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Rigosertib demonstrates significant reversal of hypertrophic cardiomyopathy and other syndromic features in Noonan syndrome models, highlighting its potential as a targeted therapy for RASopathy-associated cardiac and developmental abnormal
Social vulnerability significantly elevates mortality and complications after major cardiac surgery, and treatment at high-volume centers does not mitigate these disparities, highlighting the need for systemic interventions beyond hospital
This study reveals distinct thromboembolic, bleeding, and mortality risks based on antiseizure medication selection in epilepsy patients receiving direct oral anticoagulants, highlighting the critical role of ASM choice on patient safety an
Emerging evidence identifies circulating imidazole propionate, a gut microbiota-derived metabolite, as an independent predictor of major adverse cardiovascular events in patients with coronary artery disease, offering novel insights into pe
This study reveals how HIF2 activation drives coronary artery remodeling, inflammation, and thrombosis in a mouse model mirroring severe Kawasaki disease, uncovering new therapeutic targets for coronary complications.
This observational study shows PCSK9 inhibitor monoclonal antibodies significantly reduce ischaemic events and mortality over five years in patients with ASCVD but no prior ischemic events, highlighting their preventive potential in routine
This nationwide Dutch cohort study reveals sex- and age-specific differences in mortality, long-term survival, and postdischarge care after ruptured abdominal aortic aneurysm repair, emphasizing the need for tailored management in women.
The CLEAN trial shows intravenous nicorandil adjunctive to primary PCI does not significantly improve 12-month clinical outcomes in STEMI. Evidence suggests microvascular benefits but no consistent long-term mortality or infarct size reduct
Levothyroxine treatment in older adults with subclinical hypothyroidism shows limited impact on cardiometabolic biomarkers overall but may benefit those with higher TSH levels, highlighting nuanced treatment implications and the need for ta
The RELIEVE-HF trial reveals distinct predictors of outcomes after interatrial shunt implantation in HFrEF and HFpEF, enabling personalized risk modeling to identify patients likely to benefit from this therapy.
Surgical unroofing significantly improves long-term symptoms and quality of life in patients with symptomatic myocardial bridge and non-obstructive coronary arteries refractory to medical therapy.
This review integrates recent randomized trial data with observational studies to clarify cannabis inhalation’s acute impact on cardiac ectopy, physical activity, sleep, and glucose, highlighting complex arrhythmia associations and cl
This study reveals a high heart failure risk within 5 years of diabetes diagnosis, highlighting insulin resistance and reduced kidney function as independent predictors beyond conventional risk factors.
Serial nuclear magnetic resonance metabolic profiling reveals distinct lipid and inflammatory markers predictive of adverse outcomes in chronic heart failure, supporting its role in improving risk stratification.
This review synthesizes evidence linking NOAC use to slower cognitive decline and improved clinical outcomes in patients with atrial fibrillation and Alzheimer’s disease, highlighting advantages over warfarin and non-use.
This article explores a novel, biologically informed framework for monitoring transthyretin amyloid cardiomyopathy progression and treatment, emphasizing mechanism-specific strategies aimed at personalized care.
This multicenter study reveals improved outcomes in fetal cardiomyopathy, highlights genetic underpinnings in one-third of cases, and identifies fetal hydrops and extracardiac anomalies as key prenatal risk factors for mortality.
Vutrisiran, an RNA interference therapeutic, significantly improves cardiac function, reduces amyloid burden, and attenuates disease progression in transthyretin amyloid cardiomyopathy as revealed by multiparametric cardiovascular MRI and c
This analysis reveals that waist circumference and waist-to-hip ratio improve cardiovascular risk classification beyond BMI, identifying individuals with hidden risk and refining prognostic assessments across multiple cardiovascular outcome
This study identifies pre-transplant left atrial volume index as a potential predictor for overall one-year morbidity following kidney transplantation, highlighting its clinical relevance beyond traditional cardiac risk markers.
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