Synergistic Impact of Clonal Hematopoiesis and Genetic Predisposition on Age-Related Macular Degeneration Risk: Insights from a Large UK Biobank Cohort
Clonal hematopoiesis of indeterminate potential (CHIP) independently elevates the risk of incident age-related macular degeneration (AMD) by 14%.
Mutations in DNMT3A, spliceosome, and DNA damage repair genes notably contribute to heightened AMD risk.
A high polygenic risk score (PRS) for AMD synergistically interacts with CHIP, leading to a more than threefold increased risk of AMD.
The interplay between CHIP and genetic predisposition is particularly pronounced in older adults, suggesting age-related amplification of these risk factors.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
