Otorhinolaryngology
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Early Cochlear Implantation Shows Variable but Clinically Relevant Benefits in Children with Single-Sided Deafness: A Western Australian 10‑Year Series
A retrospective 10‑year series from Perth Children’s Hospital reports heterogeneous long‑term outcomes after pediatric cochlear implantation for single‑sided deafness; earlier implantation (within 1 year) was associated with greater likelih
Pre-Fitting Predictors of 2‑Year Hearing Aid Use in 284,175 US Veterans: When Patient Context Matters More Than Audiometry
In 284,175 US veterans, nonmodifiable pre‑fitting factors—health comorbidity, mental status, prior hearing‑aid experience, age, race/ethnicity, and partnership—were independently associated with 2‑year hearing‑aid use persistence, beyond au
Hearing Loss Delays Semantic Prediction When Listening Is Demanding: Two-Stage Prediction Impaired by Cognitive Load
A visual-world eye-tracking study in older adults shows that postlingual hearing loss delays verb-driven semantic prediction—especially under higher listening demand—while simple agent-based prediction is preserved.
Type 2 Diabetes Quadruples Risk of Hearing Loss — Meta-analysis Finds Predominant High-Frequency Impairment and Links to Duration and HbA1c
A PRISMA systematic review and meta-analysis of 17 studies (2019–2024) found type 2 diabetes is associated with a 4.19-fold greater odds of hearing loss, especially at high frequencies; duration >10 years and higher HbA1c amplified risk.
DB-OTO Restores and Sustains Hearing in Otoferlin-Deficient Mice: A Hair-Cell–Targeted Dual-AAV Strategy Advances to Clinical Testing
DB-OTO, a hair-cell-specific dual-AAV gene therapy encoding full-length human otoferlin, achieved dose-dependent and sustained auditory restoration in OTOF-deficient mice, supporting an ongoing Phase I/II pediatric trial.
Epstein-Barr Virus Serology as a Predictor of Persistent Oral HPV Infection in Men: Insights From the Finnish Family HPV Study
A Finnish longitudinal study reveals that elevated Epstein-Barr virus antibody levels are significantly associated with persistent oral HPV infections, highlighting potential viral interplay in oropharyngeal oncogenesis risk.
Evaluating Atezolizumab Maintenance Therapy in High-Risk Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Insights from the IMvoke010 Trial
Atezolizumab maintenance therapy after multimodal definitive treatment failed to improve event-free or overall survival in high-risk LA SCCHN patients in the phase 3 IMvoke010 trial, highlighting challenges in immunotherapy for this setting
DB-OTO Gene Therapy: A Breakthrough Treatment for OTOF-Related Inherited Deafness in Children
Regeneron’s DB-OTO gene therapy shows promising results in restoring natural hearing in children with profound hearing loss caused by OTOF gene mutations, with 75% achieving significant hearing improvement after a single treatment.
Gender Differences in Chronic Rhinosinusitis: Insights into Diagnosis and Biomarkers
This study explores how biological sex influences CRS diagnosis and inflammatory biomarkers, revealing sex-specific patterns that could inform personalized treatment.
Long-Term Outcomes of Oral Implant Rehabilitation in Patients with Disabilities Under General Anesthesia: A 14-Year Cohort Study
This study evaluates the safety, effectiveness, and longevity of implant-supported prostheses in disabled patients treated under general anesthesia over 14 years.
Enhancing Oral Function through Long-Term Rehabilitation in Tongue and Non-Tongue Cancer Patients
This review examines a study on the long-term impact of an oral rehabilitation program on patients with and without tongue cancer, highlighting benefits and clinical implications.
Persistent Olfactory Dysfunction Following SARS-CoV-2 Infection: Insights from the RECOVER Adult Cohort
A large prospective study demonstrates that olfactory dysfunction is prevalent and often clinically unrecognized long after SARS-CoV-2 infection, highlighting the value of formal smell testing in patient care and cognitive risk assessment.
Evaluating Radiologic Extranodal Extension in HPV-Positive Oropharyngeal Cancer: Accuracy, Prognostic Value, and Clinical Implications from a Multinational Real-World Study
This multinational real-world study reveals limited sensitivity and prognostic value of radiologic extranodal extension (iENE) in HPV-positive oropharyngeal cancer, highlighting the enhanced accuracy with combined CT and MRI and the need fo
Imaging-Detected Extranodal Extension as a Predictor of Distant Recurrence in HPV-Positive Oropharyngeal Cancer
Imaging-based extranodal extension (iENE) in HPV-positive oropharyngeal cancer predicts higher rates of distant metastases and decreased progression-free survival, highlighting its prognostic significance and potential role in refining stag
Revising the TNM Classification for HPV-Associated Oropharyngeal Carcinoma: Improving Prognostic Stratification with Imaging-Detected Extranodal Extension
A new clinical TNM staging proposal incorporating imaging-detected extranodal extension (iENE) refines prognostic accuracy in HPV-positive oropharyngeal carcinoma, aiding risk stratification and future treatment strategies.
Artificial Intelligence in Imaging-Based Extranodal Extension Detection: Advancing Prognostication in HPV-Positive Oropharyngeal Cancer
An AI-driven model accurately detects imaging-based extranodal extension in HPV-positive oropharyngeal cancer from CT scans, improving outcome prediction beyond expert radiologist assessments and identifying patients at higher risk of poore
Evaluating Partial versus Whole Laryngeal Radiotherapy in Early-Stage Laryngeal Carcinoma: A Retrospective Cohort Analysis
This study compares partial laryngeal radiotherapy (PLRT) and whole laryngeal radiotherapy (WLRT) in T1-2N0M0/Tis laryngeal carcinoma, demonstrating comparable locoregional control but less acute toxicity with PLRT, though longer follow-up
Unraveling the Link Between Anxiety and Dizziness in Vestibular Schwannoma Patients: Insights From a Retrospective Cohort Study
A recent study reveals that anxiety significantly correlates with increased dizziness severity in patients with vestibular schwannoma, highlighting an underexplored psychological dimension in symptom burden and prompting calls for integrate
High Adherence to Dupilumab in Chronic Rhinosinusitis with Nasal Polyps: Insights from Real-World US Data
Real-world analysis of 3318 US patients with CRSwNP treated with dupilumab demonstrated high persistence and adherence at 12 months, with significant rates of treatment reinitiation after discontinuation, underscoring dupilumab’s sustained
A Single Injection to Regenerate Alveolar Bone: A Breakthrough in Non-Invasive Periodontitis Treatment
A groundbreaking clinical trial demonstrates that dental pulp stem cell injections can safely and effectively regenerate alveolar bone in chronic periodontitis patients, offering a minimally invasive alternative to surgery.
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