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Prone Positioning for Severe Hypoxemia Rose Sharply During COVID-19 but Was Not Sustained Across North American ICUs
In 37 North American hospitals, proning of eligible mechanically ventilated patients increased markedly during COVID-19, then fell post-pandemic, with substantial interhospital variation throughout.
An Emergency Department Nudge-Based Strategy to Screen and Treat Patients With Alcohol Misuse
A multicomponent emergency department workflow using screening, electronic prompts, and discharge decision support significantly increased naltrexone prescribing for patients with alcohol-related diagnoses.
Large-Scale Meta-Analysis Finds Higher Influenza and Shingles Risk with JAK-STAT Inhibitors
A large meta-analysis found JAK-STAT inhibitors slightly increased influenza, bronchitis, and herpes zoster risk, especially in atopic dermatitis, while serious and opportunistic infections were not significantly increased.
Hospital-Acquired DRESS and Clinical Severity Strongly Predict ICU Admission in a 39-Centre Paris Cohort
In this multicentre cohort of 207 hospitalized adults with DRESS, 17% required ICU care. Hospital-acquired DRESS and greater clinical severity independently predicted ICU admission, while ICU mortality reached 20%.
Frequent Pre-Admission Ambulatory Visits May Flag Harmful Diagnostic Error Risk in High-Risk General Medicine Inpatients
In a retrospective cohort of high-risk medical inpatients, frequent ambulatory care use before admission emerged as a predictor of harmful diagnostic error, highlighting a potentially actionable EHR-based signal for hospital diagnostic safe
COPD Cuts Life Expectancy in a Severity-Dependent Manner, With Losses Comparable to or Greater Than Diabetes and Smoking
A large pooled US cohort study found that COPD substantially reduces life expectancy, even among never-smokers, with years of life lost increasing progressively from GOLD stage 1 through stage 4.
Elevated Von Willebrand Factor and Factor VIII Show Promise as Biomarkers for Diagnosis and Monitoring of Chronic Graft-Versus-Host Disease
In a prospective cohort, VWF and FVIII were significantly elevated in chronic graft-versus-host disease, tracked with disease activity, and showed moderate diagnostic performance for early cGvHD.
Activity of PROTAC MDM2 Degrader in Primary Leukemia Cells and PDX Models
MD-265, a PROTAC MDM2 degrader, showed strong anti-leukemia activity in primary AML cells and mouse PDX models, outperformed a conventional MDM2 inhibitor, and spared normal stem cells relatively well.
Self-Reinforcing IL-1β Signaling Accelerates TCF3::HLF-Positive B-ALL Development and Relapse
Researchers found that IL-1β signaling drives growth, relapse, and bone damage in TCF3::HLF-positive B-ALL, suggesting IL-1β blockade may offer a new treatment strategy.
Where a Lung Transplant Candidate Is Listed Still Shapes Access to Donor Lungs Under U.S. Continuous Distribution
A national SRTR analysis shows that transplant center geography still strongly influences effective donor access after CAS implementation, and the 2026 proximity-weighted amendment is likely to widen disparities, especially for biologically
Motivational Interviewing and Air Cleaners for Smokers with COPD (MOVE): A Randomized, Double-Blind, Placebo-Controlled Trial
Portable HEPA air cleaners plus motivational interviewing improved symptoms and quality of life in smokers with COPD by reducing indoor particulate matter, though lung function and exacerbations did not significantly change.
Predictors of 1-Year Visual Outcome in Central-Involving Submacular Hemorrhage Secondary to Neovascular AMD
This study found that younger age, better baseline vision, smaller hemorrhage size, and thicker subfoveal choroid predicted better 1-year visual outcomes after fovea-involving submacular hemorrhage from nAMD or PCV.
Nonexudative Macular Neovascularization in Age-Related Macular Degeneration
In patients with unilateral exudative AMD, double-layer sign on OCT was common, but OCT angiography showed nonexudative macular neovascularization in only about 40% of DLS-positive fellow eyes.
Genomic Risk Profiling May Help Predict Which Patients With Fuchs Endothelial Corneal Dystrophy Progress to Keratoplasty
A 2026 Ophthalmology study suggests that combining CTG18.1 expansion testing with a FECD-specific polygenic risk score can improve prediction of keratoplasty risk across independent cohorts.
Volumetric Thresholds After Glossectomy May Predict Feeding Tube Dependence and Poor Speech
A retrospective cohort study suggests that preoperative tumor burden, extent of tongue resection, and degree of volume restoration are strongly associated with swallowing and speech outcomes after glossectomy.
Activity and Physiological Stress Within 90 Days After Minimally Invasive and Open Pancreatoduodenectomy
Wearable activity tracking in the DIPLOMA-2 trial found that minimally invasive pancreatoduodenectomy led to more activity for about 5 weeks and less physiologic stress up to 90 days versus open surgery.
Most Patients With Uncertain Response After Neoadjuvant Chemoradiotherapy for Esophageal Cancer Still Harbor Residual Disease
In the SANO cohort, 85% of patients with uncertain post-chemoradiotherapy response had residual tumor at esophagectomy, supporting surgery for most, while highlighting a notable complete response subgroup among squamous cell carcinoma with
Molecular and Spatial Differences in the Tumor Microenvironment of High-Grade Serous Ovarian Cancer With Short vs Long-Term Survival
This study found that advanced high-grade serous ovarian cancers from short-term survivors had more fibroblasts and stromal invasion signals, while tumors from long-term survivors showed stronger immune pathways, suggesting the tumor microe
Proteinuria in Preeclampsia and Long-Term Risk of Maternal Kidney and Cardiovascular Disease
Higher proteinuria in preeclampsia was linked to greater long-term risk of maternal hypertension and chronic kidney disease, with overall increased risk of cardiovascular disease as well.
Does the order of ablation of vein-to-vein placental connections during fetoscopic laser photocoagulation affect outcomes in twin-twin transfusion syndrome?
In TTTS, a post hoc analysis found that treating vein-to-vein placental connections at the end of fetoscopic laser surgery was linked to worse donor and recipient survival than earlier treatment.
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