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Highlight This unprecedented large-scale multinational study developed a semisupervised contrastive machine learning framework that generates a global
Registry-based randomised controlled trials (RRCTs) offer promising efficiencies and external validity over traditional RCTs, yet lack consistent definitions and registration standards. A proposed taxonomy and adherence to CONSORT-ROUTINE a
This review synthesizes contemporary evidence on the survival impact of adding defibrillators to CRT in nonischemic cardiomyopathy, highlighting heterogeneous results including the DECIDE-CRT study and underscoring the need for personalized
A large Chinese cohort study reveals a U-shaped association between left ventricular end-diastolic diameter and mortality in heart failure, highlighting both small and large ventricular sizes as independent risk factors.
This propensity-matched study shows that in patients undergoing tricuspid TEER for severe TR, untreated moderate MR is linked to worse survival, while combined mitral and tricuspid TEER improves mortality and functional outcomes, highlighti
In low-risk severe aortic stenosis patients, both TAVR and SAVR provide sustained health status improvements over seven years, with TAVR offering faster early recovery but similar long-term health outcomes.
This study reveals that left ventricular hypertrabeculation, common in dilated cardiomyopathy, does not increase embolic risk or adverse outcomes, challenging previous concerns and guiding clinical management.
A race-free adaptation of the MESA risk score estimates 10-year coronary heart disease risk with comparable accuracy to the original, challenging the necessity of including race/ethnicity in cardiovascular risk prediction.
A multicenter study reveals that preserving donor hearts at 10°C results in better early graft function and one-year survival than traditional 4-8°C storage, suggesting a new standard for heart transplant preservation.
The 2026 ESC clinical consensus outlines creation of multidisciplinary Women’s Heart Centres to close gaps in diagnosis, management, and research for women’s cardiovascular disease across the life course.
This substudy of the CHIP-BCIS3 trial assessed the effects of elective left ventricular unloading via microaxial flow pump during complex PCI, finding reduced inotrope use but no significant hemodynamic or myocardial stunning benefits.
This study evaluates the incidence, severity, and predictors of extracranial bleeding in atrial fibrillation patients on oral anticoagulants, highlighting its substantial burden beyond major bleeds and informing bleeding risk management.
In patients with OSA and elevated blood pressure, comorbid insomnia is linked to a significantly greater blood pressure reduction following short-term CPAP therapy, highlighting the clinical importance of addressing both sleep disorders.
This study reveals that higher parity is associated with subtle reductions in myocardial strain during pregnancy, suggesting cumulative cardiovascular effects despite normal ejection fraction.
The VasCog-2-WSO criteria effectively detect MRI-defined vascular cognitive impairment in asymptomatic adults, correlating with increased cardiovascular risk and mortality, highlighting their utility for early diagnosis and community risk s
This 25-year prospective study evaluates the prognostic value of quantified mitral regurgitation (MR) severity and shows that early surgical intervention in upper-moderate MR improves long-term survival in asymptomatic patients.
In adults with repaired Tetralogy of Fallot undergoing pulmonary valve replacement, an electrophysiology-guided ablation strategy significantly reduces ventricular tachycardia inducibility and long-term arrhythmic risk compared to empiric a
Nongated coronary artery calcium (CAC) scoring from routine chest CT scans can predict cardiovascular events as reliably as standard gated CAC scans, offering widespread opportunities for risk stratification and preventive care.
This study demonstrates that dapagliflozin does not impair LDL catabolism but favorably shifts VLDL1 and VLDL2 catabolism toward normal physiology in type 2 diabetes, potentially contributing to reduced atherosclerosis risk.
Common bedside tests for peripheral arterial disease in diabetic patients show poor sensitivity, challenging their clinical reliability compared to advanced imaging modalities.
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