Implantable Monitor–Guided, Nurse-Led Diuretic Escalation Was Safe but Did Not Improve Outcomes in ALLEVIATE-HF

Highlights

ALLEVIATE-HF tested whether an insertable cardiac monitor (ICM) with investigational heart failure risk detection, coupled to centrally coordinated nurse-facilitated protocolized diuretic adjustment, could improve outcomes in patients with heart failure.

The strategy met its prespecified safety objective. Intervention-related serious adverse events were rare at 0.32% (95% CI: 0.10%-0.99%), well below the prespecified safety threshold of 5%.