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Associations of the Composite Pulmonary Embolism Shock Score in the Emergency Department With Short-Term Clinical Outcomes
A multicenter emergency department study found that CPES performed similarly to sPESI and ESC for short-term PE outcomes, but it better predicted the need for advanced intervention.
Implementation of a Hospital-Based Screening and Treatment Program for Unhealthy Alcohol Use
A hospital-based screening and treatment program for unhealthy alcohol use was feasible in a diverse safety-net population and was linked to short-term reductions in alcohol risk scores, especially among patients who received follow-up and
Provision of Primary Care Under Reduced Visit Time Pressures
Reduced visit time pressure in primary care was linked to slightly more diagnoses, prescriptions, and diagnostic testing, especially for patients with multiple chronic conditions. The study highlights how appointment scheduling can influenc
Telemedicine After the Pandemic: Who Benefits, What Changed, and What Comes Next
Telemedicine is no longer an emergency workaround. New policy guidance shows how virtual care can improve access, but only if payment, safety, equity, and prescribing rules evolve carefully.
CBFB::MYH11 MRD After the Second Chemotherapy Cycle: A Guide to Allogeneic Transplantation in Favorable-Risk AML
Post-cycle 2 CBFB::MYH11 MRD best predicted outcomes in favorable-risk AML. Patients with levels ≥1% had higher relapse risk, and those receiving allo-HCT in CR1 had better 3-year disease-free survival than chemotherapy consolidation.
Comprehensive Mutational Profiling and Clinical Outcomes in Adult AML with NUP98 Rearrangement
Adult AML with NUP98 rearrangements is a high-risk subtype marked by frequent FLT3-ITD and WT1 mutations, poor survival, and potential benefit from FLT3 inhibitors and stem cell transplant.
Evolution of Tumor Subclones and T-Cell Dynamics Underlie Variable Ibrutinib Responses in Waldenström Macroglobulinemia
Single-cell profiling of WM during ibrutinib therapy revealed three tumor evolution patterns, a predictive WIP score, and T-cell dysfunction linked to resistance and disease progression.
Dual versus monotherapy pretreatment before balloon pulmonary angioplasty in CTEPH: effects on complications and outcomes
In CTEPH patients undergoing balloon pulmonary angioplasty, dual pulmonary hypertension-targeted pretreatment was linked to fewer thoracic complications and better 6-month clinical improvement than monotherapy.
Lower Airway Dysbiosis in NTM-Positive Bronchiectasis Is Linked to NET-Dominant Severe Phenotypes
In NTM-positive bronchiectasis, lower airway dysbiosis involving Mycobacterium and oral bacteria is linked to higher NET levels and more severe disease phenotypes, suggesting that the broader airway microbiome may shape inflammation and out
Delayed Glaucoma Follow-Up Was Usually Not Linked to Visual Field Progression, but Longer Gaps May Matter in More Advanced Disease
In a large retrospective glaucoma cohort, delayed follow-up was common yet was not generally associated with visual field worsening, although longer delays appeared more consequential in eyes with worse baseline visual field loss.
Optimizing Geographic Atrophy Clinical Trial Design: The Role of Run-In Phases, Single-Arm Architectures, and Functional Endpoints
This review synthesizes evidence on improving geographic atrophy trial efficiency through innovative run-in phases, single-arm designs, and superior functional biomarkers like microperimetry to reduce required sample sizes.
GLP-1 Weight-Loss and Diabetes Drugs: What Eye Specialists Say About NAION Risk
A new consensus statement advises cautious, shared decision-making about GLP-1 receptor agonists and NAION risk, noting that current evidence is observational, conflicting, and suggests any absolute risk increase is small.
Identifying High-Risk Children Safe for Same-Day Discharge After Tonsillectomy
Children with obesity and severe OSA usually stay overnight after tonsillectomy, but this study found most had no major complications. Oxygen nadir and AHI may help identify very low-risk patients who could be considered for same-day discha
Survival Outcomes After Neoadjuvant Chemotherapy in Node-Positive Hormone Receptor-Positive Breast Cancer”,
A national database study found that neoadjuvant chemotherapy was linked to worse overall survival than upfront surgery in node-positive hormone receptor-positive, HER2-negative breast cancer, except in patients who achieved nodal complete
Should Some Colon Cancers Be Treated Before Surgery? What a New Trial Means for Patients
A major randomized trial found that chemotherapy before surgery did not improve 3-year disease-free survival in locally advanced colon cancer, but it still revealed important clues for more personalized treatment.
Clipped Axillary Node Pathology May Support Axillary Surgery De-escalation After Neoadjuvant Therapy in Occult Breast Cancer
In occult breast cancer, clipped-node pathology after neoadjuvant therapy tracked residual axillary disease with high specificity, supporting limited axillary surgery in selected patients, especially those with cN1–cN2 disease.
Adding HE4 to the IOTA ADNEX Model for Differentiating Adnexal Masses: A Danish Prospective Multicenter Study
A Danish multicenter study found that adding HE4 to the IOTA ADNEX model offered only limited, threshold-dependent benefit for assessing adnexal masses, with no meaningful improvement in non-tertiary centers.
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