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Early administration of Shenfu injection in septic ICU patients did not reduce vasopressor use but was associated with lower mortality and improved microcirculation, warranting further validation.
Emergency departments serve as vital venues for hepatitis C virus screening, particularly for persons experiencing homelessness who exhibit higher HCV prevalence and face healthcare access barriers. Evidence supports nontargeted screening i
This article explores recent outbreaks of Cyclospora and Cryptosporidium infections in the U.S., their transmission, clinical features, diagnosis, treatment, and prevention, highlighting the public health impact and clinical challenges.
A comprehensive single-cell atlas of lung immune cells reveals distinct immune responses in mild versus severe influenza, highlighting neutrophil dysfunction and lymphocyte impairment as key drivers of pathology.
The APS Consortium establishes a large, prospective cohort of critically ill adults with ARDS, pneumonia, and sepsis to enable biologically based phenotyping, leveraging rich clinical data and biospecimens for improved understanding and the
Pregnant and postpartum individuals continue to face higher risks of severe COVID-19 outcomes, including hospitalization and pneumonia, even after the pandemic emergency has ended, emphasizing the need for ongoing vigilance and tailored cli
This article explores the mechanism by which HBV induces liver fibrosis through pyruvate-dependent ROS production and PPARα inhibition, highlighting novel therapeutic targets for chronic hepatitis B management.
A cluster randomized trial in Toronto nursing homes found that on-site multiplex PCR testing improved viral detection and reduced emergency department transfers during respiratory outbreaks, though it did not alter outbreak size or frequenc
This study characterizes neurological complications in adult Ebola survivors over 7 years, demonstrating persistent cognitive and neuropsychiatric deficits despite gradual improvement, underscoring the need for ongoing neurological follow-u
This article reviews updated clinical understanding of Ebola virus disease in pregnancy amid the Democratic Republic of Congo outbreak, highlighting maternal outcomes, risks of vertical transmission, treatment challenges, and the critical n
The DigiSep trial assessed the impact of metagenomic next-generation sequencing (mNGS) on sepsis outcomes. While primary endpoint improvement was not significant, secondary analyses revealed benefits in mechanical ventilation duration, shoc
A large U.S. Veterans Affairs study found no increased 90-day risk of adverse events after same-day COVID-19 and influenza vaccination compared to influenza vaccination alone, supporting the safety of coadministration with updated COVID-19
MARS therapy significantly reduces total plasma piperacillin levels by approximately one-third per session in critically ill liver failure patients, underscoring the need for therapeutic drug monitoring and individualized antibiotic dosing.
A 12-month follow-up of the REAGIR trial found no significant benefit of adjunctive rose bengal photodynamic therapy with green light over sham treatment in improving visual acuity, scar size, or complication rates in infectious keratitis.
This review synthesizes evidence on preS1 antigen and anti-preS1 IgG dynamics in chronic hepatitis B, highlighting their correlations with viral replication, liver inflammation, and functional cure, and elucidates the neutralising potential
A large-scale VSD study found that prenatal vaccination with bivalent prefusion F RSV vaccine is generally safe, showing no increased risk for preterm birth, stillbirth, or small-for-gestational-age births but a slight increase in hypertens
Hantavirus infection in pregnancy is rare but potentially fatal. Obstetricians should suspect it after rodent or travel exposure, recognize rapid respiratory decline, and prioritize supportive critical care because no proven antiviral thera
Prompt oseltamivir prophylaxis covering at least 70% of eligible nursing home residents within 2 days of outbreak detection was associated with fewer hospitalizations, but not lower mortality.
In a real-world target trial emulation, starting oseltamivir prophylaxis within 2 days for at least 70% of eligible nursing home residents was linked to fewer hospitalizations, but not lower short-term mortality.
A large 26-country survey found that post-infection disorders of gut-brain interaction account for 10.5% of DGBI cases and are linked to younger age, male sex, urban living, anxiety, and greater somatic symptom burden.
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