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A nationwide Danish study found that culture-negative infective endocarditis was less common than previously reported, often presented without fever or sepsis, and showed higher embolic risk. PET-CT was especially useful in prosthetic valve
A major global study shows that some people develop lasting gut-brain disorders after acute gastroenteritis, linking infections to chronic digestive and psychological symptoms.
In NA-treated cirrhotic chronic hepatitis B with complete viral suppression, HBsAg seroclearance was linked to lower HCC risk but not lower hepatic decompensation, reinforcing functional cure as a meaningful but incomplete clinical endpoint
In a nationwide Swedish cohort, type 1 diabetes diagnoses rose briefly after SARS-CoV-2 infection and first vaccine dose, but the signal was short-lived, supporting diagnostic acceleration rather than a durable causal effect.
In critically ill ICU patients with confirmed bacterial infections, appropriate empiric antimicrobial therapy was common and independently linked to lower 28-day mortality and more antimicrobial-free days.
In a randomized controlled trial, the STIckER smartphone-based decision aid increased gonorrhea/chlamydia and pharyngeal STI testing in emergency department patients aged 14 to 24 years, while improving decisional clarity, satisfaction, and
A large meta-analysis found JAK-STAT inhibitors slightly increased influenza, bronchitis, and herpes zoster risk, especially in atopic dermatitis, while serious and opportunistic infections were not significantly increased.
A randomized trial found that rapid respiratory point-of-care testing did not reduce same-day antibiotic prescribing in primary care, though it was safe and may help when a virus is detected.
In 1,610 untreated chronic hepatitis D patients, spontaneous HDV suppression was uncommon but increased over time. Diabetes, male sex, and lower baseline HBsAg, HDV RNA, and ALT predicted suppression and fewer liver-related events.
In NTM-positive bronchiectasis, lower airway dysbiosis involving Mycobacterium and oral bacteria is linked to higher NET levels and more severe disease phenotypes, suggesting that the broader airway microbiome may shape inflammation and out
A new SCCM–ESICM Delphi consensus standardizes clinical criteria for refractory septic shock, focusing on persistent hypoperfusion, fluid unresponsiveness, high vasopressor needs, and bedside ultrasound when mixed shock is suspected.
A large prospective cohort suggests that long-term sequelae of congenital CMV after primary maternal infection are confined to first-trimester exposure, with autism spectrum disorder linked to temporal lobe white matter abnormalities.
A large multicenter study links specific bone marrow immune cell patterns to infection risk in multiple myeloma and proposes a clinically relevant immune score that may support minimally invasive monitoring.
A molecular epidemiology study in Durban found that casual community contact, not only household or named contacts, accounted for a substantial share of drug-resistant tuberculosis transmission.
During Boston’s devastating 1955 polio epidemic, Massachusetts General Hospital trainees conducted groundbreaking patient research while providing round-the-clock care in iron lung wards – a striking contrast to trainee roles during C
In HBsAg-positive, anti-HDV-positive patients, combined measurement of HDV RNA and anti-HDV titers distinguished inactive from active disease and tracked interferon response more effectively than either marker alone.
The REPRIEVE trial reveals higher heart failure incidence in people with HIV, particularly among women, Black participants in high-income regions, and those with hypertension or obesity. Traditional risk factors, not HIV-specific markers, w
A prospective cohort study identifies biomarker signatures for host resistance, disease tolerance, and damage in sepsis, revealing associations with mortality and sepsis subtypes.
A randomized clinical trial found that FMT did not significantly decolonize MDROs or reduce AMR genes in GI disease patients, though it modulated gut microbiome composition.
A study reveals CD16+ γδ T cells as key mediators of antibody-dependent cellular cytotoxicity in HBV infection, correlating with reduced viral replication and offering new therapeutic targets.
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