Latest news
5033 articles · 20 / page
Can Prehabilitation Reduce Complications After Spinal Fusion in Older Adults? What a New Randomized Trial Suggests
A multicenter randomized trial found that 4-week multimodal prehabilitation added to ERAS reduced 90-day complications after spinal fusion in adults aged 75 years or older.
Allogeneic Stem Cell Transplantation After 70: Japanese Registry Data Define Who May Benefit Most
A Japanese registry study of 929 patients aged 70+ identified six predictors of worse survival after allo-HSCT and created a simple score that sharply stratified 2-year overall survival from 57.1% to 2.5%.
BRAF Mutations in AML: Rare, Biologically Distinct, and Linked to Poor Outcomes
BRAF mutations occur in about 1% of AML and are usually non-V600 variants enriched in myelodysplasia-related disease. This cohort study found poor survival and suggested that current therapies, including venetoclax-based regimens, remain in
Complement Activation May Define a Refractory Subset of Adult ITP
Complement deposition on platelets identifies a biologically distinct subset of adult ITP associated with higher platelet turnover and more first-line treatment refractoriness.
Why One Sleep Study May Not Tell the Whole Story: Night-to-Night Variability, AHI Definitions, and OSA Reclassification
A recent Chest study shows that PSG metrics vary unevenly across nights, and AHI scored with 4% desaturation is less stable than AHI 3%/arousal. Hypoxic burden was more reproducible and may better reflect true OSA severity.
Early Neutrophil and Persistent Eosinophil Gene Signatures in Childhood Asthma
A longitudinal blood gene-expression study in children found an early neutrophil-driven immune pattern at age 1, followed by a persistent eosinophilic signature from 4.5 to 10.5 years in those who later developed asthma.
Ripasudil After DSO in Fuchs Endothelial Corneal Dystrophy: A Randomized Trial Signals a New Path to Corneal Recovery
A phase 2 randomized trial found that topical ripasudil after DSO improved endothelial cell density, sped edema clearance, and reduced rescue therapy in FECD, especially with QID dosing.
Retinal Microvascular Clues to Alzheimer Disease: What Swept-Source OCT Angiography Reveals About Neurovascular Dysfunction
SS-OCTA identified retinal and choriocapillaris microvascular changes associated with cognitive status in Alzheimer disease, including thinner GCC in dementia and a biphasic CCFD pattern, suggesting a promising noninvasive biomarker platfor
Calm in the Clinic? Digital Mindfulness Shows Promise for Anxiety and Depression in Non-infectious Uveitis
A randomized trial found that an 8-week digital mindfulness app improved anxiety, depression, and stress in adults with non-infectious uveitis, but did not significantly change vision-related quality of life.
MDASI-HN Symptom Profiling for Early Risk Stratification of Hypoglossal Neuropathy in Oropharyngeal Cancer Survivors
This study found that patient-reported speech/voice and related head-and-neck symptoms can help predict hypoglossal neuropathy risk after oropharyngeal cancer treatment, supporting earlier surveillance with the MDASI-HN-NERVE score.
Low-Yield or High-Value? Preoperative Cardiac Workup in Children With Very Severe OSA
Preoperative cardiac testing in children with very severe OSA had low diagnostic yield and rarely changed management. Risk appeared highest in obese adolescents with AHI >50 events/hour.
Postoperative Outcomes of Morel-Lavallée Injuries and Predictive Factors for Wound Complications
A multicenter trauma study found that 20.1% of surgically treated Morel-Lavallée lesions developed wound complications. Pedestrian-versus-vehicle injury was the only independent predictor of postoperative problems.
Immune Checkpoint Inhibitors Deliver Durable Responses in MSI-H Gastroesophageal Adenocarcinoma
MSI-H/dMMR gastroesophageal adenocarcinoma showed high response rates to immune checkpoint inhibitors, including durable complete responses in locoregional disease that may support carefully selected nonoperative management.
Checkpoint Blockade Delivers Deep, Durable Responses in MSI-H Gastroesophageal Adenocarcinoma
This single-center cohort found high and durable checkpoint inhibitor responses in dMMR/MSI-H gastroesophageal adenocarcinoma, including complete responses in locoregional disease that may support carefully selected nonoperative management.
GLP-1 Receptor Agonists May Outperform Bariatric Surgery for Breast Cancer Outcomes in Obese Postmenopausal Women
In a large TriNetX study, GLP-1 receptor agonists were associated with better overall survival and lower locoregional recurrence than bariatric surgery alone in obese postmenopausal women with stage 0-III breast cancer.
GLP-1 Receptor Agonists May Outperform Bariatric Surgery in Obese Postmenopausal Breast Cancer Patients, Study Suggests
A large real-world study found GLP-1 receptor agonists were associated with better survival and lower locoregional recurrence than bariatric surgery in postmenopausal women with obesity and breast cancer.
Prehabilitation During Neoadjuvant Chemotherapy May Improve Surgery Eligibility and Chemotherapy Delivery in Advanced Ovarian Cancer
A matched-cohort study found that multimodal prehabilitation during neoadjuvant chemotherapy improved chemotherapy delivery and increased the chance of interval debulking surgery in advanced ovarian cancer, with the strongest benefits seen
When the Prenatal Ultrasound “Level” Does Not Match the Neurologic Reality: Mapping Anatomical-Motor Discordance in Open Spinal Dysraphism
In 187 fetuses with open spinal dysraphism, prenatal motor level was more caudal than the anatomical level in 85% of cases, with larger gaps in myeloschisis and higher lesions.
Why the Spinal Lesion Level on Prenatal Ultrasound Often Does Not Match Fetal Motor Function
Prenatal ultrasound in open spinal dysraphism often underestimates functional level: in 85% of fetuses, motor level was more caudal than anatomy. Lesion type and height influenced the gap, with implications for counseling and fetal care pla
From Symptoms to Preferences: Q-Methodology Maps What Women With Chronic Pelvic Pain Want From Treatment
A Q-methodology study translated chronic pelvic pain experiences into five patient preference profiles to better align counseling and treatment selection with what matters most to patients.
Browse by specialty
Open language-specific specialty feeds and department pages.