Psychiatry
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Unraveling Genetic Links Between Problematic Alcohol Use and Psychiatric Disorders: Insights from Large-Scale Genomic Analyses
This study reveals significant shared genetic architectures between problematic alcohol use and various psychiatric disorders, identifying key genes like TTC12 and ANKK1 that may underlie their comorbidity.

Cognitive Control Deficits in Specific Problematic Internet Uses: Insights From Clinically Validated Neurocognitive Assessments
This study reveals distinct impairments in executive functions and inhibitory control across types of problematic internet use, highlighting the need for tailored interventions to address self-control deficits in internet addiction.

Polygenic Influences and Anticholinergic Burden: Unraveling Their Joint Impact on Cognition and Brain Structure in Psychosis Spectrum Disorders
This study reveals that genetic predispositions interact with anticholinergic medication burden to influence cognitive deficits and brain gray matter volume reductions in psychosis spectrum disorders, offering new insights into personalized

Cognition-Guided EEG Neurofeedback Enhances Response Inhibition in Methamphetamine Use Disorder: A Promising Neuromodulation Approach
Cognition-guided EEG neurofeedback targeting methamphetamine cue-related brain activity significantly improves response inhibition in men with methamphetamine use disorder, surpassing standard rehabilitation outcomes and offering a novel in

Telehealth Prescribing of ADHD Stimulants: Assessing Risks for Subsequent Substance Use Disorders
This study evaluates whether initiating ADHD stimulant prescriptions via telehealth affects later risks of stimulant or other substance use disorders, finding no SUD risk increase but a potential rise in stimulant use disorder risk.

Unveiling the Impact of Copy Number Variants on Child Psychopathology and Cognitive Development: Insights from the ABCD Study
This study elucidates how copy number variants (CNVs) contribute to variability in child psychopathology and cognitive function, highlighting specific CNV regions and aggregated genetic risk affecting attention and cognitive domains during

Treatment Retention in Opioid Use Disorder During Pregnancy: Buprenorphine vs Methadone Discontinuation Patterns
This nationwide cohort study reveals higher discontinuation rates of buprenorphine than methadone during pregnancy and up to one year postpartum, highlighting significant challenges in treatment retention for opioid use disorder in pregnant

Reduced Brain Iron Linked to Striatal Hyperdopaminergia in Schizophrenia: Insights from QSM MRI and PET Imaging
This study reveals that lower brain iron levels in the substantia nigra-ventral tegmental area are associated with elevated striatal dopamine synthesis in schizophrenia, highlighting a potential new target for therapeutic intervention.

Neighborhood Social Vulnerability and Racial Disparities in Schizophrenia Spectrum Disorder Prevalence: Insights from a National US Study
This national study reveals significant ethnoracial disparities in schizophrenia spectrum disorders prevalence linked to neighborhood social vulnerability, highlighting structural racism’s role in mental health inequities among non-Hispanic

Unveiling the Iron-Dopamine Link in Schizophrenia: Insights from QSM MRI and PET Imaging
This study reveals reduced brain iron in the substantia nigra-ventral tegmental area correlating with increased striatal dopamine synthesis in schizophrenia, suggesting novel neurobiological mechanisms and potential therapeutic targets.

Assessing Nearly Five Years of Real-World Safety Data on Esketamine Nasal Spray in the United States
A comprehensive evaluation of nearly five years of esketamine nasal spray use confirms its safety profile consistent with clinical trials, with no new safety signals detected in over 1.4 million treatment sessions.

Unraveling Depressive Symptom Trajectories in Early Adolescents: Insights from a 12-Month Cohort in Nanchong, China
This longitudinal study reveals distinct trajectories of depressive symptoms among Chinese adolescents, highlighting key sociodemographic and behavioral predictors that can inform early intervention strategies.

Harnessing Effective Connectivity Between Cerebellum and Fronto-Temporal Regions for Objective Major Depressive Disorder Diagnosis: Insights From a Multi-Site fMRI Study
A multi-site fMRI study demonstrates that effective connectivity patterns between the cerebellum and fronto-temporal areas accurately classify major depressive disorder with over 94% accuracy, offering a promising neuroimaging biomarker to

Unraveling Ovarian Steroid Impacts in PMDD: Insights from Expanded Hormone Addback Study
This study clarifies how estradiol and progesterone differentially affect symptoms in PMDD, confirming symptom remission during ovarian suppression and distinct hormonal triggers in affected women versus healthy controls.

Reduced Threat-Related Neural Efficiency as a Biomarker for Pediatric Anxiety: Implications for Diagnosis and CBT Response
This study identifies reduced neural efficiency during threat processing as a biomarker in pediatric anxiety disorders, linked to diagnosis and poorer CBT outcomes, offering potential for patient stratification and novel intervention target

Defining Relapse in Schizophrenia: New International Consensus to Standardize Research and Care
An international expert consensus offers standardized, operational criteria for defining relapse in schizophrenia to reduce study heterogeneity, improve research comparability, and guide clinical reporting.

Decoding the Genetic Complexity of Impulsivity and Its Neurodevelopmental Impact
This study reveals the heterogeneous genetic architecture of impulsivity, uncovering diverse biological pathways linking it to neurodevelopment and psychopathology across the lifespan.

Comparative Efficacy and Tolerability of Seven Antipsychotics in Acute Schizophrenia: Insights from a Large Multicenter Randomized Trial
A multicenter randomized trial comparing seven antipsychotics in acute schizophrenia shows olanzapine and risperidone outperform several agents in efficacy but differ markedly in side effects, clarifying treatment choices.

Grip Strength as an Indicator of Brain Network Integrity and Well-Being in Early Psychosis
This study links diminished grip strength in early psychosis to altered resting-state brain connectivity within key networks, suggesting grip strength as a potential marker for neural integrity and overall well-being in psychotic disorders.

Neurobiological Impact of Emotion-Focused Parenting Intervention in Adolescent Girls With Internalizing Symptoms: Insights From a Randomized Clinical Trial
An emotion-focused parenting intervention improves prefrontal cortex activation during emotion regulation in adolescent girls with internalizing symptoms, correlating with reductions in maternal unsupportive socialization and adolescent anx
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