Cardiology
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Quality of Life After Percutaneous Coronary Intervention or Medical Therapy for Chronic Total Coronary Occlusions: EUROCTO and DECISION-CTO Meta-Analysis
A pooled analysis of EUROCTO and DECISION-CTO trials found PCI significantly improved quality of life, angina frequency, and SAQ scores compared to medical therapy for patients with chronic total coronary occlusions, with no increased risk

Mobile Health Intervention Achieves 24% Better Blood Pressure Control in Stroke Survivors: PINGS Trial Results from Ghana
The PINGS trial demonstrates that a 12-month nurse-led mobile health intervention significantly improves blood pressure control among Ghanaian stroke survivors, with 67% achieving target BP versus 43% in usual care. This pragmatic approach

Efficacy of Blood Pressure-Lowering Pharmacotherapy in Isolated Diastolic Hypertension: A Systematic Synthesis of Evidence
This review synthesizes recent evidence, including a landmark 2026 meta-analysis, showing that blood pressure-lowering therapy provides similar cardiovascular benefits in patients with isolated diastolic hypertension compared to those with

Blood Eosinophil Count at COPD Exacerbation Predicts Long-Term Cardiovascular Risk: A Retrospective Cohort Study
A large retrospective cohort study of 143,517 patients reveals that non-eosinophilic acute exacerbations of COPD carry a significantly higher one-year risk of major adverse cardiovascular events compared with eosinophilic exacerbations, sug

Teleneurological Ward Rounds Outperform On-Site Consultations in Subacute Stroke Care: A Prospective Multicenter Study
A prospective multicenter study demonstrates that teleneurological ward rounds achieve 92% guideline adherence versus 54% for on-site consultations in subacute stroke care, with superiority across all quality domains and most pronounced ben

Genetic Risk Scores and Postpartum Hypertension: Integrating Polygenic Insight with Clinical Risk Stratification
This review explores how polygenic risk scores and clinical factors like BMI and pregnancy history predict incident hypertension 2 to 7 years post-delivery, highlighting the dominance of modifiable risk factors over genetic predisposition.

LBBP Matches BiVP in ECG Metrics but Excels at Cellular Level: Canine Study Redefines Cardiac Resynchronization Therapy
A canine study reveals left bundle branch pacing achieves equivalent QRS narrowing and ejection fraction improvement as biventricular pacing, yet demonstrates superior recovery of cardiac mechanics, calcium handling, and energy metabolism a

Apolipoprotein C-III Inhibition and the Atherosclerosis Paradox: Lessons from the Essence-TIMI 73b Olezarsen Study
The Essence-TIMI 73b trial reveals that despite a 64% reduction in triglycerides and a 72% drop in remnant cholesterol via olezarsen, non-calcified coronary plaque volume remained unchanged over 12 months.

Timing of Atrial Fibrillation Diagnosis Does Not Alter Early Anticoagulation Benefits in Stroke Patients: Insights from the OPTIMAS Trial
Subgroup analysis of the OPTIMAS trial reveals that neither the timing of atrial fibrillation diagnosis nor AF subtype modifies the treatment effect of early versus delayed direct oral anticoagulant initiation in acute ischemic stroke. Pers

Timing Extubation After Thrombectomy: Evidence from the EDESTROKE Trial and Advanced Post-Reperfusion Management
The EDESTROKE trial finds no significant difference in 90-day functional outcomes between early (

Decoding the Heart Failure Peptidome: A Cross-Sectional Study Uncovers Novel Biomarkers and Patient Clusters
A groundbreaking mass spectrometry study analyzing 486 heart failure patients and 98 controls identified over 21,000 unique peptides, revealing 1,924 differentially expressed peptides. The research highlights angiotensin-related peptides, n

Only 1 in 5 Veterans with Heart Failure Achieve Recommended Quadruple Therapy Within 3 Years—What This Means for Clinical Practice
A large retrospective study of 52,850 veterans reveals that just 21.2% achieve guideline-directed quadruple therapy for HFrEF, with a median time of 197 days. Socioeconomic barriers, including prescription copays, emerge as critical modifia

Pulsed Field Ablation Matches Radiofrequency in Efficacy but Shows Superior Safety Profile for Paroxysmal Atrial Fibrillation: BEAT PAROX-AF Trial
The BEAT PAROX-AF trial demonstrates equivalent single-procedure success rates between pulsed field ablation (77.2%) and radiofrequency ablation (77.6%) for paroxysmal atrial fibrillation, while showing a numerically lower safety event rate

Redefining the Renin-Aldosterone Axis: From Categorical Diagnosis to a Continuous Spectrum of Cardiorenal Risk
This article synthesizes evidence from a 2026 Danish nationwide cohort and supporting literature, illustrating that renin-independent aldosterone production represents a continuous risk gradient for kidney failure and MACE, even below tradi

Adaptive AI Transforms Cardiovascular Event Adjudication: New Algorithm Achieves Near-Human Accuracy Across Multiple Endpoints
Researchers developed and validated ADAPT-CEC, an artificial intelligence algorithm that can adjudicate cardiovascular events across different trial definitions. A hybrid approach combining AI with selective human review achieved 95.6% accu

Volume Matters: New Study Defines Minimum Annual Caseload for Safer Fenestrated and Branched Aortic Repair
Researchers identify critical hospital and surgeon volume thresholds for fenestrated/branched endovascular aortic repair (F/BEVAR). Patients treated at low-volume centers face up to 51% higher 30-day mortality, with inflection points at 9 h

Precision Phenotyping in Cardiometabolic Medicine: Genetic Susceptibility of Diabetes Subtypes and Coronary Artery Disease Risk
This review synthesizes evidence on the genetic architecture of adult-onset diabetes subtypes, highlighting that Moderate Obesity-related Diabetes (MOD) is uniquely and causally linked to coronary artery disease risk through polygenic and M

STEMI and NSTEMI Are Not the Same in Type 1 Diabetes: Finnish Cohort Reveals Distinct Risk Patterns
In Finnish adults with type 1 diabetes, STEMI and NSTEMI showed distinct incidence trends and risk profiles. NSTEMI was more common overall and linked to dyslipidemia and advanced microvascular disease, whereas impaired eGFR tracked more wi

Long-Term Durability and Clinical Stability of Acoramidis in Transthyretin Amyloid Cardiomyopathy: A 54-Month Synthesis
This review synthesizes the 54-month results of the ATTRibute-CM open-label extension, demonstrating that early and continuous acoramidis treatment provides sustained reductions in mortality and cardiovascular hospitalizations while maintai

Cardiologist Evaluation After Postoperative Myocardial Injury Was Linked to Better 1-Year Outcomes
Post-operative cardiologist evaluation after peri-operative myocardial injury was associated with fewer major cardiac events and lower 1-year mortality in high-risk non-cardiac surgery patients.
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