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Over half of pediatric sepsis hospitalizations are preceded by healthcare visits within 7 days, highlighting a critical window for early sepsis recognition and intervention in children.
Extremely high NT-proBNP levels in hospitalized patients often indicate infection rather than heart failure, with a high mortality risk; interpretation requires comprehensive clinical context.
This review synthesizes perspectives from key stakeholders on AI integration in home care, highlighting benefits, risks, and governance challenges to inform equitable, sustainable AI adoption.
This qualitative study explores how internal medicine clinicians develop skills in discussing goals of care, revealing a progression from basic understanding to advanced, integrated communication approaches, and underscores the need for str
A concise, clinician-friendly summary of the 2026 VA/DoD guideline for treating tobacco and nicotine use, focusing on evidence-based pharmacotherapy, counseling, and new recommendations for electronic and smokeless products.
A comprehensive single-cell RNA sequencing study of large B cell lymphomas reveals five malignant B cell archetypes, with one subtype predictive of poor treatment response and survival, paving the way for precision therapy in LBCL.
Measurable residual disease (MRD) testing offers critical insights to tailor allogeneic hematopoietic cell transplantation in adults with acute myeloid leukemia, optimizing patient selection, conditioning intensity, and relapse surveillance
Soluble BCMA levels in newly diagnosed multiple myeloma patients reveal distinct tumor phenotypes and predict prognosis more strongly than tumor volume, enabling improved risk stratification and clinical decision-making.
An explainable machine learning model identifies bariatric surgery candidates at risk for obesity hypoventilation syndrome using seven accessible clinical variables, enhancing early diagnosis and perioperative risk management.
Monitoring chronic pulmonary aspergillosis progression using time-normalized anti-Aspergillus IgG kinetics shows promise for early detection of disease worsening, supporting timely clinical reassessment alongside imaging and microbiology.
This analysis of U.S. CF Foundation registry data reveals that inhaled antibiotics confer lung function benefits primarily in chronic Pseudomonas aeruginosa infections, but their treatment benefit has declined with CFTR modulator use. Risks
Metered-dose liquid nitrogen cryospray significantly improves quality of life and reduces severe exacerbations in COPD patients with chronic bronchitis, with a favorable safety profile demonstrated in a recent sham-controlled trial.
SHARP registry data reveal that biologic therapies improve clinical outcomes equally in severe asthma patients irrespective of smoking status, challenging prevailing prescribing hesitancy and advocating inclusive treatment approaches.
A retrospective cohort study demonstrates that a tailored, stepwise multimodal approach effectively controls conjunctival melanocytic lesions with reduced recurrence and metastasis risks, guided by lesion grade and clinical features.
This retrospective study found no significant seasonal variation in pediatric epistaxis referrals and management, challenging the common belief that nosebleeds peak in dry, winter months and suggesting year-round patient counseling.
This retrospective study highlights the risk of airway complications and mortality in laryngeal chondrosarcoma patients managed with function-preserving surgery, emphasizing the need for vigilant surveillance and tailored treatments.
This study evaluates the development, implementation, and performance of EHR-integrated synoptic operative reporting templates in head and neck cancer surgery, highlighting improved documentation quality and variable adherence.
In a large Dutch cohort, 90% of patients with Barrett’s esophagus-related dysplasia or cancer had no prior endoscopic surveillance, highlighting a critical gap in early detection and the need for evidence-based screening strategies.
This multinational study reveals that specific gut microbiome profiles significantly correlate with 90-day hospitalisation risk in cirrhosis, enhancing prognostic accuracy beyond clinical features alone.
This study integrates multi-omics data to characterize steatohepatitic hepatocellular carcinoma (SH-HCC), establishing robust diagnostic models and identifying FABP4 as a promising therapeutic target, with implications for personalized mana
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