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Vagal Nerve Stimulation in HFrEF Was Safe but Did Not Improve the Primary Composite Outcome in the ANTHEM-HFrEF Trial
In ANTHEM-HFrEF, vagal nerve stimulation in symptomatic HFrEF was feasible and safe, but the underpowered trial did not meet its primary efficacy endpoint after premature sponsor-driven termination.
SREBP1 Activation of NHE3 Weakens Heart Contraction and Worsens Heart Failure
Researchers found that SREBP1 directly activates NHE3 in failing hearts, causing sodium and calcium overload, weaker cardiac contraction, and worse heart failure. The findings reveal a new mechanism in HFrEF and suggest a potential therapeu
Bireociclib Plus Fulvestrant in Advanced Breast Cancer After Endocrine Progression: The BRIGHT-2 Phase 3 Randomized Clinical Trial and Comparative Synthesis
This review synthesizes the BRIGHT-2 trial findings and meta-analytical data, confirming that bireociclib plus fulvestrant significantly improves progression-free survival in HR+/HER2- advanced breast cancer.
Health Plan Disenrollment and Mortality After Starting Medications for Opioid Use Disorder
A large cohort study found that health plan disenrollment after starting buprenorphine or naltrexone for opioid use disorder was linked to higher all-cause and overdose mortality, highlighting the importance of continuous coverage and treat
Out-of-Bed Armchair Positioning Improves Oxygenation in Spontaneously Breathing ICU Patients
A randomized ICU trial found that sitting spontaneously breathing patients in an armchair for 3 hours improved oxygenation more than staying semi-recumbent in bed, with no serious adverse events.
ICU Readmission Raises 60-Day Mortality Substantially Regardless of Frailty, but Frail Patients Carry the Highest Absolute Risk
In a binational registry study of 615,719 ICU admissions, ICU readmission was linked to a similar absolute increase in 60-day mortality in frail and nonfrail patients, although frail readmitted patients had the highest overall mortality.
Intravenous Magnesium Sulfate for Acute Nontraumatic Headache in the Emergency Department
Intravenous magnesium sulfate added to paracetamol increased early headache-treatment success in the emergency department, but the pain relief was modest and below usual clinical importance thresholds. It also reduced rescue analgesia needs
Do Digital Specialist Consults Really Keep Patients Out of the Hospital?
A new Dutch study suggests e-consults may not dramatically cut hospital referrals overall, but they still offer important benefits when used in the right patients, specialties, and workflows.
Rapid Respiratory Point-of-Care Testing and Antibiotic Use in Primary Care: A Randomized Clinical Trial
A randomized trial found that rapid respiratory point-of-care testing did not reduce same-day antibiotic prescribing in primary care, though it was safe and may help when a virus is detected.
ACP Calls for Stronger Oversight of Medicare Advantage to Protect Patients, Payment Accuracy, and Quality
The American College of Physicians urges major reforms to Medicare Advantage, including more accurate payment, simpler quality measures, tighter oversight of marketing and prior authorization, and stronger transparency to better protect ben
Frontline Allogeneic Transplantation Outperforms Pretransplant IPSS-M Downstaging in Myelodysplastic Neoplasms
In adults with myelodysplastic neoplasms undergoing allogeneic transplantation, pretransplant cytoreduction modestly improved IPSS-M in some patients but did not improve post-transplant survival and was associated with higher non-relapse mo
Choosing a Stem Cell Donor: Why Age Matters More in Some Transplants Than Others
A major 2026 study suggests donor age affects survival differently in haploidentical and matched unrelated stem cell transplants, offering a more practical framework for choosing the best donor.
Effectiveness of Automatically-Adjusted vs Manually-Adjusted Noninvasive Ventilation in Obesity Hypoventilation Syndrome: A Randomized Clinical Trial
In ambulatory patients with obesity hypoventilation syndrome, automatically-adjusted noninvasive ventilation was as effective as manually adjusted NIV over 12 months and more cost-effective, offering a simpler path to treatment.
Anesthesia-Related Neurologic Risk in Patients of Venezuelan Descent: Implications for Ophthalmology
A rare, severe neurologic complication has been linked to general anesthesia in patients of maternal Venezuelan descent. Ophthalmologists should screen for ancestry and family history, involve anesthesiology early, and consider genetic eval
Small Copy Number-Neutral Intrachromosomal Translocation of PAX6 and Aniridia
Optical genome mapping and long-read sequencing uncovered a tiny balanced rearrangement that separated PAX6 from its control region, explaining classic aniridia after prior testing was negative.
Intraoperative Intravitreal Bevacizumab Extended Trabeculectomy Survival to 3 Years in a Randomized Trial
A double-blind randomized trial found that a single intraoperative intravitreal bevacizumab injection improved 3-year trabeculectomy survival and reduced postoperative medication needs versus placebo.
Body Mass Index and Nutritional Status With Immunotherapy Response in Head and Neck Cancer
In advanced head and neck squamous cell carcinoma, pretreatment weight loss and low prognostic nutritional index were linked to shorter progression-free survival after immunotherapy, while baseline BMI was not predictive.
Earlier Cricopharyngeal Intervention May Improve Oral Intake in Absent UES Opening After Neurological Injury
A small retrospective series suggests that cricopharyngeus-targeted procedures can improve upper esophageal sphincter opening and oral intake after neurological injury, but aspiration risk often persists and ongoing swallowing therapy remai
Unequal Paths to Care: How Region, Rurality, and Deprivation Shape Transport to Verified Trauma Centers Among the Critically Injured
A large U.S. study found major geographic and socioeconomic differences in how critically injured patients are transported to verified trauma centers, with outcomes varying by region, rurality, and neighborhood deprivation.
Higher-Fidelity Enhanced Recovery Shortened Stay and Reduced Complications in Children Undergoing GI Surgery, Even Though the Overall Trial Was Neutral
In a stepped-wedge trial across 18 US centers, a pediatric GI surgery enhanced recovery protocol did not improve length of stay overall, but patients receiving at least 13 protocol elements had shorter stays, fewer complications, faster die
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