Psychiatry
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High-Dose Extended-Release Buprenorphine: A Targeted Strategy for the Fentanyl-Driven Opioid Crisis
This randomized clinical trial compares 100-mg versus 300-mg maintenance doses of extended-release buprenorphine. While overall efficacy was similar, the 300-mg dose significantly improved abstinence rates among heavy fentanyl users, offeri
Transdiagnostic Prediction Model Accurately Identifies Risk for Psychotic and Bipolar Disorders in Clinical Practice
Researchers developed a clinical prediction model using electronic health records from over 127,000 patients to identify individuals at risk of psychotic or bipolar disorders. The model demonstrated high discriminative power (C-index 0.80)
Slow Tapering with Psychological Support Matches Medication Continuation for Relapse Prevention in Remitted Depression
A landmark network meta-analysis demonstrates that slow antidepressant tapering (>4 weeks) combined with psychological support is as effective as drug continuation in preventing relapse, providing a safe, evidence-based pathway for patients
Adolescent Body Dissatisfaction as a Causal Driver of Adult Mental Health: New Insights from a UK Twin Study
A longitudinal UK twin study suggests that adolescent body dissatisfaction may causally increase the risk of eating disorders and depression in young adulthood, with significant genetic factors underlying these associations.
Elevated Serotonin Release in Schizophrenia: New Insights Into Negative Symptom Pathophysiology
A PET imaging study reveals increased frontal serotonin release in schizophrenia, particularly in deficit type, tied to worse negative symptoms.
CBT‑I in Cancer Survivors: Small Subjective Gains, Unclear Objective Benefits — What the 2025 Cochrane Review Tells Clinicians
A 2025 Cochrane review of 21 RCTs (2431 participants) finds cognitive behavioural therapy for insomnia (CBT‑I) yields modest improvements in self‑reported insomnia and sleep quality in people with cancer versus inactive controls or aerobic
Methylphenidate for ADHD in Children and Adolescents: Modest Symptom Gains but Uncertain Net Benefit
Updated Cochrane analysis (212 RCTs, 16,302 participants) finds methylphenidate may reduce teacher-rated ADHD symptoms and improve general behaviour but increases non‑serious adverse events; overall evidence certainty is very low.
Uncertain Evidence for Youth Suicide Interventions: DBT Shows Promise While Medications and Neurotherapies Remain Largely Unstudied
A 2025 systematic review of 65 studies (14,534 youths) finds moderate evidence for dialectical behavior therapy reducing suicidal ideation; other psychosocial interventions have low or insufficient evidence and pharmacologic/neurotherapeuti
Tailored Digital Emotion Regulation Improves Mental Health in Adults With Congenital Heart Disease: Results of a National Randomized Trial
A 3‑arm randomized trial in 524 adults with congenital heart disease found a 4‑week tailored digital emotion‑regulation program produced moderate improvements in emotion regulation and multiple psychosocial outcomes versus usual care; a gen
Late-Onset Depression Risk Persists in Long-Term Breast, Prostate, and Colorectal Cancer Survivors — Who Is Most Vulnerable?
A SEER‑Medicare cohort study found higher 5‑year risk of late-onset depression in breast (13.3%) and colorectal (11.8%) survivors than prostate (8.7%). Dual Medicare‑Medicaid eligibility, preexisting anxiety, and higher comorbidity burden w
School Feeding Programs: Comprehensive Evidence on Benefits for Socioeconomically Disadvantaged School Children’s Physical and Psychological Health
This review synthesizes global evidence, including meta-analyses, showing that school feeding programs modestly improve math achievement, enrollment, and growth metrics in socioeconomically disadvantaged children, with limited effects on re
Clozapine Works Beyond Schizophrenia: Nationwide Evidence for Transdiagnostic Effectiveness and Safety
Large Finnish and Swedish registry cohorts show clozapine is associated with lower psychiatric hospitalisation across schizophrenia-spectrum, bipolar disorder and severe depression without increased overall mortality or hospitalisation.
Large Phase 3 Trials Show No Cognitive Benefit with Iclepertin in Schizophrenia — What the CONNEX Programme Teaches Us About Treating CIAS
Three multinational phase 3 trials found no clinically meaningful cognitive benefit of the GlyT1 inhibitor iclepertin versus placebo in schizophrenia, though the drug was well tolerated. Results highlight methodological and biological chall
Psychedelics and MDMA for Mental Disorders: Promising Large Effects but Limited Certainty—What the Latest Living Meta-analysis Shows
A living systematic review of 30 RCTs (n=1,480) finds moderate-to-large symptom reductions for MDMA in PTSD and serotonergic psychedelics in major depression and anxiety, but high risk of bias and low certainty overall; pragmatic, longer, a
Peer Self-harm Predicts a Small Increase in Adolescent Risk with a Peak at Age 16: Findings from a Nationwide Finnish Cohort
A Finnish registry cohort (n=913,149) found that exposure to same-grade schoolmates’ self-harm modestly increased later self-harm risk (HR 1.05), with the largest effect around age 16 (HR ~1.45), suggesting time-limited social transmission
Urban Greenness Associated with Fewer Mental-Health Hospital Admissions — But Effects Vary Across Countries
A multinational time-series analysis of 11.4 million admissions found that higher neighbourhood greenness (NDVI) was linked to lower hospital admissions for mental disorders overall, with heterogeneity across countries and disorder types an
Metformin Moderately Reduces Antipsychotic-Related Weight Gain in Youth with Bipolar Spectrum Disorders: Large Pragmatic 24‑Month Trial Supports Clinical Use
A 1,565‑participant pragmatic randomized trial shows metformin added to lifestyle counseling produced modest but statistically significant reductions in BMI Z-score at 6 and 24 months in overweight/obese children and adolescents with bipola
Metformin Modestly Reduces Antipsychotic-Associated Weight Gain in Youth with Bipolar Spectrum Disorders — Large Pragmatic Trial Supports Consideration in Practice
A large, pragmatic randomized trial found that adjunctive metformin produced a modest but statistically significant reduction in BMI Z-score at 6 and 24 months among overweight and obese youth with bipolar spectrum disorders treated with se
Stopping Smoking Is Associated With Better Recovery From Other Substance Use Disorders: Longitudinal Evidence From a US National Cohort
A longitudinal, nationally representative cohort study found that within-person transition from current to former cigarette smoking was associated with a 30–43% higher odds of sustained recovery from other substance use disorders, supportin
Collaborative Care for OUD in Primary Care Reduces Opioid Use: Cluster RCT Shows Added Benefit from an OUD-Focused Model
A pragmatic cluster randomized trial found that adding OUD-specific components to collaborative care in primary care clinics reduced days of opioid use more than collaborative care for mental health alone, without clear additional mental he
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