250 articles · 20 / page
A decision analytical model reveals that while active surveillance offers short-term quality-of-life benefits, standard esophagectomy provides superior 5-year survival and quality-adjusted life-years (QALYs) for esophageal cancer patients a
A large-scale retrospective study in Ontario indicates that solid-organ transplant recipients, particularly kidney transplant patients, experience significantly better outcomes for emergency general surgery conditions when treated at specia
A comprehensive analysis of North American data reveals a significant resurgence in the Ross procedure for young adults, while highlighting a stark correlation between center volume and operative mortality, suggesting a critical threshold o
A randomized controlled trial demonstrates that a 3-month standardized neck and orofacial rehabilitation program significantly improves swallowing-related quality of life and functional recovery in post-thyroidectomy patients, effectively a
This review synthesizes recent PubMed-indexed evidence on autologous blood-derived therapies, such as PRP and PRF, highlighting their role in accelerating wound healing through growth factor signaling and cellular recruitment.
The ADMIRE CD II Phase 3 trial failed to show a significant benefit of darvadstrocel over placebo for complex perianal fistulas in Crohn’s disease, primarily due to an unexpectedly high remission rate in the placebo-controlled surgica
Researchers have developed the Liver Immune Frailty Index (LIFI), a biomarker-based tool using fractalkine and MMP3 to predict post-liver transplant mortality. With a C-statistic of 0.83, LIFI identifies high-risk candidates, potentially tr
A study of over 6,000 patient interactions reveals that higher annual trauma volumes per EMS clinician are significantly associated with reduced 6-hour and in-hospital mortality, emphasizing the need for volume-based staffing and training.
A multi-center study demonstrates that preoperative ctDNA detection significantly outperforms traditional clinical criteria in predicting nodal upstaging and survival outcomes for patients with clinical stage I/II ESCC, potentially redefini
The 5-year follow-up of the LASSO randomized clinical trial demonstrates that while laparoscopic adhesiolysis offers short-term recovery benefits, it provides no significant long-term advantage over open surgery regarding SBO recurrence, in
A multicenter randomized clinical trial demonstrates that selective calcium supplementation based on early postoperative PTH levels is as effective as routine prophylaxis in preventing hypocalcemia after total thyroidectomy, offering a stra
A population-based study in England reveals that correcting socioeconomic and clinical inequalities in the use of minimally invasive surgery for colon cancer significantly reduces hospital stays and 1-year mortality, highlighting a critical
A post-hoc analysis of the nationwide PORSCH trial reveals that algorithm-based care for early recognition and management of postoperative complications significantly improves long-term overall survival in patients undergoing pancreatic res
A JAMA study demonstrates that Rapid Ultraoxygenated Recovery (REUP) enables successful DCD heart transplantation without preimplant reanimation, achieving 96% survival despite extended ischemic times and older donors, potentially offering
A systematic review and meta-analysis of over 400,000 patients reveals that while older adults face higher relative risks for nerve injury and hematoma following thyroidectomy, the absolute risk remains low, confirming the procedure’s
The DALI cohort study reveals that while current DOAC interruption protocols are generally effective, 13.1% of apixaban users maintain levels ≥30 ng/mL before surgery. However, these residual levels did not correlate with increased surgical
A large-scale study of Swiss surgical patients reveals that nearly 20% of those experiencing major complications die in-hospital. Critical variations between institutions suggest that over 1,000 deaths could be avoided through improved orga
A national Swiss study reveals that 1 in 5 surgical patients experiencing major complications die, with nearly 15% of these deaths linked to institutional performance gaps rather than patient risk factors.
This cohort study demonstrates that postoperative sleep architecture is differentially disrupted based on surgical risk. High-risk procedures cause prolonged deficits in REM and deep sleep, which are associated with increased complications,
The LEGenD-1 trial demonstrates that intramuscular HGF gene therapy (AMG0001) significantly reduces healing time for neuroischemic ulcers in patients with moderate chronic limb-threatening ischemia, offering a potential nonsurgical therapeu
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