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A comprehensive study identifies key clinical and temporal risk factors associated with severe invasive group A streptococcal disease in children, highlighting increased severity and incidence post-COVID-19 pandemic in the Netherlands.
A Finnish longitudinal study reveals that elevated Epstein-Barr virus antibody levels are significantly associated with persistent oral HPV infections, highlighting potential viral interplay in oropharyngeal oncogenesis risk.
This study explores how early Epstein-Barr virus (EBV) infection and immune responses influence oral human papillomavirus (HPV) infections in children, revealing the interplay between EBV serology, paternal education, and oral HPV acquisiti
This study links EBV seropositivity to immune dysregulation and increased mortality in pediatric sepsis, highlighting potential pathways for targeted therapies.
This study evaluates clinical testing trends for COVID-19, influenza, and RSV among hospitalized children from 2016 to 2024, revealing shifts in testing frequency and identifying factors influencing test utilization.
Comparative effectiveness evidence from multicenter pediatric emergency departments demonstrates that targeted and universally offered gonorrhea and chlamydia screening increase detection rates versus usual care, highlighting the need for i
This article reviews recent studies on EBV transmission in pediatric kidney transplants, highlighting risk factors, monitoring strategies, and implications for reducing posttransplant lymphoproliferative disorder (PTLD).
This study examines how pandemic-related nonpharmaceutical interventions affected immunity development to Streptococcus pyogenes and common respiratory viruses in children aged 0-4 years, offering insights into rising invasive infections.
A European study reveals that COVID-19 nonpharmaceutical interventions led to reduced immunity against S pyogenes and RSV in children aged 3-4, potentially explaining the recent spike in severe infections.
This study evaluates targeted indoor residual spraying’s effectiveness against Aedes-borne diseases and highlights its limitations despite entomologic success.
A large randomized trial in Mali demonstrated that mass azithromycin administration to infants aged 1–11 months did not reduce mortality compared to placebo, challenging previous findings in sub-Saharan Africa.
Systematic review evidence supports accelerated epigenetic aging in people living with HIV compared to uninfected individuals, highlighting the need for further research considering antiretroviral therapy and confounding factors.
Tomatine, a natural compound incorporated into mRNA vaccine nanocarriers, significantly enhances antigen expression and innate immune activation, boosting adaptive immunity against tumors and SARS-CoV-2, underscoring its potential as a vers
This study elucidates drug resistance patterns and genotype-phenotype correlations in multidrug-resistant Mycobacterium tuberculosis strains from Hainan Island, China, revealing implications for tailored MIC-based therapies.
A genomic epidemiological study reveals that mixed infections and heteroresistance are prevalent among multidrug-resistant tuberculosis cases in Shanghai, complicating diagnosis and treatment.
Immune non-response despite ART in people with HIV significantly increases risk of both AIDS-defining and non-AIDS-defining comorbidities, underscoring the need for enhanced risk assessment beyond CD4+ T-cell counts.
This study reveals that over 80% of tuberculosis cases among South African household contacts are asymptomatic and often missed by symptom and chest X-ray screening, highlighting the need for improved diagnostic strategies to detect subclin
A randomized trial found outpatient treatment of young infants with a single low-mortality-risk sign of possible serious bacterial infection is non-inferior to inpatient care, with lower mortality rates and comparable safety.
This multicountry trial demonstrates that early switch from injectable to oral antibiotics with early discharge in young infants with moderate-risk serious bacterial infections is safe and effective, with potential to optimize healthcare re
This review synthesizes motivations, facilitators, and barriers of donation-based interventions in HIV/STI research, revealing key factors that enhance access to services through prosocial behaviors in diverse global settings.
