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A randomized clinical trial in South Australian long-term care facilities found germicidal UV light appliances did not significantly reduce acute respiratory infection rates per cycle but modestly lowered total infections over time, suggest
A recent multicenter trial demonstrates that a single dose of benzathine penicillin G is noninferior to three doses in treating early syphilis, including patients with HIV, simplifying management and reducing adverse effects.
This longitudinal single-cell multiomics study delineates the evolving immune landscape in HBV-ACLF, identifying key immune cell subsets and signaling pathways that drive disease progression and highlight potential therapeutic targets for p
SCG101, an HBV-specific T-cell receptor T-cell therapy, demonstrates significant antiviral and antitumour efficacy with a manageable safety profile in patients with advanced HBV-related hepatocellular carcinoma refractory to prior treatment
This phase 2 trial demonstrates that azelastine nasal spray reduces SARS-CoV-2 infections and symptomatic respiratory illnesses in a healthy, vaccinated adult population, suggesting its potential as a safe, scalable prophylactic measure aga
A large multicenter study demonstrates that a single dose of RSV vaccine reduces hospitalization risk by 58% among adults aged 60+, with lower effectiveness in immunocompromised and cardiovascular patients.
A recent study shows that over 80% of patients allergic to amoxicillin tolerate piperacillin-tazobactam, though about 18% experience cross-reactivity, highlighting the need for careful allergy testing before use.
A multicountry study across Asia demonstrates soluble TREM1’s superior accuracy over traditional clinical signs in predicting severe febrile illness in children, potentially transforming triage in resource-limited settings.
Long COVID patients exhibit distinct mitochondrial bioenergetic impairments, with altered ATP synthase function correlating with clinical symptoms and quality of life, implicating mitochondrial dysfunction in its pathogenesis.
A 25-year-old woman with recurrent urinary tract infections was diagnosed with unilateral renal agenesis, highlighting the importance of imaging in persistent urinary symptoms.
Iterum Therapeutics has launched Orlynvah, the first oral penem antibiotic approved in the US for uncomplicated urinary tract infections, addressing growing antibiotic resistance.
Kidney-transplant recipients on long-term kidney replacement therapy demonstrate significant reductions in COVID-19-related hospitalizations and mortality following three or more vaccine doses, supporting booster vaccinations in this vulner
Recent rhinovirus infection may nearly halve COVID-19 risk and reduce viral load by triggering airway antiviral gene expression, partially explaining children’s milder COVID-19 outcomes.
A recent Irish study reveals that 6 in 10 healthcare workers with respiratory symptoms test for COVID-19, while vaccination coverage remains low, highlighting ongoing risks and the need for enhanced infection control and vaccination strateg
Observational data from the RECOVER Initiative suggest that SARS-CoV-2 reinfection raises the risk of long COVID by 35% relative to single infections, with more recent vaccination potentially mitigating this risk.
COVID-19 accelerates vascular aging by approximately 5 years, disproportionately affecting women, with vaccination conferring protection primarily in females, highlighting sex-specific immunological responses and long-term vascular risks.
The Stratus variant, known as XFG, now dominates COVID-19 cases in the U.S., complicating recovery efforts amidst rising infections and changing vaccine guidance.
The American Academy of Pediatrics recommends COVID-19 vaccination for all young children aged 6-23 months, diverging from current CDC policies that advise shared decision-making for healthy children. This review analyzes epidemiologic data
Sulopenem demonstrates noninferior efficacy to amoxicillin/clavulanate in treating uncomplicated UTI with a higher rate of mild adverse events, amidst rising antimicrobial resistance challenges.
A phase 4 randomized trial demonstrates that combining rabies monoclonal antibody with vaccine in category 3 exposures is safe, immunogenic, and effective in preventing rabies up to one year post-exposure.
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