Nicotinamide Supplementation and Primary Open-Angle Glaucoma in Patients With Ocular Hypertension: Evidence, Mechanisms, and Clinical Implications
Highlights
- Real-world cohort data reveal systemic nicotinamide use is associated with a 66% reduction in POAG conversion risk in patients with ocular hypertension.
- Randomized clinical trials demonstrate nicotinamide improves inner retinal function and visual field measures in established glaucoma.
- Niacinamide supplementation enhances quality of life metrics and modestly lowers intraocular pressure, supporting multifaceted benefits.
- Ongoing trials combining nicotinamide with pyruvate aim to elucidate metabolic neuroprotection mechanisms and optimize glaucoma management strategies.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.