Otorhinolaryngology
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Celecoxib Cuts Opioid Use Nearly in Half After Throat Surgery—Without Increasing Pain
A retrospective cohort study of 80 patients undergoing tonsillectomy, adenoidectomy, or uvulopalatopharyngoplasty found that adding celecoxib to multimodal analgesia reduced mean opioid consumption by 44%, while maintaining comparable pain
Liquid Biopsy Predicts Recurrence in HPV-Independent Head and Neck Cancer Months Before Imaging
A prospective study demonstrates that tumor-informed ctDNA-based minimal residual disease (MRD) testing significantly predicts recurrence and survival in HPV-independent HNSCC, offering a median five-month lead time over clinical detection
In-Lab vs. At-Home Sleep Studies: Determining Minimum Recording Time and the Role of Positional Sleep Apnea
This study compares in-lab and home sleep tests, revealing that in-lab polysomnography requires at least 6 hours of recording for accuracy, while home tests need only 3 hours, particularly due to the variables introduced by positional obstr
Long-Term Survival Milestones in Metastatic Nasopharyngeal Carcinoma: A Comprehensive Review of the 5-Year CAPTAIN-1st Data
This review analyzes the 5-year overall survival outcomes of the CAPTAIN-1st trial, establishing camrelizumab plus chemotherapy as a long-term standard of care for recurrent or metastatic nasopharyngeal carcinoma.
Sentinel Lymph Node Biopsy in Head and Neck Merkel Cell Carcinoma: Why High False-Negative Rates Demand Clinical Vigilance
A comprehensive cohort study reveals that sentinel lymph node biopsy (SLNB) in head and neck Merkel cell carcinoma has a sensitivity of only 52.6% and a high failure rate. The findings suggest that clinicians must reconsider management stra
Head and Neck Metastases From Infraclavicular Primary Tumors: Analysis of 136 Cases
This clinical analysis of 136 patients highlights that head and neck metastases often serve as the primary manifestation of infraclavicular cancers, emphasizing the diagnostic value of cervical lymph nodes.
Molecular Profiling of Benign Vocal Fold Lesions: Differential Gene Expression in Polyps versus Reinke’s Edema
This review explores the transcriptomic distinctions between vocal fold polyps and Reinke’s edema, focusing on the upregulation of COL1A1, FN1, and MMP-9 in polyps as key diagnostic and mechanistic markers.
A New Standard for Pediatric Vocal Fold Immobility After Cardiac Surgery: Improving Outcomes Through Injection Laryngoplasty
Recent research highlights a standardized multidisciplinary protocol for managing unilateral vocal fold immobility in infants after cardiothoracic surgery, showing that injection laryngoplasty significantly improves oral feeding advancement
Beyond the Bloat: Addressing the Neuropsychiatric Burden of Retrograde Cricopharyngeus Dysfunction through Targeted Botulinum Toxin Intervention
This review analyzes the high prevalence of anxiety and depression in patients with Retrograde Cricopharyngeus Dysfunction (RCPD) and evaluates the significant, sustained mental health improvements following cricopharyngeal botulinum toxin
Long-Term Survival Outweighs Short-Term Quality of Life: Why Esophagectomy Remains the Gold Standard for Esophageal Cancer Responders
A decision analytical model reveals that while active surveillance offers short-term quality-of-life benefits, standard esophagectomy provides superior 5-year survival and quality-adjusted life-years (QALYs) for esophageal cancer patients a
Targeted Postoperative Exercises Significantly Accelerate Swallowing Recovery and Enhance Quality of Life After Thyroidectomy
A randomized controlled trial demonstrates that a 3-month standardized neck and orofacial rehabilitation program significantly improves swallowing-related quality of life and functional recovery in post-thyroidectomy patients, effectively a
Long-Term Survival Gains with Tislelizumab: Redefining First-Line Therapy for Metastatic Nasopharyngeal Carcinoma
The 3-year follow-up of the RATIONALE-309 trial demonstrates that first-line tislelizumab plus chemotherapy significantly improves overall survival (45.3 months) in recurrent or metastatic nasopharyngeal carcinoma, identifying B-cell signat
Surgical Management of Sporadic Medullary Thyroid Cancer: Evidence-Based Comparison of Total Thyroidectomy vs Lobectomy
This systematic review and meta-analysis suggests that thyroid lobectomy may offer comparable oncologic outcomes to total thyroidectomy for selected patients with sporadic medullary thyroid cancer, while significantly reducing postoperative
Beyond Objective Responses: Amivantamab Demonstrates Significant Clinical Benefit in Recurrent Adenoid Cystic Carcinoma
A Phase 2 clinical trial of amivantamab, an EGFR-MET bispecific antibody, in recurrent or metastatic adenoid cystic carcinoma (ACC) showed a 72.2% clinical benefit rate. While the primary objective response rate was low, the high rate of di
Three-Year RATIONALE-309 Data Confirm Sustained Survival Benefit of First-Line Tislelizumab in Nasopharyngeal Carcinoma
Long-term results from the RATIONALE-309 trial show tislelizumab plus chemotherapy significantly improves survival in recurrent or metastatic nasopharyngeal carcinoma, establishing a durable therapeutic standard and identifying B-cell signa
Redefining the Standard of Care in High-Risk Resected SCCHN: Insights from the GORTEC 2018-01 NIVOPOST-OP Trial
This review analyzes the Phase 3 NIVOPOST-OP trial, demonstrating that adding nivolumab to postoperative chemoradiotherapy significantly improves disease-free survival in high-risk SCCHN patients, establishing a potential new therapeutic st
Optimizing Prognosis: The New AJCC Version 9 Staging for Salivary Gland Carcinoma
The proposed AJCC/UICC Version 9 staging for salivary gland carcinoma shifts toward a unified, specific system using lymph node count and extranodal extension, significantly improving prognostic accuracy for both major and minor salivary gl
Pembrolizumab Dominates the HNC Market While Immune-Related Adverse Events Persist in Real-World Practice
A large-scale cohort study of 47,365 head and neck cancer patients reveals a significant market shift toward pembrolizumab and a 41.2% incidence of immune-related adverse events, though severe toxicities remain rare and are linked to specif
PTH-Guided Selective Calcium Supplementation After Total Thyroidectomy: Is Routine Prophylaxis Still Necessary?
A multicenter randomized clinical trial demonstrates that selective calcium supplementation based on early postoperative PTH levels is as effective as routine prophylaxis in preventing hypocalcemia after total thyroidectomy, offering a stra
Thyroidectomy in Older Adults: Are Increased Relative Risks a Barrier to Surgical Safety?
A systematic review and meta-analysis of over 400,000 patients reveals that while older adults face higher relative risks for nerve injury and hematoma following thyroidectomy, the absolute risk remains low, confirming the procedure’s overa
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