Latest news
5033 articles · 20 / page
Integrating Rare and Common Variants: The Synergistic Role of rCNVs and Polygenic Scores in Psychiatric Risk Stratification
This review synthesizes evidence on how recurrent copy number variants (rCNVs) and polygenic scores (PGSs) jointly influence psychiatric risk, highlighting their complementary roles in clinical risk assessment and the emergence of precision
Four Oxygenation Trajectories Define Reproducible Clinical Archetypes in Persistent Acute Respiratory Failure
A multi-cohort study identified four reproducible 14-day oxygenation trajectory classes in persistent acute hypoxemic respiratory failure, with distinct mortality, biomarker patterns, and links to ARDS and hyperinflammatory subphenotypes.
Liberal Transfusion Still Appears Favored in Myocardial Infarction With Anemia, Regardless of Critical Illness Status
A MINT trial subanalysis found no evidence that ICU status changes the relative effect of restrictive versus liberal transfusion in acute myocardial infarction with anemia.
Digital Shared Decision Support Increased STI Testing for Adolescents and Young Adults in the Emergency Department
In a randomized controlled trial, the STIckER smartphone-based decision aid increased gonorrhea/chlamydia and pharyngeal STI testing in emergency department patients aged 14 to 24 years, while improving decisional clarity, satisfaction, and
VA Health Professions Trainees Were Disrupted by COVID-19 but Became Meaningful Contributors to Clinical Care, Telehealth, and System Response
A qualitative VA study found that COVID-19 reduced trainee learning opportunities and heightened safety concerns, yet trainees contributed substantially to care delivery, telehealth expansion, patient support, and local pandemic planning.
Medicare Advantage Enforcement Has Been Inconsistent and Financially Modest Despite Expanding Federal Exposure
A 2010-2023 analysis found that CMS enforcement against Medicare Advantage plans was highly variable, usually limited to modest monetary penalties, and more common among lower-rated contracts serving more socially vulnerable beneficiaries.
Two-Year SURPASS-EARLY Findings Show Tirzepatide Outperforms Intensified Conventional Care in Early Type 2 Diabetes
In adults with early type 2 diabetes inadequately controlled on metformin, tirzepatide produced greater 2-year reductions in HbA1c, body weight, and waist circumference than intensified conventional care, with substantially higher rates of
Tirzepatide Versus Intensified Conventional Care After 2 Years in Early Type 2 Diabetes
In early type 2 diabetes uncontrolled on metformin, tirzepatide produced greater 2-year reductions in HbA1c, weight, and waist circumference than intensified conventional care, with more patients achieving normoglycemia.
EBMT Crosses One Million Transplants as Allogeneic HCT and CAR-T Reach New Highs in European Cellular Therapy
The 2024 EBMT activity report marks a major cellular therapy milestone, showing record allogeneic HCT, continued CAR-T expansion, and persistent disparities in donor use, pediatric activity, and country-level access.
The 2024 EBMT Activity Report: Crossing One Million HCTs and 20,000 CAR-T, a Landmark in Cellular Therapy
EBMT’s 2024 report marks over one million reported stem cell transplants and continued rapid CAR-T growth, highlighting shifts in indications, donor use, and access across Europe.
Next-Generation Sequencing MRD Detection Predicts Outcomes in AML Patients Undergoing Allogeneic Stem Cell Transplantation
A low-cost NGS-based MRD test detected hidden AML cells before transplant and strongly predicted worse survival after allogeneic stem cell transplantation.
Targeting Ibrutinib Resistance Pathways with miR-28 in ABC-DLBCL
miR-28 suppresses the emergence of ibrutinib resistance in ABC-DLBCL by disrupting clonal selection and dampening mitochondrial and mTOR signaling, with promising preclinical nanoparticle delivery results.
Regulatory-like FOXP3+Helios+CD4+ T Conventional Cells Correlate with T-Cell Activation After Orca-T Immunotherapy
A study of leukemia patients found that Orca-T transplant therapy increases a regulatory-like CD4+FOXP3+Helios+ T-cell subset early after treatment, and this subset correlates with later T-cell activation, offering a potential biomarker for
When Severe Mental Illness Meets Lung Cancer: Why Equal Treatment Still Isn’t Guaranteed
A large Japanese study found that people with schizophrenia spectrum disorders were less likely to receive several standard treatments for non-small cell lung cancer, underscoring a persistent and preventable gap in cancer care.
Patients With Schizophrenia Spectrum Disorder Are Less Likely to Receive Stage-Appropriate Treatment for Non-Small Cell Lung Cancer in Japan
A nationwide Japanese cohort study found that patients with schizophrenia spectrum disorder and NSCLC presented with more advanced disease and were less likely to receive surgery, adjuvant chemotherapy, or systemic therapy.
Twice-Yearly Depemokimab Maintained Asthma Control After Switching From Mepolizumab or Benralizumab, but Did Not Meet Formal Noninferiority for Exacerbations
In the phase 3A NIMBLE trial, switching biologic-responsive severe asthma patients to twice-yearly depemokimab preserved overall control and showed comparable safety, but formal noninferiority versus continued mepolizumab or benralizumab fo
Optical Coherence Tomography Features of Inactive Multifocal Choroiditis with Panuveitis and Punctate Inner Choroidopathy Lesions
OCT imaging revealed that inactive MFCPU/PIC lesions commonly show Bruch’s membrane disruption, inner retinal herniation, and focal choroidal excavation, helping distinguish them from inflammatory and infectious mimickers.
Ocular Inflammation Linked to Higher Risk of Anti-Adalimumab Antibodies in Autoimmune Disease Patients
Ocular inflammation was linked to a higher risk of anti-adalimumab antibody formation in patients treated with adalimumab. More than 20% developed antibodies, supporting closer monitoring and therapeutic drug testing in high-risk patients.
Frenotomy Use in Danish Infants More Than Doubled Over a Decade, With Marked Geographic Variation and Limited Signals of Serious Harm
A nationwide Danish cohort study found rapid growth in infant frenotomy, wide municipal variation, and rare severe complications, raising questions about clinical appropriateness in the setting of limited evidence for benefit.
Nebulized Ciprofloxacin-Dexamethasone Appears Well Tolerated After Pediatric Airway Surgery in a Large Retrospective Cohort
A single-center retrospective study of 399 pediatric airway surgery patients found no significant adverse events clearly linked to postoperative nebulized ciprofloxacin-dexamethasone, supporting short-term safety while leaving efficacy and
Browse by specialty
Open language-specific specialty feeds and department pages.