Gastroenterology
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Genetic Risk of Inflammatory Bowel Disease Linked to Disease Severity
A Danish nationwide study reveals higher genetic risk scores for IBD predict more severe disease courses, including increased surgery rates, stronger medication needs, and worse inflammatory markers in both Crohn’s and ulcerative colitis pa
Oral Glucose Absorption Enhanced in Early Metabolic Dysfunction-Associated Steatotic Liver Disease
New research reveals accelerated glucose absorption in early MASLD patients, independent of gastric emptying. This metabolic alteration may drive liver disease progression before hepatic insulin resistance develops.
Early MASLD Is Associated With Enhanced Oral Glucose Absorption Independent of Gastric Emptying
Stable-isotope OGTT data suggest that early MASLD is linked to higher oral glucose absorption, independent of gastric emptying, with preserved hepatic insulin suppression but impaired peripheral glucose clearance.
CD276 Identified as Key Driver of Chemoresistance in Advanced Pancreatic Cancer
Single-cell analysis reveals CD276/B7-H3 as a critical regulator of chemoresistance in pancreatic ductal adenocarcinoma, highlighting its dual role in promoting basal-like tumor states and immune evasion.
Fecal Microbiota Transplant Fails to Decolonize Multidrug-Resistant Organisms in GI Patients: A Randomized Trial Analysis
A randomized clinical trial found that FMT did not significantly decolonize MDROs or reduce AMR genes in GI disease patients, though it modulated gut microbiome composition.
Early Enteral Nutrition Reduces Postoperative Complications in High-Risk Pancreatoduodenectomy Patients
The NUTRIWHI trial demonstrates that early enteral nutrition via nasojejunal tube significantly reduces complication burden in nutritionally high-risk patients after pancreatoduodenectomy compared to oral nutrition alone.
Mucosal Impedance: A Novel Diagnostic Tool for Refining GERD Phenotyping and Surgical Decision-Making
Mucosal impedance (MI) offers a groundbreaking approach to assess esophageal mucosal integrity in GERD, complementing traditional diagnostics and enhancing surgical outcomes.
Combination Therapy with GLP-1 Receptor Agonists and SGLT-2 Inhibitors Reduces Liver and Cardiovascular Risks in MASLD and Type 2 Diabetes
A study reveals that combining GLP-1 receptor agonists with SGLT-2 inhibitors significantly lowers the risk of major adverse liver and cardiovascular outcomes in patients with MASLD and type 2 diabetes compared to monotherapy.
CD16+ γδ T Cells: A Novel Player in HBV Viral Control Through Antibody-Dependent Cytotoxicity
A study reveals CD16+ γδ T cells as key mediators of antibody-dependent cellular cytotoxicity in HBV infection, correlating with reduced viral replication and offering new therapeutic targets.
Clonal Lymphocyte Expansions and JAK-STAT Mutations Drive Refractory Celiac Disease
This study uncovers clonal lymphocyte expansions and JAK-STAT pathway mutations as key drivers of refractory celiac disease, suggesting a shared pathogenic continuum between RCD1 and RCD2 while cautioning against JAK inhibitor monotherapy d
A New Framework to Refine Hepatocellular Cancer Surveillance with Risk Stratification Models
The Translational Liver Cancer Consortium proposes a structured framework for developing and validating risk models to optimize HCC surveillance, addressing gaps in current clinical guidelines.
Protein Misfolding in the Gut: A Window into Future Neurodegeneration
GI biopsies reveal misfolded proteins years before neurological symptoms appear, offering a new biomarker for early neurodegenerative disease prediction and intervention.
Somatostatin in the Gut: No Diabetes-Specific Patterns Found
New study reveals uniform distribution of somatostatin and its receptors throughout the intestinal tract in both healthy individuals and type 2 diabetes patients, challenging previous assumptions about its role in diabetes pathophysiology.
Unraveling the Gut-Heart Connection: How Leaky Gut Fuels Atrial Fibrillation in Aging
Researchers identify JNK2 as a key mediator in gut-heart crosstalk, linking intestinal permeability to atrial fibrillation pathogenesis through inflammatory stress signals, offering new therapeutic targets.
腹腔鏡と開腹手術による小腸閉塞癒着剥離の長期転帰：LASSO無作為化臨床試験
小腸閉塞手術における腹腔鏡アプローチは短期回復が早いが、5年間の追跡調査では再発率、ヘルニア発生率、QOLにおいて開腹手術と同等の結果を示した。術式選択は患者個別の要因に基づくべきである。
OCE-205 Signals a Potential New Direction for Hepatorenal Syndrome-AKI, with Tolerability at the Center
In a phase 2 randomized trial, OCE-205 improved HRS-AKI in more patients than placebo and showed no excess ischemic or respiratory toxicity, but the study was underpowered after early termination.
A Blood-Based Extracellular Vesicle RNA Signature May Offer a New Way to Diagnose Chronic Pancreatitis
A five-RNA extracellular vesicle signature showed strong diagnostic performance for chronic pancreatitis and may also reflect acinar-to-ductal metaplasia and disease-related metabolic features.
Delayed Surgery in Bowel Obstruction: A Hidden Driver of Mortality and Recurrence in France
A nationwide French study reveals that surgical delay beyond 9 days triples early mortality risk compared to immediate surgery. While non-operative management carries higher long-term recurrence, timely laparoscopic intervention offers the
Perioperative Nivolumab Combined with Irreversible Electroporation Shows Antitumoral Effect in High-Risk BCLC A Hepatocellular Carcinoma: Results from the NIVOLEP Phase 2 Trial
The NIVOLEP phase 2 trial demonstrates that perioperative nivolumab (neoadjuvant and adjuvant) combined with irreversible electroporation achieves 70.6% one-year local recurrence-free survival in BCLC A HCC patients with high recurrence ris
Portal Tryptophan Depletion Drives Hyper-Reactive Neutrophils in Alcoholic Liver Disease: Insights from a Prospective TIPS Study
A prospective study reveals that decreased tryptophan levels in portal circulation induce neutrophil hyperactivation in alcoholic liver disease. In vitro supplementation with tryptophan ameliorated neutrophil activation, identifying the gut
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