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Beyond Binary: A 4-Stage Risk Stratification Tool Transforms Cochlear Implant Candidacy Assessment
Researchers developed a novel 4-level classification system using routine audiometric data to estimate cochlear implant candidacy likelihood, moving beyond traditional binary screening approaches to support personalized shared decision-maki
Celecoxib Cuts Opioid Use Nearly in Half After Throat Surgery—Without Increasing Pain
A retrospective cohort study of 80 patients undergoing tonsillectomy, adenoidectomy, or uvulopalatopharyngoplasty found that adding celecoxib to multimodal analgesia reduced mean opioid consumption by 44%, while maintaining comparable pain
Conversion from Minimally Invasive to Open Pancreatectomy Carries Higher Complication Risk, Study Finds
A large retrospective analysis of over 11,000 patients reveals that conversion to open surgery during minimally invasive left-sided pancreatectomy is independently associated with increased postoperative complications. The findings undersco
Strengthening the Frail: Multimodal Prehabilitation and Clinical Resilience in Geriatric Gastric Cancer Surgery
This review synthesizes evidence from the GISSG+2201 trial and related studies, demonstrating that supervised multimodal prehabilitation significantly reduces postoperative complications and enhances functional recovery in older, frail pati
Volume Matters: New Study Defines Minimum Annual Caseload for Safer Fenestrated and Branched Aortic Repair
Researchers identify critical hospital and surgeon volume thresholds for fenestrated/branched endovascular aortic repair (F/BEVAR). Patients treated at low-volume centers face up to 51% higher 30-day mortality, with inflection points at 9 h
Anti-Angiogenic Profile at Term Signals Faster Labour Onset in Low-Risk Pregnancies, Study Finds
Prospective cohort data from Switzerland reveal that elevated sFlt-1/PlGF ratios at term correlate with shorter time to spontaneous delivery in low-risk pregnancies, while PlGF declines and sFlt-1 rises from term to post-term. These finding
Stool Biospecimen Collection in Gynecologic Oncology: New Study Demonstrates Feasibility and Identifies Provider Engagement as Key Driver
A prospective study evaluating at-home stool collection for gut microbiome research in gynecologic oncology demonstrates implementation feasibility with 61% patient enrollment. Provider engagement emerged as the strongest predictor of parti
Timing Delivery for Large-for-Gestational-Age Fetuses: The Case for Earlier Induction
A large cohort study of over 84,000 pregnancies reveals that induction at 38-39 weeks for large-for-gestational-age fetuses achieves comparable cesarean risk to spontaneous labor at 40 weeks, while avoiding the steep rise in complications b
The Rising Burden of Anemia in Pregnancy: Epidemiological Trends, Clinical Impact, and Evolving Management Strategies
This review synthesizes recent evidence on pregnancy-related anemia, highlighting a 25.6% US prevalence, the clinical significance of iron deficiency without anemia (IDWA), and the critical impact on maternal-fetal outcomes and cardiovascul
Validating the Virtual Biopsy: Noninvasive Surrogate Endpoints for Disease Progression and Treatment Efficacy in MASH
This review synthesizes the evolving landscape of noninvasive tests (NITs) in MASH, detailing their role as surrogate endpoints for adverse outcomes and therapeutic response based on recent clinical trials and meta-analyses.
Novel Fusion Model Combines Hypoxia and Immune Signatures to Predict Survival in HCC Patients Undergoing TACE Therapy
A groundbreaking multicentre study develops a clinical-radiologic model integrating hypoxia and immune phenotype signatures to accurately predict prognosis in hepatocellular carcinoma patients treated with transarterial chemoembolisation, p
Beyond Pathology: DNA/RNA Sequencing Achieves Near-Double Sensitivity in Detecting Bile Duct Cancer
A landmark six-year study involving over 2,000 patients at 28 institutions demonstrates that next-generation sequencing of ERCP-obtained specimens achieves 82% sensitivity for neoplastic bile duct strictures, nearly doubling traditional pat
Decoding Dementia in Lewy Body Disease: The Interplay of Quantitative Pathology, APOE Genotype, and Disease Heterogeneity
Recent advances in digital pathology and machine learning reveal that APOE ε4 promotes proteinopathy and modifies dementia thresholds, while multi-modal trajectories suggest distinct pathways for disease progression in Lewy body disease.
Eptinezumab Combined with Patient Education for Chronic Migraine and Medication-Overuse Headache: Insights from the RESOLUTION Trial
The Phase 4 RESOLUTION trial demonstrates that eptinezumab 100 mg IV, combined with standardized patient education, significantly reduces migraine frequency and acute medication reliance in adults with comorbid chronic migraine and medicati
Iatrogenic Alzheimer Pathology Can Mirror Severe Sporadic Disease After Cadaveric Growth Hormone Exposure
Four men exposed in childhood to cadaveric pituitary-derived human growth hormone developed dementia decades later; one autopsied case showed severe Alzheimer-type pathology, including tauopathy, supporting a transmissible iatrogenic Alzhei
Patient-Derived Medullary Thyroid Cancer Models Capture Tumor Plasticity and Drug Resistance Beyond Genomics
Patient-derived medullary thyroid cancer models preserved tumor heterogeneity, microenvironmental stem-like features, and variable tyrosine kinase inhibitor response, supporting more personalized preclinical testing.
FT3/FT4 Ratio Emerges as a Practical Predictor of Relapse After Antithyroid Drug Withdrawal in Children
In pediatric autoimmune hyperthyroidism, a higher FT3/FT4 ratio predicted relapse after antithyroid drug withdrawal, especially when orbitopathy was present.
Precision Phenotyping in Cardiometabolic Medicine: Genetic Susceptibility of Diabetes Subtypes and Coronary Artery Disease Risk
This review synthesizes evidence on the genetic architecture of adult-onset diabetes subtypes, highlighting that Moderate Obesity-related Diabetes (MOD) is uniquely and causally linked to coronary artery disease risk through polygenic and M
STEMI and NSTEMI Are Not the Same in Type 1 Diabetes: Finnish Cohort Reveals Distinct Risk Patterns
In Finnish adults with type 1 diabetes, STEMI and NSTEMI showed distinct incidence trends and risk profiles. NSTEMI was more common overall and linked to dyslipidemia and advanced microvascular disease, whereas impaired eGFR tracked more wi
Long-Term Durability and Clinical Stability of Acoramidis in Transthyretin Amyloid Cardiomyopathy: A 54-Month Synthesis
This review synthesizes the 54-month results of the ATTRibute-CM open-label extension, demonstrating that early and continuous acoramidis treatment provides sustained reductions in mortality and cardiovascular hospitalizations while maintai
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