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A Standardized Emergency Department Guideline for Nebulized Tranexamic Acid Was Linked to Fewer Operating Room Returns After Post-Tonsillectomy Hemorrhage
A hospital clinical care guideline enabled rapid uptake of nebulized tranexamic acid for eligible post-tonsillectomy hemorrhage and was associated with a marked reduction in operative control of bleeding.
A Pain-Predominant Dry Eye Phenotype Emerges: Severe Symptoms, Few Ocular Signs, and Strong Links to Migraine and Psychiatric Disease
A 2026 Ophthalmology report identified a pain-predominant dry eye phenotype in 6.9% of patients, marked by high symptom burden, minimal surface signs, and enrichment for migraine and psychiatric comorbidity.
Internet-Based CBT for Tinnitus Shows Durable Benefit Up to 6 Years, but Long-Term Interpretation Requires Caution
A 6-year follow-up of guided internet-based CBT for tinnitus found sustained reductions in tinnitus distress, with smaller persistent gains in mood and sleep, despite substantial attrition and the absence of a long-term control group.
Internet-Based CBT for Tinnitus Shows Durable Benefit Up to 6 Years, With Sustained Reduction in Distress but More Modest Auditory Gains
A 6-year follow-up study suggests guided internet-based CBT for tinnitus can produce durable reductions in tinnitus distress, with sustained but smaller benefits for mood, insomnia, and life satisfaction.
A Post-Tonsillectomy Hemorrhage Guideline With Nebulized Tranexamic Acid Was Linked to Fewer Returns to the Operating Room
A quality-improvement guideline standardizing nebulized tranexamic acid for post-tonsillectomy hemorrhage achieved high protocol adherence and was associated with a marked reduction in operative hemorrhage control.
Relaxing Diaphragmatic Incisions May Improve Symptom Outcomes in Difficult Hiatal Hernia Repair, but Morphologic Durability Remains Unproven
In complex redo and giant hiatal hernia repair, lateral diaphragmatic relaxing incisions were feasible and associated with favorable patient-reported symptom control at 24 months, although objective recurrence data are still lacking.
Role of Relaxing Lateral Incisions as an Add-On to Difficult Hiatal Repair in Redo and Giant Hernia Cases
A modified diaphragmatic relaxing incision technique may reduce tension during difficult redo and giant hiatal hernia repairs, with most patients reporting improved reflux symptoms and low postoperative symptom burden.
Onlay Mesh Was Linked to Lower Reoperation and Bowel Obstruction Risk Than Retromuscular or IPOM Repair in Primary Ventral Hernia Surgery
A nationwide Danish cohort found lower risks of reoperation for recurrence and bowel obstruction after onlay mesh placement compared with retromuscular repair and IPOM in elective primary ventral hernia repair.
Pancreatic Cancer Risk During IPMN Surveillance Is About 10-Fold Higher Than in the General Population
A SEER-matched analysis found that patients undergoing IPMN surveillance have a markedly elevated malignancy risk, with substantial heterogeneity by duct dilation, obesity, age, and cyst features.
Pancreatic Cancer Risk During IPMN Surveillance: A SEER-Based Comparison
A SEER-based study found IPMN surveillance patients have about 10 times higher pancreatic cancer risk than the general population, with highest risk in those with main duct dilation or obesity.
More Than Half of Patients With Atypical Endometrial Hyperplasia Had Occult Cancer at Hysterectomy in a Minority-Enriched Urban Cohort
A single-center retrospective study found unexpectedly high rates of concurrent endometrial carcinoma and Mayo-criteria risk features among patients with atypical endometrial hyperplasia in a predominantly racial and ethnic minority populat
Predictors of Concurrent Endometrial Carcinoma in Minority Populations with Atypical Hyperplasia: A Synthesis of Clinical, Molecular, and Social Evidence
This review synthesizes recent evidence on concurrent endometrial carcinoma risk in atypical hyperplasia, highlighting significant disparities in minority populations, the protective role of adenomyosis, and the emergence of GLP-1 receptor
Minimal Access vs. Open Hysterectomy in Endometrial Cancer: A Critical Synthesis of Surgical and Survival Outcomes
This review synthesizes findings from a large-scale cohort study comparing laparoscopic and abdominal hysterectomy, highlighting significant surgical advantages for laparoscopy despite complex survival data.
Maternal-Fetal Alloimmunity and Gestational Outcomes: Assessing Anti-HLA Antibodies as a Risk Factor for Fetal Growth Restriction
This review explores the association between maternal anti-HLA antibodies and fetal growth restriction (FGR), synthesizing evidence that suggests an alloimmune mechanism may contribute to placental dysfunction and restricted fetal developme
Postmarketing Data Link Fezolinetant Primarily to Early Transaminase Elevations Rather Than Overt Liver Injury
FAERS postmarketing data suggest fezolinetant is associated with an early hepatic adverse event reporting signal, driven mainly by liver enzyme elevations rather than consistent severe clinical liver injury.
Targeted Galectin-3 Inhibition for Portal Hypertension: Insights from the NAVIGATE Trial and Belapectin’s Role in MASH Cirrhosis
This review synthesizes clinical evidence for Belapectin, a Galectin-3 inhibitor, focusing on its ability to prevent esophageal varices in patients with MASH cirrhosis and portal hypertension as demonstrated in the NAVIGATE trial.
Galectin-3 Inhibition in MASH Cirrhosis: Synthesizing Evidence from the NAVIGATE Trial and Emerging Therapeutics
This review synthesizes clinical evidence for belapectin in MASH cirrhosis, focusing on its efficacy in preventing esophageal varices as demonstrated in the NAVIGATE trial and early phase 2b data.
Belapectin for the Prevention of Esophageal Varices in MASH Cirrhosis: Insights from the NAVIGATE Phase 2b Trial
This review synthesizes clinical evidence on belapectin, a galectin-3 inhibitor, highlighting its potential to reduce the incidence of esophageal varices in patients with MASH-related cirrhosis and portal hypertension, particularly at the 2
Exercise May Be a Disease-Modifying Strategy in Chronic Pancreatitis
A new multimodal study links regular physical activity to lower chronic pancreatitis risk and identifies muscle-derived extracellular vesicles as a plausible mechanism limiting pancreatic inflammation, fibrosis, and ferroptosis.
Therapeutic Mobilization: How Physical Activity Reprograms the Pancreatic Immune Microenvironment to Combat Chronic Pancreatitis
This review synthesizes recent evidence from the UK Biobank and molecular studies demonstrating that physical activity, particularly resistance exercise, restrains chronic pancreatitis by delivering muscle-derived extracellular vesicles tha
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