Evaluating Dose Intensification Strategies for Ustekinumab in Crohn’s Disease: Insights from the REScUE Trial
Highlight
This prospective randomized trial investigated dose intensification with ustekinumab in Crohn’s disease patients experiencing secondary loss of response. Two regimens – intravenous reinduction plus either every 4-week or every 8-week subcutaneous maintenance dosing – were compared over 48 weeks. Steroid-free clinical remission rates were low and statistically similar between groups, with comparable safety profiles.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.