Unraveling the KLF9-NR4A1-p38 MAPK Axis: A Novel Mechanism Linking Intermittent Hypoxia to MASLD in Obstructive Sleep Apnea
Highlight
– KLF9 is significantly upregulated by intermittent hypoxia (IH) and plays a pivotal role in driving metabolic dysfunction-associated steatotic liver disease (MASLD).
– KLF9 suppresses transcription of the nuclear receptor NR4A1, inhibiting downstream activation of p38 MAPK signaling, which is crucial for maintaining hepatic metabolic balance.
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.