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Echocardiography-derived right ventricular phenotypes improve prognostic accuracy beyond standard risk tools in pulmonary arterial hypertension patients at first follow-up, refining survival predictions and guiding management strategies.
This cluster-randomized trial in rural China demonstrates that a coordinated community- and family-based intervention effectively lowers systolic blood pressure at the population level, highlighting the importance of sustained community eng
Combined intrahepatic and periduodenal lymphatic embolization significantly improves protein balance and remission duration in congenital heart disease patients with protein-losing enteropathy compared to intrahepatic embolization alone, of
This prospective registry reveals a significantly increased risk of stroke or transient ischemic attack within 30 days after pulsed field ablation compared to radiofrequency ablation for atrial fibrillation, highlighting important safety co
This study reveals that pulmonary artery stiffness and right ventricular function parameters independently predict mortality better than pulmonary vascular resistance in mild pulmonary hypertension, supporting their role in early disease ri
A Swedish cohort study reveals increased adoption and high adherence to quadruple pharmacotherapy in HFrEF, associating treatment persistence with better clinical outcomes and highlighting areas for improved dosing and continuation.
This study demonstrates the lack of mechanistic specificity of clinical capillary leak indices in heart failure patients, underscoring their limitations as universal markers of endothelial permeability beyond acute inflammatory states.
Cascade genetic screening in hereditary transthyretin amyloidosis (ATTRv) enables earlier diagnosis and intervention, improving survival and highlighting the need for variant-specific surveillance strategies.
This study maps apo AI glycation sites in diabetes, linking them to HDL dysfunction and diabetic atherosclerosis via RAGE-associated signaling, and demonstrates that glycation-resistant apo AI preserves HDL function and lessens atherosclero
Post-MI adherence to diverse healthy dietary patterns is consistently linked to reduced mortality and cardiovascular events, underscoring the importance of diet quality in secondary prevention among MI survivors.
Carvedilol demonstrates superior effectiveness over nadolol and propranolol in reducing portal hypertension and preventing cirrhosis decompensation events, with emerging evidence supporting its preferential use in both compensated and decom
This study integrates vascular mechanics, advanced imaging, and myocardial transcriptomics to elucidate the mechanisms of right ventricular failure in pulmonary hypertension secondary to heart failure with preserved ejection fraction, uncov
This study reveals that intermittent hypoxia activates GLI1 transcription factor in cardiac fibroblasts, driving fibrosis via PKM2-mediated glycolysis, and highlights GLI1 as a promising therapeutic target in OSA-associated cardiac dysfunct
A clear, global update standardizing heart failure terminology, phenotypes, causes, and trajectories to improve prevention, diagnosis, treatment, and global surveillance.
Long-term data from lung cancer screening reveal centrilobular emphysema progression strongly associates with coronary artery calcification worsening, highlighting systemic vascular implications of this emphysema subtype.
This population-wide study demonstrates that parathyroidectomy in primary hyperparathyroidism reduces major adverse cardiovascular events risk, particularly in patients with higher serum calcium levels.
Early weight loss after impaired glucose tolerance diagnosis is linked to markedly reduced long-term risk of cardiovascular events and death, underscoring the importance of early lifestyle interventions in prediabetes management.
This study reveals that risk factor associations for subsequent coronary heart disease (CHD) events are systematically attenuated due to index event bias, challenging their clinical interpretation in secondary prevention and emphasizing the
This meta-analysis of 17 Phase 3 RCTs reveals that BTK inhibitors, primarily ibrutinib, increase the risk of non-fatal ischemic cardiovascular events in patients with B-cell malignancies, highlighting important safety considerations.
Clonal hematopoiesis (CHIP) significantly associates with increased silent brain lesions and progressive cognitive decline in atrial fibrillation patients, highlighting a novel neurovascular risk factor with implications for patient managem
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