes.
Uncoupling Metabolic Reprogramming in Hepatocellular Carcinoma: The JOSD1-PGAM1 Ubiquitination-Lactylation Switch
This article explores how the deubiquitinase JOSD1 drives HCC progression by modulating a novel PTM switch on PGAM1, promoting glycolysis and immune evasion while providing a new target for combined immunotherapy.
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