Otorhinolaryngology
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AAV‑OTOF Gene Therapy Restores Substantial Hearing in DFNB9 Across Ages — Rapid, Age‑dependent Benefits in a First-in‑Human Trial
A single‑arm trial of AAV‑OTOF (Anc80L65) in 10 patients (1.5–23.9 years) with autosomal recessive deafness 9 showed good tolerability and rapid, clinically meaningful hearing gains, with optimal outcomes in children aged 5–8 years; longer
OTOF Gene Therapy Rivaled—and in Some Domains Outperformed—Cochlear Implants in Restoring Hearing and Speech in Congenital Deafness
A 2022–2024 nonblinded cohort study found OTOF gene therapy produced rapid, durable gains in auditory thresholds, speech perception, mismatch-negativity responses, and music perception versus cochlear implantation in children with genetical
Fast versus Slow Compression in Hearing Aids: Hearing Thresholds Predict Preference but Not Speech Outcomes
A randomized crossover trial in older adults found that hearing-loss severity — not cognition or prior hearing-aid experience — predicts preference for slow versus fast compression; speech recognition in quiet and noise was unchanged by com
Unilateral Pediatric Chronic Otitis Media with Effusion Impairs Binaural Hearing and Raises Tinnitus Risk: Evidence Challenging Conservative Management
A prospective cross-sectional study finds unilateral chronic otitis media with effusion (COME) in children is associated with poorer spatial release from masking and high tinnitus prevalence, suggesting potential central auditory consequenc
NLRP3 Inflammasome in Hearing Loss: Mechanisms and Emerging Therapeutic Strategies
The NLRP3 inflammasome plays a central role in inflammation-mediated sensorineural hearing loss (SNHL). Genetic and acquired activation causes cochlear damage through cytokine release and pyroptosis. Targeted therapies, including IL-1 block
Hearing Aids Improve Some Aspects of Socio-Emotional Well‑being — But Not All: Insights from the WHAM Longitudinal Study
The WHAM longitudinal study finds modest psychosocial benefits from hearing‑aid uptake—reduced depression in people without tinnitus and lower loneliness in older adults—while showing limited mediation by self-perceived hearing disability a
Lower, More Frequent Cisplatin Dosing Substantially Reduces Hearing Loss in Head and Neck Cancer Without Compromising Short‑Term Survival
A multicenter retrospective cohort shows weekly low‑dose cisplatin markedly lowers ototoxicity compared with standard high‑dose every‑3‑week cisplatin in CRT for head and neck squamous cell carcinoma, with similar two‑year survival.
Cochlear Implant Benefits in Children with Single‑Sided Deafness: Better in Quiet, Challenged in Noise — and Time Matters
In 185 children receiving unilateral cochlear implants, residual acoustic hearing favored the non-implanted ear in quiet (especially for SSD), but noise attenuated that advantage. Shorter auditory deprivation and longer CI experience reduce
Longitudinal Developmental Outcomes and Early Cochlear Implantation Benefits in Children with Prelingual Single-Sided Deafness: Evidence Synthesis and Clinical Recommendations
Early cochlear implantation in children with prelingual single-sided deafness improves spatial hearing and cognitive outcomes, supporting neurodevelopment and mitigating risks of auditory deprivation and cortical reorganization.
Early Cochlear Implantation Shows Variable but Clinically Relevant Benefits in Children with Single-Sided Deafness: A Western Australian 10‑Year Series
A retrospective 10‑year series from Perth Children’s Hospital reports heterogeneous long‑term outcomes after pediatric cochlear implantation for single‑sided deafness; earlier implantation (within 1 year) was associated with greater likelih
Pre-Fitting Predictors of 2‑Year Hearing Aid Use in 284,175 US Veterans: When Patient Context Matters More Than Audiometry
In 284,175 US veterans, nonmodifiable pre‑fitting factors—health comorbidity, mental status, prior hearing‑aid experience, age, race/ethnicity, and partnership—were independently associated with 2‑year hearing‑aid use persistence, beyond au
Hearing Loss Delays Semantic Prediction When Listening Is Demanding: Two-Stage Prediction Impaired by Cognitive Load
A visual-world eye-tracking study in older adults shows that postlingual hearing loss delays verb-driven semantic prediction—especially under higher listening demand—while simple agent-based prediction is preserved.
Type 2 Diabetes Quadruples Risk of Hearing Loss — Meta-analysis Finds Predominant High-Frequency Impairment and Links to Duration and HbA1c
A PRISMA systematic review and meta-analysis of 17 studies (2019–2024) found type 2 diabetes is associated with a 4.19-fold greater odds of hearing loss, especially at high frequencies; duration >10 years and higher HbA1c amplified risk.
DB-OTO Restores and Sustains Hearing in Otoferlin-Deficient Mice: A Hair-Cell–Targeted Dual-AAV Strategy Advances to Clinical Testing
DB-OTO, a hair-cell-specific dual-AAV gene therapy encoding full-length human otoferlin, achieved dose-dependent and sustained auditory restoration in OTOF-deficient mice, supporting an ongoing Phase I/II pediatric trial.
Epstein-Barr Virus Serology as a Predictor of Persistent Oral HPV Infection in Men: Insights From the Finnish Family HPV Study
A Finnish longitudinal study reveals that elevated Epstein-Barr virus antibody levels are significantly associated with persistent oral HPV infections, highlighting potential viral interplay in oropharyngeal oncogenesis risk.
Evaluating Atezolizumab Maintenance Therapy in High-Risk Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Insights from the IMvoke010 Trial
Atezolizumab maintenance therapy after multimodal definitive treatment failed to improve event-free or overall survival in high-risk LA SCCHN patients in the phase 3 IMvoke010 trial, highlighting challenges in immunotherapy for this setting
DB-OTO Gene Therapy: A Breakthrough Treatment for OTOF-Related Inherited Deafness in Children
Regeneron’s DB-OTO gene therapy shows promising results in restoring natural hearing in children with profound hearing loss caused by OTOF gene mutations, with 75% achieving significant hearing improvement after a single treatment.
Gender Differences in Chronic Rhinosinusitis: Insights into Diagnosis and Biomarkers
This study explores how biological sex influences CRS diagnosis and inflammatory biomarkers, revealing sex-specific patterns that could inform personalized treatment.
Long-Term Outcomes of Oral Implant Rehabilitation in Patients with Disabilities Under General Anesthesia: A 14-Year Cohort Study
This study evaluates the safety, effectiveness, and longevity of implant-supported prostheses in disabled patients treated under general anesthesia over 14 years.
Enhancing Oral Function through Long-Term Rehabilitation in Tongue and Non-Tongue Cancer Patients
This review examines a study on the long-term impact of an oral rehabilitation program on patients with and without tongue cancer, highlighting benefits and clinical implications.
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