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Rethinking Magnesium Prophylaxis for Postoperative Atrial Fibrillation in Cardiac Surgery: A Synthesis of Clinical Evidence
Recent high-quality randomized clinical trials and meta-analyses suggest that routine magnesium sulfate infusion does not effectively prevent postoperative atrial fibrillation in cardiac surgery, especially when used alongside standard beta
Extracorporeal CPR May Improve Survival After Pediatric Out-of-Hospital Cardiac Arrest, but Evidence Remains Early
A Japanese multicenter registry study suggests ECPR may improve 1-month survival and neurologic outcomes in selected children with out-of-hospital cardiac arrest, although estimates were imprecise and residual confounding remains a major li
Extracorporeal Cardiopulmonary Resuscitation for Pediatric Out-of-Hospital Cardiac Arrest
In selected children with out-of-hospital cardiac arrest, extracorporeal CPR was associated with higher one-month survival and better neurologic outcomes than continued conventional CPR, though the study was observational and estimates were
Patient Preference Phenotypes for Post-operative Anticoagulation After Hip or Knee Replacement
A survey study found three distinct patient preference patterns for anticoagulation after hip or knee replacement: clot-prevention focused, balanced, and cost-focused. These differences may help personalize postoperative blood thinner choic
Patient Preference Phenotypes for Post-operative Anticoagulation After Hip or Knee Replacement: A Cross-sectional Survey Study
A survey study found three distinct patient preference patterns for anticoagulation after hip or knee replacement, highlighting the importance of shared decision-making based on clot risk, bleeding risk, and cost.
Regulatory Framework for Private Equity and Corporatization in Health Care: An ACP Position Paper
ACP warns that private equity in health care can raise costs, weaken clinical autonomy, and affect access and quality, calling for stronger transparency, oversight, and protections for physicians and patients.
Early High-Resolution Immune Profiles Are Linked to Survival and Relapse After Allogeneic Stem Cell Transplantation
Early immune profiling after allogeneic stem cell transplant was linked to survival and relapse risk. Stronger innate and adaptive immune recovery predicted better outcomes, while certain activation and checkpoint markers were associated wi
Twice-Weekly All-Oral Ixazomib, Pomalidomide, and Dexamethasone Shows Durable Activity in Relapsed/Refractory Multiple Myeloma
A phase I/II study suggests twice-weekly ixazomib plus pomalidomide-dexamethasone is a feasible all-oral option in relapsed/refractory multiple myeloma, with a 65.8% response rate at the RP2D and manageable hematologic toxicity.
Cellular and Molecular Mechanisms of Relapse After CD19/CD22 Dual-Target CAR T-Cell Therapy in B-Cell Acute Lymphoblastic Leukemia
A study of 91 B-ALL patients found that relapse after CD19/CD22 dual-target CAR T-cell therapy is mainly driven by CAR T-cell functional failure and antigen loss, with PAX5 mutations linked to early immune escape.
Anti-CD117 Conditioning With Briquilimab Shows Feasibility and Stem-Cell Depletion in Older Adults Undergoing Allogeneic Transplant for High-Risk AML and MDS
A phase 1 trial suggests briquilimab can be safely added to nonmyeloablative conditioning before allogeneic transplant in older adults with high-risk AML or MDS, with biologic evidence of hematopoietic stem/progenitor cell depletion and enc
CT Small-Artery Loss Tracks Severe Pulmonary Hypertension in COPD and Fibrosing ILD More Closely Than Parenchymal Damage
CT-derived pulmonary vascular metrics, especially the small-artery to total arterial volume ratio, identify severe pulmonary hypertension in chronic lung disease, with distinct vascular remodeling patterns in COPD and fibrosing ILD.
International Validation of Electronic Nose Technology as a Diagnostic Tool for Fibrotic Interstitial Lung Diseases
An international study found that electronic nose breath analysis can distinguish fibrotic interstitial lung disease subtypes with good accuracy, suggesting a promising noninvasive tool to support diagnosis.
International Validation of Electronic Nose Technology as a Diagnostic Tool for Fibrotic Interstitial Lung Diseases
An international multicenter study found that electronic nose breath analysis can help distinguish fibrotic interstitial lung disease subtypes with promising accuracy, offering a noninvasive diagnostic aid.
Progression in Preperimetric Glaucoma Eyes With and Without Microvasculature Dropout
In preperimetric glaucoma, baseline microvasculature dropout on OCTA predicted faster capillary density loss and a higher risk of later visual field damage, suggesting it may help identify eyes needing closer follow-up.
Progression in Preperimetric Glaucoma Eyes With and Without Microvasculature Dropout
Eyes with preperimetric glaucoma and baseline microvasculature dropout progressed faster in capillary density loss and were more likely to develop visual field damage.
Pathologic Myopia Globe Shape and Long-Term Prognosis
Three-dimensional eye shape on MRI predicted 15-year outcomes in high myopia. Nasally distorted and conical eyes had the highest risk of rapid elongation, macular thinning, myopic degeneration, and visual field defects.
Clinical Care Guideline Implementation of Nebulized Tranexamic Acid in Post-Tonsillectomy Hemorrhage
A clinical care guideline improved emergency use of nebulized tranexamic acid for post-tonsillectomy bleeding and was associated with fewer returns to the operating room.
A Post-Tonsillectomy Hemorrhage Guideline Using Nebulized Tranexamic Acid Was Associated With Fewer Returns to the Operating Room
A quality-improvement clinical care guideline for nebulized tranexamic acid in post-tonsillectomy hemorrhage achieved high protocol adherence and was associated with a marked reduction in operative intervention.
Clinical Care Guideline Implementation of Nebulized Tranexamic Acid in Post-Tonsillectomy Hemorrhage
A clinical care guideline for nebulized tranexamic acid in post-tonsillectomy hemorrhage was rapidly adopted in the Emergency Department and was associated with fewer returns to the operating room.
A Clinical Care Guideline for Nebulized Tranexamic Acid Was Associated With Fewer Operating Room Returns After Post-Tonsillectomy Hemorrhage
A structured emergency department guideline for nebulized tranexamic acid in post-tonsillectomy hemorrhage achieved rapid protocol uptake and was associated with a marked reduction in operative hemorrhage control.
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