Psychiatry
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Tailored Weight Loss Interventions in Serious Mental Illness: A Comprehensive Review of Evidence and Clinical Implications
This review synthesizes evidence on tailored weight loss programs for adults with serious mental illness, highlighting recent advances, effectiveness, mechanistic insights, and future directions.
Tailored Weight Loss Interventions for Veterans with Serious Mental Illness: Efficacy and Implementation Insights from Recent RCT Evidence
This review synthesizes evidence from a 2025 randomized clinical trial evaluating a tailored weight loss program, CoachToFit, for veterans with serious mental illness, highlighting its potential to improve weight outcomes via remote support
Mapping the Neuro-Immune Divide: Distinct Brain-Blood Signatures Distinguish Early Depression from Psychosis
A large-scale multicenter study identifies unique multivariate patterns of peripheral inflammation and brain structure that differentiate early-stage depression and psychosis, highlighting the influence of childhood trauma and cognitive per
First-Trimester Z-Drug Exposure Does Not Increase Overall Risk of Congenital Malformations
A large-scale US cohort study of over 4.2 million pregnancies found no significant association between first-trimester Z-drug exposure—primarily zolpidem—and major congenital malformations, providing clinical reassurance for managing severe
Processing Speed as a Core Endophenotype: New Evidence from a 115-Study Meta-Analysis in Schizophrenia
A comprehensive meta-analysis involving over 10,000 patients reveals that processing speed impairment is a profound and central deficit in schizophrenia, showing an effect size of -1.52 and playing a critical role in overall cognitive dysfu
Individualized Feedback Letters Fail to Reduce Long-Term Alcohol Consumption: Insights from a 4-Year RCT
A 4-year randomized controlled trial found that computer-generated feedback letters failed to reduce alcohol consumption in the general population. Unexpectedly, the control group showed greater reduction at 48 months, suggesting that curre
Rule-Based Chatbots Outperform LLMs in Depressive Symptom Management: A Systematic Review and Meta-Analysis
A comprehensive meta-analysis indicates that rule-based chatbots provide a modest but statistically significant reduction in depressive symptoms within a 4-8 week window, whereas evidence for the clinical efficacy of Large Language Model (L
Scalable Solutions for Sleep: Converging Evidence from a Nationwide RCT and Meta-Analysis Validates Digital CBT-I
This article analyzes a nationwide decentralized RCT and a systematic meta-analysis to evaluate the efficacy of digital Cognitive Behavioral Therapy for Insomnia (CBT-I), highlighting its role as a scalable, evidence-based first-line treatm
Digital Cognitive Behavioral Therapy for Generalized Anxiety Disorder: Evidence, Impact, and Future Directions
Recent robust randomized trials demonstrate that smartphone-delivered digital cognitive behavioral therapy provides significant, sustained improvements in generalized anxiety disorder, overcoming key access barriers and highlighting its pot
Optimizing Opioid Use Disorder Treatment: When Does 300 mg Outperform 100 mg of Extended-Release Buprenorphine?
This randomized clinical trial compares 100-mg and 300-mg maintenance doses of extended-release buprenorphine. While overall efficacy was similar, the 300-mg dose significantly improved abstinence among patients with high-frequency fentanyl
High-Dose Extended-Release Buprenorphine: A Targeted Strategy for the Fentanyl-Driven Opioid Crisis
This randomized clinical trial compares 100-mg versus 300-mg maintenance doses of extended-release buprenorphine. While overall efficacy was similar, the 300-mg dose significantly improved abstinence rates among heavy fentanyl users, offeri
Transdiagnostic Prediction Model Accurately Identifies Risk for Psychotic and Bipolar Disorders in Clinical Practice
Researchers developed a clinical prediction model using electronic health records from over 127,000 patients to identify individuals at risk of psychotic or bipolar disorders. The model demonstrated high discriminative power (C-index 0.80)
Slow Tapering with Psychological Support Matches Medication Continuation for Relapse Prevention in Remitted Depression
A landmark network meta-analysis demonstrates that slow antidepressant tapering (>4 weeks) combined with psychological support is as effective as drug continuation in preventing relapse, providing a safe, evidence-based pathway for patients
Adolescent Body Dissatisfaction as a Causal Driver of Adult Mental Health: New Insights from a UK Twin Study
A longitudinal UK twin study suggests that adolescent body dissatisfaction may causally increase the risk of eating disorders and depression in young adulthood, with significant genetic factors underlying these associations.
Elevated Serotonin Release in Schizophrenia: New Insights Into Negative Symptom Pathophysiology
A PET imaging study reveals increased frontal serotonin release in schizophrenia, particularly in deficit type, tied to worse negative symptoms.
CBT‑I in Cancer Survivors: Small Subjective Gains, Unclear Objective Benefits — What the 2025 Cochrane Review Tells Clinicians
A 2025 Cochrane review of 21 RCTs (2431 participants) finds cognitive behavioural therapy for insomnia (CBT‑I) yields modest improvements in self‑reported insomnia and sleep quality in people with cancer versus inactive controls or aerobic
Methylphenidate for ADHD in Children and Adolescents: Modest Symptom Gains but Uncertain Net Benefit
Updated Cochrane analysis (212 RCTs, 16,302 participants) finds methylphenidate may reduce teacher-rated ADHD symptoms and improve general behaviour but increases non‑serious adverse events; overall evidence certainty is very low.
Uncertain Evidence for Youth Suicide Interventions: DBT Shows Promise While Medications and Neurotherapies Remain Largely Unstudied
A 2025 systematic review of 65 studies (14,534 youths) finds moderate evidence for dialectical behavior therapy reducing suicidal ideation; other psychosocial interventions have low or insufficient evidence and pharmacologic/neurotherapeuti
Tailored Digital Emotion Regulation Improves Mental Health in Adults With Congenital Heart Disease: Results of a National Randomized Trial
A 3‑arm randomized trial in 524 adults with congenital heart disease found a 4‑week tailored digital emotion‑regulation program produced moderate improvements in emotion regulation and multiple psychosocial outcomes versus usual care; a gen
Late-Onset Depression Risk Persists in Long-Term Breast, Prostate, and Colorectal Cancer Survivors — Who Is Most Vulnerable?
A SEER‑Medicare cohort study found higher 5‑year risk of late-onset depression in breast (13.3%) and colorectal (11.8%) survivors than prostate (8.7%). Dual Medicare‑Medicaid eligibility, preexisting anxiety, and higher comorbidity burden w
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