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A statewide Australian cohort study reveals lithium exposure during pregnancy doubles risk of spontaneous preterm birth and raises risks of cardiac malformations and large-for-gestational-age infants, informing clinical decision-making.
This review synthesizes randomized trial evidence demonstrating that intermittent theta burst stimulation (iTBS) targeting the dorsomedial PFC modulates default mode network activity, enhancing expectancy-driven placebo mood responses in de
This randomized clinical trial evaluated mirtazapine’s safety and efficacy for methamphetamine use disorder, revealing a modest but statistically significant reduction in methamphetamine use without unexpected adverse events, offering
This study reveals that dementia in severe, treatment-resistant schizophrenia exhibits a unique cognitive profile distinct from common neurodegenerative dementias and lacks typical genetic markers such as APOE4, highlighting a novel dementi
This study reveals that general anesthesia selectively modulates ketamine-induced EEG changes, preserving beta-gamma oscillations while attenuating theta augmentation, highlighting discrete neurophysiologic components underlying ketamine
A qualitative study across 12 Colorado hospitals found that an EHR-embedded OUD intervention improved awareness but still faced stigma, inconsistent messaging, limited addiction expertise, and workflow barriers to MOUD initiation.
A randomized trial found that an 8-week digital mindfulness app improved anxiety, depression, and stress in adults with non-infectious uveitis, but did not significantly change vision-related quality of life.
In treated Cushing syndrome, normal late-night salivary cortisol was linked to better mood, quality of life, and metabolic outcomes, suggesting circadian cortisol restoration may be a meaningful recovery target.
In a nationwide Finnish cohort, earlier ADHD diagnosis was linked to better school performance, more academic progression, and less dropout than diagnosis closer to age 16, especially before educational track selection.
Qualitative interviews show family PTSD after ICU care is shaped by cumulative stressors across the illness trajectory, highlighting the need for continuous, family-centered communication and support.
A large single-center study found that hospitalized patients with limited English proficiency had higher adjusted odds of physical restraint or antipsychotic use, especially when delirium was present, raising concerns about communication-dr
A large study of veterans with cancer found persistent risk of suicidal self-directed violence, especially in younger, unmarried, frail, or mentally ill patients and those with central nervous system, head and neck, or thyroid cancers.
A 2026 review shows that many patients with acromegaly remain symptomatic and functionally impaired despite biochemical control, underscoring the need for routine patient-reported outcomes and lower-burden, multidisciplinary care.
A multisite case-control study found repulsive serial bias in schizophrenia, attractive bias in healthy controls, and mixed patterns in bipolar disorder, supporting serial dependence as a potential cognitive biomarker across the psychosis s
A 145-publication scoping review finds that ED medical screening of adults with psychiatric complaints is dominated by low-level evidence, with society statements generally discouraging routine laboratory testing in otherwise low-risk patie
In a phase 3 randomized withdrawal trial, ecopipam maintained tic improvement in pediatric Tourette syndrome over 24 weeks and showed a generally favorable safety profile without clinically meaningful weight, metabolic, or drug-induced move
Magnetic seizure therapy was non-inferior to right unilateral ultra-brief ECT for depression remission and caused less autobiographical memory worsening, suggesting a promising convulsive treatment option with better cognitive safety.
A small randomized trial found that blocking IL-6 with tocilizumab showed promising, clinically meaningful trends for inflammation-related, hard-to-treat depression, especially for somatic symptoms, fatigue, anxiety, and quality of life, th
A 6-year follow-up of guided internet-based CBT for tinnitus found sustained reductions in tinnitus distress, with smaller persistent gains in mood and sleep, despite substantial attrition and the absence of a long-term control group.
A 6-year follow-up study suggests guided internet-based CBT for tinnitus can produce durable reductions in tinnitus distress, with sustained but smaller benefits for mood, insomnia, and life satisfaction.
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