Psychiatry
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Unraveling Chronic Stress: The Role of Gut Dysbiosis and Vitamin B6 Metabolism in Stress-Related Brain Disorders Independent of Cortisol
Recent evidence reveals gut dysbiosis-induced vitamin B6 metabolic disturbances as a novel, cortisol-independent mechanism driving chronic stress-related abnormal behaviors and inflammation, highlighting probiotic and vitamin B6 supplementa
Optimizing Smoking Cessation in Major Depressive Disorder: Varenicline Outperforms Bupropion and Nicotine Patch with Comparable Safety
This analysis reveals that varenicline is the most effective and safe pharmacotherapy for smoking cessation in individuals with current or past major depressive disorder, outperforming bupropion and nicotine patches with no increased neurop
Evaluating the Role of AI Tools in Pharmacy Students’ OSCE Performance and Anxiety: Insights from a Randomized Controlled Trial
A randomized trial assessing AI-generated study materials revealed no significant impact on pharmacy students’ objective structured clinical examination scores or test anxiety levels, highlighting the need for further research on long-term
Enhancing Depression Care in College Students: AI Chatbots with Social Cues Show Superior Effectiveness
A 16-week randomized trial demonstrates that AI chatbots with high-social-cue design significantly reduce depression and anxiety symptoms in college students compared to text-only chatbots, improving adherence, satisfaction, and therapeutic
Harnessing Slow-Wave Sleep for Internet Gaming Disorder: Efficacy of Closed-Loop Auditory Exposure
Closed-loop auditory exposure during slow-wave sleep significantly reduces craving and playtime in Internet Gaming Disorder by modulating sleep spindle power, offering a novel, non-invasive therapeutic strategy.
Reducing Carcinogen Exposure in Smokers with Serious Mental Illness: Insights from a Randomized Controlled Trial of E-Cigarette Provision
This RCT demonstrates that disposable e-cigarettes significantly reduce carcinogen levels short-term among smokers with serious mental illness, underscoring the need for behavioral support to sustain harm reduction.
Esketamine in Lung Cancer Patients with Major Depression: Efficacy for Smoking Cessation and Treatment-Resistant Depression
This review synthesizes evidence from a randomized trial and real-world studies showing esketamine’s efficacy and safety in smoking cessation among lung cancer patients with MDD, as well as in treatment-resistant depression, highlighting co
Does Increasing Cigarette Use Stabilize Mood? Insights from a 6-Year Real-Time Adolescent Study
Longitudinal observational data reveal that as adolescents increase cigarette use, their immediate post-smoking mood stabilizes, with boys showing stabilization in background mood as well.
Evaluating a Proactive E-Health Intervention for Co-occurring At-Risk Alcohol Use and Depressive Symptoms: Adherence, Reach, and Two-Year Outcomes
This RCT assessed a proactive e-health intervention for patients with at-risk alcohol use and depressive symptoms, showing high adherence but only small, non-significant improvements at 12 months and no lasting effects at 24 months.
Clozapine and Infection Risk in Schizophrenia: Insights from a Hong Kong Population Study
This study reveals an increased risk of infections among schizophrenia patients treated with clozapine compared to olanzapine, highlighting the need for vigilant infection monitoring and preventive care.
Depression and Anxiety Rates Increased Among Racial Groups During the Pandemic
A survey reveals significant increases in depression and anxiety rates among various racial groups during the COVID-19 pandemic, highlighting ongoing racial health disparities.
Efficacy and Safety of ALM-003 Digital Therapeutic in Alcohol Dependence: A Multicenter Open-Label Randomized Controlled Trial
This review synthesizes evidence from a multicenter RCT showing ALM-003 digital therapeutic reduces heavy drinking days significantly in alcohol-dependent individuals at high risk, with an excellent safety profile.
Digital Therapeutics in Suicide Prevention: Evidence and Clinical Implications of a Smartphone-Based CBT Intervention
Smartphone-delivered cognitive-behavioral therapy (CBT) via a digital therapeutic app significantly reduces recurrent suicide attempts and sustains reduction in suicidal ideation among adults with prior suicide attempts.
Transcranial Magnetic Stimulation: Clinical Advances, Challenges, and Emerging Research Trends
This review synthesizes recent clinical evidence on transcranial magnetic stimulation across neurological and psychiatric disorders, highlighting efficacy, optimization challenges, and future research directions.
Childhood Verbal and Physical Abuse Harm Adult Mental Health
Research shows childhood abuse significantly increases the risk of poor adult mental health, with lasting impacts from physical and verbal abuse.
4 Steps for Keeping a Residency Romance Alive and Thriving
A guide to maintaining romantic relationships during medical residency, focusing on time management, emotional support, and communication strategies to navigate the challenges that might arise.
Understanding Female Sexual Arousal Disorder: Causes, Misconceptions, and Path to Wellness
This article explores why women may experience low sexual desire, examining psychological, physiological, and lifestyle factors, while offering practical insights to improve sexual health and wellbeing.
The Truth About Senior Intimacy: Why Moderate Sexual Activity Benefits Physical and Mental Health
Moderate sexual activity in older adults supports emotional well-being, cardiovascular health, and physiological function, debunking myths about risks and affirming intimacy’s role in healthy aging.
Illinois Takes a Stand Against AI in Mental Health Therapy
Illinois has enacted legislation banning AI chatbots for mental health therapy, joining Utah and Nevada in addressing concerns over AI’s impact on vulnerable populations.
Navigating Mental Health in Vietnam: The Rise of Social Media Solutions Among Youth
Vietnamese adolescents face notable mental health challenges amid growing social media influence. This article explores the alarming statistics, the stigma surrounding mental health, and the emerging role of social media in providing suppor
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