General Surgery
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Rizedisben Enhances Nerve Visualization in Minimally Invasive Prostate Surgery: Insights from a Phase 1 Dose-Escalation Trial
This phase 1 trial identifies 3.0 mg/kg as the optimal safe and effective dose of rizedisben, a novel myelin-binding fluorophore, enhancing sustained intraoperative nerve fluorescence during robot-assisted laparoscopic radical prostatectomy
Preoperative Cardiovascular Risk Does Not Alter Outcomes of Renin-Angiotensin System Inhibitor Use Before Major Noncardiac Surgery: Insights from a Secondary Analysis of the STOP-or-NOT Trial
A secondary analysis of the STOP-or-NOT trial shows that preoperative cardiovascular risk stratification does not impact postoperative outcomes related to continuing or discontinuing renin-angiotensin system inhibitors before major noncardi
Fiber-Based Near-Infrared Autofluorescence Enhances Parathyroid Identification in Endocrine Neck Surgery Without Reducing Hypoparathyroidism Risk
This multicenter randomized clinical trial demonstrates that fiber-based near-infrared autofluorescence (NIRAF) enhances intraoperative parathyroid gland identification during thyroidectomy and bilateral parathyroidectomy without increasing
Open Anterior Mesh Repair Versus Modified Technique for Groin Hernia in Women: Insights from a Ugandan Randomized Trial
A randomized clinical trial in Uganda compared standard open anterior mesh repair with a modified technique addressing femoral hernias, demonstrating both methods as safe and effective options for women’s groin hernia repair in low-resource
Chemoradiotherapy After Induction Chemotherapy: Enhancing R0 Resection Rates in Unresectable Pancreatic Cancer—Insights from the CONKO-007 Trial
The CONKO-007 trial reveals that adding chemoradiotherapy after induction chemotherapy increases margin-negative (R0) resections in surgically treated unresectable pancreatic cancer but does not improve overall survival.
Surgical Management of Left-Sided Infective Endocarditis: Insights from the Nationwide NIDUS Registry
A nationwide Danish study reveals that while 40% of left-sided infective endocarditis patients have surgical indications, only half undergo surgery. Those receiving surgery are younger, less comorbid, and show improved survival, underscorin
Ivabradine Fails to Reduce Myocardial Injury After Noncardiac Surgery: Insights from a Large RCT
A large randomized trial shows that ivabradine, despite effectively lowering heart rate during surgery, does not reduce myocardial injury after noncardiac surgery, highlighting the complexity of perioperative cardiac risk management.
Real-World Insights into Clinical Presentation and Surgical Outcomes of Mitral Regurgitation from the MITRACURE Registry
The MITRACURE international registry reveals that mitral valve surgery patients often present late in disease progression with advanced symptoms, showing modest repair rates and notable in-hospital mortality, underscoring the need for earli
Reducing Infection Risk in Repeat CIED Surgery with Iodine-Impregnated Drapes: Insights from a Randomized Clinical Trial
A randomized trial demonstrates that iodine-impregnated drapes significantly reduce pocket contamination and cardiac implantable electronic device infections in repeat surgeries, offering a simple, cost-effective prophylactic intervention.
Preoperative Anxiety as a Key Predictor of Postoperative Delirium: Insights from a Year-Long Cohort Study
A prospective study reveals that nearly 20% of surgical patients experience postoperative delirium in the PACU, with elevated preoperative anxiety significantly increasing this risk. Implementation of a brain health care bundle improves man
The Hidden Danger of a Beach Injury: Understanding Vibrio vulnificus Infection
A six-year-old boy nearly lost his leg after stepping on a dead fish infected with Vibrio vulnificus. This article explores the bacteria’s risks, prevention, symptoms, and expert advice for safe seaside outings.
Electroacupuncture Significantly Shortens Postoperative Ileus After Laparoscopic Gastrectomy for Gastric Cancer: Insights from a Multicenter Randomized Trial
This multicenter randomized trial demonstrates that electroacupuncture reduces postoperative ileus duration and accelerates gastrointestinal recovery after laparoscopic gastrectomy for gastric cancer, outperforming sham and standard care.
SADI-S vs RYGB for Obesity: Superior Weight Loss and Comparable Safety at 2 Years from the French SADISLEEVE Trial
A French multicentre trial showed single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) achieved superior weight loss compared to Roux-en-Y gastric bypass (RYGB) at 2 years, with similar safety profiles.
Predictive Factors for Diabetes Outcomes One Year After Total Pancreatectomy with Islet Autotransplantation: Insights from a Large Multicenter Study
This multicenter study identifies key predictors of diabetes outcomes one year after total pancreatectomy with islet autotransplantation, highlighting the importance of preoperative glycemic control and age in achieving insulin independence
Reevaluating the Necessity of Nasogastric Tubes After Oesophagectomy: Insights from a Nordic Multicentre Trial
A comprehensive Nordic trial reveals that postoperative nasogastric tube removal may increase anastomotic leak risk after oesophagectomy, suggesting continued use of NG tubes for patient safety.
Clinical Presentation, Management, and Outcomes of 11,132 Liposarcoma Patients: Insights from the NETSARC+ Registry
The NETSARC+ registry study comprehensively characterizes liposarcoma histotypes, revealing diverse clinical presentations, management strategies, and prognoses, with dedifferentiated liposarcoma having the poorest survival and age-sex spec
Association of Hysterectomy With Hypertension Incidence in Korean Women: Insights from a Nationwide Cohort Study
This nationwide Korean cohort study found that hysterectomy is associated with a modestly increased risk of developing hypertension in women aged 40 to 59 years, particularly in those with elevated post-surgical hemoglobin levels and after
Perioperative Nitric Oxide Conditioning in Cardiac Surgery: A Paradigm Shift for Protecting Renal Function in CKD Patients (DEFENDER Trial Review)
Perioperative nitric oxide administration in CKD patients undergoing cardiac surgery significantly reduces acute kidney injury incidence and preserves renal function, while demonstrating safety and additional benefits against postoperative
Impact of Red Blood Cell Transfusion Strategies on Outcomes in Acute Myocardial Infarction Patients Undergoing Revascularization: Insights from the MINT Trial
This prespecified analysis of the MINT trial evaluates how liberal versus restrictive red blood cell transfusion strategies affect 30-day outcomes in acute MI patients, focusing on those undergoing revascularization, revealing nuanced risk
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