Gastroenterology
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Pathology-Driven Epithelial Sulfide Loss Reprograms the Redox Proteome and Triggers Barrett’s Esophagus
A study shows that reflux-related sulfide loss rewires esophageal redox proteins, increases PGE2 signaling, and helps drive Barrett’s esophagus, revealing a new potential therapeutic target.
Language Barriers and Treatment Delays Emerge as Modifiable Threats in Early-Onset Colorectal Cancer
A large Texas registry study found that treatment delays beyond 6 weeks were independently associated with worse survival in early-onset colorectal cancer, with language barriers identified as a potentially modifiable contributor.
Mailed Outreach for Colorectal Cancer Screening in Community Health Centers: CARES Pragmatic Cluster Randomized Clinical Trial
Mailed outreach improved colorectal cancer screening in community health centers, with FIT-DNA outperforming FIT. However, colonoscopy follow-up after abnormal stool tests remained low despite navigation support.
Machine Learning Clustering Reveals Distinct Phenotypes in Bilateral Hepatocellular Carcinoma
Machine learning identified two distinct bilateral hepatocellular carcinoma phenotypes with different tumor burdens, surgical approaches, and outcomes, suggesting preoperative risk stratification may improve patient selection and treatment
Y90 Radioembolization as a Bridge to Liver Transplantation in Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis
Y90 radioembolization downstaged about one-quarter of HCC patients with portal vein tumor thrombosis to transplant eligibility, and those who received liver transplantation had markedly better cancer-related outcomes and survival.
Quorum-Sensing Molecules Elevated in Long-Standing Ulcerative Colitis May Help Drive Colitis-Associated Cancer
Bacterial quorum-sensing molecules, especially C6-scAHL, were elevated in long-standing ulcerative colitis and promoted colon tumor growth in mice, suggesting a new microbiome-driven pathway for colitis-associated cancer.
Relaxing Diaphragmatic Incisions May Improve Symptom Outcomes in Difficult Hiatal Hernia Repair, but Morphologic Durability Remains Unproven
In complex redo and giant hiatal hernia repair, lateral diaphragmatic relaxing incisions were feasible and associated with favorable patient-reported symptom control at 24 months, although objective recurrence data are still lacking.
Role of Relaxing Lateral Incisions as an Add-On to Difficult Hiatal Repair in Redo and Giant Hernia Cases
A modified diaphragmatic relaxing incision technique may reduce tension during difficult redo and giant hiatal hernia repairs, with most patients reporting improved reflux symptoms and low postoperative symptom burden.
Pancreatic Cancer Risk During IPMN Surveillance Is About 10-Fold Higher Than in the General Population
A SEER-matched analysis found that patients undergoing IPMN surveillance have a markedly elevated malignancy risk, with substantial heterogeneity by duct dilation, obesity, age, and cyst features.
Pancreatic Cancer Risk During IPMN Surveillance: A SEER-Based Comparison
A SEER-based study found IPMN surveillance patients have about 10 times higher pancreatic cancer risk than the general population, with highest risk in those with main duct dilation or obesity.
Postmarketing Data Link Fezolinetant Primarily to Early Transaminase Elevations Rather Than Overt Liver Injury
FAERS postmarketing data suggest fezolinetant is associated with an early hepatic adverse event reporting signal, driven mainly by liver enzyme elevations rather than consistent severe clinical liver injury.
Exercise May Be a Disease-Modifying Strategy in Chronic Pancreatitis
A new multimodal study links regular physical activity to lower chronic pancreatitis risk and identifies muscle-derived extracellular vesicles as a plausible mechanism limiting pancreatic inflammation, fibrosis, and ferroptosis.
Glycemic Control and Diabetes Outcomes After Surgical Therapy for Diabetic Gastroparesis
Surgical therapy for diabetic gastroparesis was linked to better long-term HbA1c control, less insulin use, and fewer diabetes-related complications, though mortality was unchanged.
Urgent versus early ERCP in mild-to-moderate acute cholangitis: what the trial found
In mild-to-moderate acute cholangitis, ERCP within 24 hours did not improve mortality or organ-failure outcomes versus ERCP within 24–48 hours, and it was linked to more procedure-related adverse events.
Targeting Oncomucin-Driven Immunosuppression Improves KRAS G12D Inhibition in Pancreatic Cancer
Oncomucins such as MUC4 and MUC16 help pancreatic cancer evade immunity through EGFR/UNC5B signaling. Targeting these mucins may enhance KRAS G12D inhibitor efficacy and reduce tumor burden.
Adolescent MASLD Plus PCOS Signals a Higher-Risk Cardiometabolic Trajectory Into Adulthood
In the Raine Study, adolescents with both MASLD and PCOS had a substantially worse cardiometabolic profile by age 27 than peers with either condition alone, highlighting a high-risk subgroup that may warrant earlier metabolic surveillance.
Metabolic Dysfunction Did Not Worsen Short-Term Survival in Severe Alcohol-Associated Hepatitis in a Global Prospective Cohort
In a 32-center international cohort, cardiometabolic risk factors were common in alcohol-associated hepatitis but did not independently increase 180-day mortality after adjustment for liver disease severity and competing transplant risk.
PTEN Loss Drives MHC-I Evasion and Checkpoint Resistance in Microsatellite Stable Colorectal Cancer via NRF2-Dependent Autophagy
A Gut study links PTEN deficiency in MSS colorectal cancer to NRF2-driven autophagic loss of MHC-I, impaired CD8+ T-cell surveillance, and resistance to anti-PD-1 therapy, while identifying NRF2 inhibition as a potential sensitizing strateg
Duodenal Recombinant RORDEP1 Was Safe and Triggered Early Incretin-Insulin Responses in Healthy Men
In a randomized crossover trial, short-term duodenal r-RORDEP1 infusion was well tolerated and produced early changes in GLP-1, GIP, insulin, C-peptide, glucose, and a measure of insulin sensitivity in healthy men.
Intraperitoneal and Intravenous Paclitaxel Plus S-1 Improves Survival in Gastric Cancer With Peritoneal Metastasis: Phase 3 Trial
A phase 3 trial found that adding intraperitoneal paclitaxel to intravenous paclitaxel plus S-1 improved survival in gastric cancer with peritoneal metastasis without increasing severe toxicity.
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