Otorhinolaryngology
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Active Surveillance Superior to Surgery for Quality of Life in Low-Risk Thyroid Cancer: Insights from a Global Meta-Analysis
A comprehensive meta-analysis demonstrates that patients with papillary thyroid microcarcinoma managed via active surveillance experience significantly better health-related quality of life and fewer treatment-related symptoms than those un
Thyroid Lobectomy and Neck Dissection Offer Comparable Survival to Total Thyroidectomy in Selected N1b Papillary Thyroid Carcinoma
A landmark propensity-matched study from Memorial Sloan Kettering Cancer Center demonstrates that thyroid lobectomy with neck dissection provides similar survival and recurrence outcomes to total thyroidectomy plus radioactive iodine for sp
Pathologic Response Predicts Disease-Free Survival in Neoadjuvant Immunotherapy for Mucosal HNSCC
A meta-analysis of 11 trials shows that partial and major pathologic responses after neoadjuvant immunotherapy significantly correlate with improved disease-free survival in mucosal HNSCC, suggesting these metrics serve as viable surrogate
Shared Decision-Making with Otolaryngologists and Palliative Care Specialists Enhances Multidisciplinary Support in Advanced Oral Cavity Cancer
A prospective cohort study demonstrates that a structured shared decision-making (SOP) model significantly increases the utilization of multidisciplinary palliative care services for patients with stage IV oral cavity cancer, bridging the g
Integrated Multidisciplinary Care Slashes Radiotherapy Interruptions in Head and Neck Cancer: Results from the SHINE-MDT Randomized Trial
A randomized clinical trial demonstrates that the SHINE-MDT framework significantly reduces radiotherapy interruptions and improves nutritional, psychological, and quality-of-life outcomes for patients with head and neck cancer, offering a
Biofeedback vs Respiratory Retraining: No Significant Difference in Inducible Laryngeal Obstruction Relief
A pilot trial finds biofeedback and respiratory retraining equally effective for inducible laryngeal obstruction, offering clinicians flexible, patient-tailored options.
Your Nose Knows: How Smell Loss Signals More Than a Cold — Links to 139 Diseases and What to Do About It
A large prospective study links smell disturbances to at least 139 conditions. Olfactory loss can be an early sign of neurological, ENT, metabolic, or systemic disease — and a practical, underused screening tool clinicians can adopt.
Radiotherapy Interruptions in Head and Neck Cancer Raise Risk of Locoregional Failure and Death — Impact Depends on p16 Status and Stage
Secondary analysis of three RTOG/NRG trials shows radiotherapy interruptions are associated with higher locoregional failure and worse overall survival in head and neck cancer, with larger absolute harms in p16‑negative and high‑stage disea
Clinical Findings and Molecular Genetics of USH1C-Associated Usher Syndrome: A Retrospective Case Series
This case series reviews clinical features, genetic variants, visual outcomes, and psychosocial impact in 28 patients with USH1C-associated Usher syndrome, highlighting slow retinal degeneration and significant social burden.
Higher Osteoradionecrosis Risk After Proton Therapy than IMRT in Oropharyngeal Cancer — What Clinicians Should Know
In a large single‑institution cohort of oropharyngeal squamous cell carcinoma, proton therapy was associated with a higher 3‑year rate of osteoradionecrosis than IMRT (6.4% vs 2.7%), though severe ORN remained uncommon.
Engasertib Shows Promise for Reducing Epistaxis in HHT but Benefits Are Modest — Safety Profile Acceptable in Short Term
A randomized, double-blind placebo-controlled proof-of-concept trial of engasertib (AKT inhibitor) in hereditary hemorrhagic telangiectasia showed modest reductions in epistaxis frequency and duration versus placebo and a tolerable safety p
Engasertib Shows Promise for Recurrent Epistaxis in HHT: Proof‑of‑Concept Trial Demonstrates Reduced Bleeding with Acceptable Short‑Term Safety
In a randomized, double‑blind, placebo‑controlled proof‑of‑concept trial, oral engasertib reduced epistaxis frequency and duration in hereditary hemorrhagic telangiectasia (HHT) with a safety profile similar to placebo except for reversible
More Than Half of Hispanic Medicare Beneficiaries Aged 65+ Have Hearing Loss — Yet Few Use Hearing Aids
A nationally representative 2022 study found hearing loss in 54.6% of Hispanic US adults 65+; only 8.3% of those with hearing loss reported using hearing aids, underscoring major access gaps.
Severe Late Radiation Toxicities in Head and Neck Cancer: Common, Preventable, and Linked to Worse Survival
A large single-center cohort (n=7,622) shows 12.6% of head and neck cancer patients develop severe (≥RTOG grade 3) radiation-related late toxicities; modifiable factors and specialized multidisciplinary late-effects care may reduce risk and
One in Three Head and Neck Cancer Survivors Still Have Supportive Care Needs at Five Years — Fear of Recurrence and Pain Drive Long-Term Demand
Longitudinal data from 403 head and neck cancer survivors show that while information and health-system needs decline between years 2 and 5, one-third report at least one moderate-to-high unmet supportive care need at year 5—notably fatigue
Half of Long‑Term Head and Neck Cancer Survivors Report Unmet Supportive Care Needs — A Multinational Cohort Highlights Clinical and System Drivers
A multinational cross‑sectional study of 1,097 head and neck cancer survivors >5 years after diagnosis found that ~50% report moderate‑to‑high unmet supportive care needs, driven by HNC‑specific, psychological and physical/daily living conc
Preoperative Clues That Predict Who Will Receive Adjuvant Therapy After Surgery for Oral Cavity Cancer
In a multicenter cohort of 3,980 oral cavity squamous cell carcinoma patients, preoperative clinical and tumor features—including age, comorbidity, tumor subsite, size, clinical stage, and biopsy grade—predicted receipt and intensity of adj
Updated Basal Calcitonin Cutoffs Predict Extent of Lymph Node Metastasis in Medullary Thyroid Cancer — Practical Thresholds for Surgery Planning
A multicenter Chinese cohort of 509 initially treated MTC patients identifies new preoperative basal calcitonin thresholds (241.9, 693.9, 2378.5, 2787.1 pg/mL) that better predict central, ipsilateral lateral, bilateral/contralateral latera
HNC-8D: A Head and Neck Cancer–Specific Utility Measure That Improves Discrimination of Post‑treatment Health States
A multinational team developed and valued the HNC-8D, an 8-dimension, head and neck cancer–specific health utility instrument derived from EORTC QLQ-C30/H&N43. Valuation in 250 participants yielded mean absolute prediction errors of 0.041 (
Myocardial Injury Is Common After Major Head and Neck Surgery and Predicts Early Mortality: Insights from the VISION Cohort
A VISION cohort analysis found myocardial injury after major head and neck surgery (MINS) in 11.9% overall and 23.8% of patients ≥75, strongly associated with 30‑day mortality and longer hospital stay; most events were clinically silent wit
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