Psychiatry
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ANK3-Guided Liafensine Shows Clinically Meaningful Benefit in Treatment‑Resistant Depression: Results of the ENLIGHTEN Trial
In ENLIGHTEN, a biomarker-guided randomized trial, ANK3-positive patients with treatment‑resistant depression randomized to liafensine achieved larger MADRS improvements than placebo (mean difference −4.4; 95% CI −7.6 to −1.3; P = .006), wi
High‑Intensity Interval Training Fails to Rescue Hippocampal Integrity in Adults With Cannabis Use Disorder — but Exercise Is Feasible and May Reduce Craving
A randomized trial in adults with moderate–severe cannabis use disorder found 12 weeks of supervised HIIT did not improve a composite MRI measure of hippocampal integrity versus strength/resistance training; exercise participation was feasi
Brief Cognitive Behavioral Therapy Cuts Suicide Attempts in High‑Risk US Military Personnel and Veterans: MSPIRE RCT Confirms Prior Findings
A 2‑arm randomized trial (MSPIRE) found brief cognitive behavioral therapy (BCBT) significantly reduced suicide attempts versus present‑centered therapy in suicidal military personnel and veterans, despite comparable reductions in suicidal
Distinct and Shared Risk Profiles for Suicide Attempt Versus Suicide: Insights from Danish Registers and Genomic Data
A large Danish register and genetic study shows overlapping but distinct environmental and genetic risk factors for nonfatal suicide attempts and death by suicide, with chronic and functional health problems linked more to attempts and seve
Intimacy, Intranasal Oxytocin, and Faster Wound Healing: A Randomized Trial Linking Touch, Sex, and Neuroendocrine Recovery
A double‑blind RCT in 160 healthy adults found that intranasal oxytocin combined with structured positive interaction and daily physical intimacy (affectionate touch, sex) was associated with reduced cortisol and modestly faster dermatologi
Sexual Assault and the Long Shadow of the Body: Higher 5‑Year Risk of Functional Somatic Disorders and Chronic Widespread Pain
A prospective Danish cohort found that adults reporting lifetime sexual assault had substantially higher 5‑year incidence of functional somatic disorders—especially multiorgan FSD and chronic widespread pain—after adjustment for psychosocia
Can Modafinil Break the Sleep–Mood Cycle in People Living with HIV?
Sleep disorders and depression are common in people living with HIV. Modafinil may improve daytime sleepiness, fatigue and cognition—especially for OSA-related EDS or augmentation in depression—but HIV-specific RCT data and ART interaction
Breaking the Cycle: How Modafinil Offers Hope for Sleep and Mood Disorders in HIV Patients
Sleep disturbances and mood disorders profoundly affect people living with HIV. Modafinil emerges as a promising therapy addressing daytime sleepiness, depression, and cognitive challenges, improving quality of life.
Not All Antidepressants Are the Same: Differential Cardiometabolic and Physiological Effects from a Large Network Meta‑analysis
A 151‑trial network meta‑analysis of 58,534 participants shows marked differences among 30 antidepressants in weight, blood pressure, heart rate, lipids, glucose and liver enzymes; findings support individualized choice and targeted baselin
High Burden of ARFID Symptoms in Adults with Disorders of Gut–Brain Interaction: A Population-Based Study Signals Need for Routine Screening
A 2023 population survey of 4,002 adults in the UK and US found that positive screens for avoidant/restrictive food intake disorder (ARFID) were common among people with disorders of gut–brain interaction (DGBI) and associated with greater
Gamma (40 Hz) Sensory Flicker Shows Promise for Insomnia but Needs Controlled Trials
A prospective observational study of 37 adults with insomnia reports high adherence and no serious adverse events with 40 Hz light–sound flicker and sleep-diary improvements in sleep onset, arousals, and total sleep time; limitations includ
How Much Aerobic Exercise Is Enough to Reduce Depression in Patients with Chronic Illness? A Dose–Response Meta-analysis Points to an Achievable Target
A meta-analysis of 36 RCTs (n=2,500) found aerobic exercise significantly reduces depressive symptoms in people with chronic illness (Hedges’ g -0.73). A weekly dose of ≈405 MET‑min (≈120–135 min of moderate aerobic activity) reaches a mini
Persistent Depressive Symptoms After MCI Strongly Predict Progression to Alzheimer’s Disease
In an ADNI longitudinal cohort, persistently elevated depressive symptoms over 36 months after MCI diagnosis were associated with a dose‑dependent, substantially higher hazard of conversion to Alzheimer’s disease over long-term follow-up.
Depression, Anxiety and PTSD Associated With Earlier Onset of Alzheimer’s Disease: Psychiatric Burden Lowers Age at Symptom Onset
In two large Alzheimer cohorts, a history of depression, anxiety, or PTSD and an increased number of psychiatric comorbidities were associated with earlier age at AD symptom onset by up to ~7–8 years for multi-morbidity.
Circadian Dysregulation and Executive Dysfunction in Wolfram Syndrome: Toward Chrono‑Diagnosis and Chronotherapy
Emerging evidence links WFS1-driven ER stress to serotonergic/cholinergic disruption, executive dysfunction, and circadian dysregulation in Wolfram syndrome. This article synthesizes recent data, outlines chrono‑informed clinical assessment
Recent Advances in Alcohol Metabolism: from the Gut to the Brain
This article reviews the latest findings on human alcohol metabolism, covering evolutionary biology, systemic and brain-specific pathways, genetic and physiological modulators, clinical implications of metabolic variability, and emerging th
SPeCIFY: Practical Guidance for Inducing and Measuring Mental Fatigue in Movement Science
Clear, pragmatic recommendations to standardize how mental fatigue is induced, measured and reported in movement-science studies—centered on the SPeCIFY reporting checklist and multi-method assessment.
Group-Based Interventions to Reduce Gambling Involvement Among Male Football Fans
This case report summarizes the feasibility study of a group-based gambling prevention intervention among male football fans, revealing recruitment challenges and insights into intervention delivery within football club contexts.
Understanding Sex- and Age-Specific Suicide Risk Indicators: Insights from a Large Swedish Case-Control Study
This Swedish population-based study highlights how suicide risk indicators vary by sex and age, showing males and older adults exhibit fewer, but often higher absolute risk indicators, underscoring the need for tailored suicide prevention s
Systemic Inflammation as a Modulator of Anhedonia in Major Depressive Disorder: Insights from an LPS Challenge Trial
This RCT reveals that adults with major depressive disorder and elevated systemic inflammation exhibit heightened anhedonic responses to an inflammatory challenge, highlighting inflammation’s role in depression symptomatology.
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