Psychiatry
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Gamma (40 Hz) Sensory Flicker Shows Promise for Insomnia but Needs Controlled Trials
A prospective observational study of 37 adults with insomnia reports high adherence and no serious adverse events with 40 Hz light–sound flicker and sleep-diary improvements in sleep onset, arousals, and total sleep time; limitations includ
How Much Aerobic Exercise Is Enough to Reduce Depression in Patients with Chronic Illness? A Dose–Response Meta-analysis Points to an Achievable Target
A meta-analysis of 36 RCTs (n=2,500) found aerobic exercise significantly reduces depressive symptoms in people with chronic illness (Hedges’ g -0.73). A weekly dose of ≈405 MET‑min (≈120–135 min of moderate aerobic activity) reaches a mini
Persistent Depressive Symptoms After MCI Strongly Predict Progression to Alzheimer’s Disease
In an ADNI longitudinal cohort, persistently elevated depressive symptoms over 36 months after MCI diagnosis were associated with a dose‑dependent, substantially higher hazard of conversion to Alzheimer’s disease over long-term follow-up.
Depression, Anxiety and PTSD Associated With Earlier Onset of Alzheimer’s Disease: Psychiatric Burden Lowers Age at Symptom Onset
In two large Alzheimer cohorts, a history of depression, anxiety, or PTSD and an increased number of psychiatric comorbidities were associated with earlier age at AD symptom onset by up to ~7–8 years for multi-morbidity.
Circadian Dysregulation and Executive Dysfunction in Wolfram Syndrome: Toward Chrono‑Diagnosis and Chronotherapy
Emerging evidence links WFS1-driven ER stress to serotonergic/cholinergic disruption, executive dysfunction, and circadian dysregulation in Wolfram syndrome. This article synthesizes recent data, outlines chrono‑informed clinical assessment
Recent Advances in Alcohol Metabolism: from the Gut to the Brain
This article reviews the latest findings on human alcohol metabolism, covering evolutionary biology, systemic and brain-specific pathways, genetic and physiological modulators, clinical implications of metabolic variability, and emerging th
SPeCIFY: Practical Guidance for Inducing and Measuring Mental Fatigue in Movement Science
Clear, pragmatic recommendations to standardize how mental fatigue is induced, measured and reported in movement-science studies—centered on the SPeCIFY reporting checklist and multi-method assessment.
Group-Based Interventions to Reduce Gambling Involvement Among Male Football Fans
This case report summarizes the feasibility study of a group-based gambling prevention intervention among male football fans, revealing recruitment challenges and insights into intervention delivery within football club contexts.
Understanding Sex- and Age-Specific Suicide Risk Indicators: Insights from a Large Swedish Case-Control Study
This Swedish population-based study highlights how suicide risk indicators vary by sex and age, showing males and older adults exhibit fewer, but often higher absolute risk indicators, underscoring the need for tailored suicide prevention s
Systemic Inflammation as a Modulator of Anhedonia in Major Depressive Disorder: Insights from an LPS Challenge Trial
This RCT reveals that adults with major depressive disorder and elevated systemic inflammation exhibit heightened anhedonic responses to an inflammatory challenge, highlighting inflammation’s role in depression symptomatology.
Unraveling Genetic Links Between Problematic Alcohol Use and Psychiatric Disorders: Insights from Large-Scale Genomic Analyses
This study reveals significant shared genetic architectures between problematic alcohol use and various psychiatric disorders, identifying key genes like TTC12 and ANKK1 that may underlie their comorbidity.
Cognitive Control Deficits in Specific Problematic Internet Uses: Insights From Clinically Validated Neurocognitive Assessments
This study reveals distinct impairments in executive functions and inhibitory control across types of problematic internet use, highlighting the need for tailored interventions to address self-control deficits in internet addiction.
Polygenic Influences and Anticholinergic Burden: Unraveling Their Joint Impact on Cognition and Brain Structure in Psychosis Spectrum Disorders
This study reveals that genetic predispositions interact with anticholinergic medication burden to influence cognitive deficits and brain gray matter volume reductions in psychosis spectrum disorders, offering new insights into personalized
Cognition-Guided EEG Neurofeedback Enhances Response Inhibition in Methamphetamine Use Disorder: A Promising Neuromodulation Approach
Cognition-guided EEG neurofeedback targeting methamphetamine cue-related brain activity significantly improves response inhibition in men with methamphetamine use disorder, surpassing standard rehabilitation outcomes and offering a novel in
Telehealth Prescribing of ADHD Stimulants: Assessing Risks for Subsequent Substance Use Disorders
This study evaluates whether initiating ADHD stimulant prescriptions via telehealth affects later risks of stimulant or other substance use disorders, finding no SUD risk increase but a potential rise in stimulant use disorder risk.
Unveiling the Impact of Copy Number Variants on Child Psychopathology and Cognitive Development: Insights from the ABCD Study
This study elucidates how copy number variants (CNVs) contribute to variability in child psychopathology and cognitive function, highlighting specific CNV regions and aggregated genetic risk affecting attention and cognitive domains during
Treatment Retention in Opioid Use Disorder During Pregnancy: Buprenorphine vs Methadone Discontinuation Patterns
This nationwide cohort study reveals higher discontinuation rates of buprenorphine than methadone during pregnancy and up to one year postpartum, highlighting significant challenges in treatment retention for opioid use disorder in pregnant
Reduced Brain Iron Linked to Striatal Hyperdopaminergia in Schizophrenia: Insights from QSM MRI and PET Imaging
This study reveals that lower brain iron levels in the substantia nigra-ventral tegmental area are associated with elevated striatal dopamine synthesis in schizophrenia, highlighting a potential new target for therapeutic intervention.
Neighborhood Social Vulnerability and Racial Disparities in Schizophrenia Spectrum Disorder Prevalence: Insights from a National US Study
This national study reveals significant ethnoracial disparities in schizophrenia spectrum disorders prevalence linked to neighborhood social vulnerability, highlighting structural racism’s role in mental health inequities among non-Hispanic
Unveiling the Iron-Dopamine Link in Schizophrenia: Insights from QSM MRI and PET Imaging
This study reveals reduced brain iron in the substantia nigra-ventral tegmental area correlating with increased striatal dopamine synthesis in schizophrenia, suggesting novel neurobiological mechanisms and potential therapeutic targets.
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