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This article evaluates the clinical evidence supporting leucovorin for autism spectrum disorder and examines the FDA’s controversial proposal to expand its indications based on mechanistic data rather than traditional large-scale clin
The IVAM-ED trial demonstrates that interactive virtual assistants significantly reduce mental distress and improve HbA1c levels in older adults with type 2 diabetes, highlighting a scalable solution for geriatric chronic disease management
This article compares the Ketogenic and Mediterranean diets’ impact on cardiovascular markers and mental health, highlighting results from two recent pilot studies on blood pressure and the gut-brain axis.
A randomized clinical trial demonstrates that an 8-week Acceptance and Commitment Therapy (ACT) program significantly reduces parental stress and improves psychological flexibility and parenting competence, while also yielding positive seco
The HAMLETT trial demonstrates that early dose reduction after first-episode psychosis increases short-term relapse risk but correlates with superior functional outcomes at three to four years, suggesting a potential ‘learning effect&
The EMPOWER-ED randomized clinical trial demonstrates that an electronic, patient-centered intervention significantly increases the odds of complete benzodiazepine cessation among long-term users, providing a scalable, low-cost solution for
Highlights Background Dementia and depression are intertwined public health crises, together accounting for a substantial...
A randomized clinical trial demonstrates that telehealth-delivered music therapy is noninferior to cognitive behavioral therapy for reducing anxiety in cancer survivors, providing durable, clinically meaningful improvements and a viable alt
A population-based study reveals that nearly one-quarter of TIA patients experience depression, which significantly increases the risk of mortality and disability, regardless of whether acute ischemic lesions are present on imaging.
A large-scale nationwide study reveals that individuals with atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction and stroke, face a 43% higher risk of suicide. The risk nearly doubles for those suffering from bot
This large-scale study of 35,751 children characterizes ARFI phenotypes, revealing a 6.3% clinical prevalence and significant genetic heritability. Findings link ARFI to the ADCY3 locus and long-term neurodevelopmental difficulties, emphasi
A large-scale cohort study demonstrates that while hormonal contraceptives are generally associated with lower cardiovascular risk in women, this protective effect is lost in those with PTSD, highlighting a critical intersection between psy
A multi-center randomized clinical trial involving 257 youths found that adjunctive omega-3 fatty acids (1.5 g/d) did not outperform placebo in treating moderate-to-severe pediatric major depressive disorder, despite high adherence and conc
A randomized clinical trial demonstrates that smartphone-based ecological momentary assessment (EMA) is significantly more sensitive than retrospective questionnaires in detecting the daytime clinical benefits of suvorexant, particularly re
A prospective study reveals that patients with mental health conditions face significant delays in STEMI diagnosis, resulting in larger infarct sizes and a twofold increase in five-year cardiovascular mortality compared to those without suc
Experts have released the VasCog-2-WSO criteria, an updated international standard for diagnosing vascular cognitive impairment and dementia. This revision introduces a preclinical stage and incorporates modern neuroimaging and fluid biomar
The CLARO randomized clinical trial investigated whether a collaborative care model could improve outcomes for patients with opioid use disorder and co-occurring depression or PTSD. The study found no statistically significant advantages ov
A multicenter trial finds low-dose amitriptyline non-inferior to CBT-I for comorbid insomnia based on a liberal margin. However, CBT-I yielded superior clinical response rates and fewer side effects, reinforcing its status as the gold-stand
A randomized trial comparing Tai Chi and CBT-I in adults over 50 found that while CBT-I offers faster relief, Tai Chi achieves non-inferior results at 12 months post-intervention, suggesting it is a viable long-term strategy for insomnia ma
A comprehensive BMJ umbrella review synthesizes evidence for ADHD interventions across the lifespan, confirming the efficacy of stimulants and non-stimulants in the short term while revealing a critical lack of high-certainty long-term data
