Spontaneous Preterm Birth as a Sentinel for Cardiovascular Mortality: Insights from a National Registry Study

MedXY Editorial Team•Jun 4, 2026•Cardiology

Women with a history of spontaneous preterm birth (sPTB) exhibit a 38% increased risk of cardiovascular mortality (CVM) compared to those with term births.
The risk for CVM is gestation-dependent, peaking at a three-fold increase (aHR 3.19) for women with early spontaneous preterm birth occurring before 32 weeks.
While the risk is lower than that associated with hypertensive disorders of pregnancy (HDP) or fetal growth restriction (FGR), sPTB remains an independent and significant predictor of long-term cardiovascular health.
Postpartum cardiovascular screening and risk stratification are increasingly recommended for all women with a history of preterm delivery, regardless of the subtype.

MedXY registered readers

Sign in free to continue reading

Create or use your MedXY account to unlock the complete article.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

Women with a history of spontaneous preterm birth (sPTB) exhibit a 38% increased risk of cardiovascular mortality (CVM) compared to those with term births.
The risk for CVM is gestation-dependent, peaking at a three-fold increase (aHR 3.19) for women with early spontaneous preterm birth occurring before 32 weeks.
While the risk is lower than that associated with hypertensive disorders of pregnancy (HDP) or fetal growth restriction (FGR), sPTB remains an independent and significant predictor of long-term cardiovascular health.
Postpartum cardiovascular screening and risk stratification are increasingly recommended for all women with a history of preterm delivery, regardless of the subtype.