Psychiatry
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Automated Tobacco Cessation for Parents in Pediatric Care: A Cluster-Randomized Trial Insights
This cluster-randomized trial evaluated an automated tobacco cessation intervention for parents in pediatric primary care, finding no significant increase in 1-year quit rates but notable improvements in treatment engagement and smoking red

Esketamine Monotherapy for Treatment-Resistant Depression: A New Therapeutic Frontier
A phase 4 randomized trial demonstrates that esketamine nasal spray monotherapy significantly reduces depressive symptoms in adults with treatment-resistant depression, offering a promising alternative to oral antidepressants.

Cannabidiol Use and Liver Enzyme Elevations: Insights from a Randomized Clinical Trial in Healthy Adults
A 4-week randomized trial shows that low-dose cannabidiol (CBD) may cause transient liver enzyme elevations in healthy adults, emphasizing the need for vigilance and further safety assessment of consumer CBD products.

Enhancing Opioid Use Disorder Care in Primary Settings: Impact of an EHR-Integrated Clinical Decision Support System
A cluster randomized trial demonstrates that an electronic health record–integrated clinical decision support system increases naloxone prescriptions and opioid use disorder treatments in primary care but does not change diagnosis rates or

Empowering Mental Health in Inflammatory Rheumatic Diseases Through Digital Interventions: Insights from a Pilot Randomized Clinical Trial
A pilot study demonstrates that a self-guided digital psychological intervention significantly reduces psychological distress and improves quality of life in patients with inflammatory rheumatic diseases, offering a scalable mental health s

Harnessing Digital Psychological Interventions to Improve Mental Health in Inflammatory Rheumatic Diseases: Insights from a Pilot Randomized Clinical Trial
A pilot randomized clinical trial demonstrates that a self-guided digital psychological intervention effectively reduces psychological distress and improves quality of life among patients with inflammatory rheumatic diseases.

Pro-Inflammatory Diets Elevate Risk of Depression and Anxiety: Insights from a Large UK Biobank Study
A prospective UK Biobank study reveals that diets with higher pro-inflammatory potential, as measured by the Dietary Inflammatory Index, are significantly associated with increased risk of depressive and anxiety symptoms and disorders over

Midazolam Outperforms Melatonin as Premedication for Anxiety in Children Undergoing Elective Surgery: Insights from the MAGIC Trial
The MAGIC trial reveals midazolam’s superior efficacy over melatonin in reducing preoperative anxiety in children undergoing general anaesthesia, despite melatonin’s favorable safety profile. Challenges in recruitment and implications for f

Unlocking Mental Health in Children with Chronic Illness: The Crucial Roles of Physical Activity and Social Play
Children with chronic physical illnesses face higher risks of mental health issues, partly due to early-life constraints on social and physical activities. Encouraging active play and social engagement may reduce these risks.

Increased Risk of Psychiatric Disorders in Patients with Microscopic Colitis: Insights from a Nationwide Swedish Cohort Study
A comprehensive Swedish study reveals that patients with microscopic colitis face a significantly higher risk of developing psychiatric disorders such as depression and anxiety, underscoring the importance of holistic clinical management.

Impact of Screening and Care for Emotional and Cognitive Problems on Post-Ischemic Stroke Outcomes: Insights from a Dutch Multicenter Cluster-Randomized Trial
A multicenter trial assessing emotional and cognitive screening post-ischemic stroke found no improvement in societal participation at 1 year, though modest early benefits in anxiety and quality of life were noted.

Risk of New-Onset and Recurrent Depression and Anxiety Among Patients With Hidradenitis Suppurativa
Patients with hidradenitis suppurativa face a higher risk of first-time depression and anxiety, regardless of disease severity, highlighting the need for comprehensive psychiatric care.

Elevated Risk of Depression and Anxiety in Hidradenitis Suppurativa: Implications Beyond Disease Severity
Patients with hidradenitis suppurativa face a significantly increased risk of new-onset depression and anxiety, independent of disease severity, highlighting the need for universal psychiatric assessment in this population.

Reducing TV Time and Boosting Physical Activity: A Key Strategy to Prevent Depression in Middle-Aged Adults
A large Dutch cohort study reveals that substituting TV-watching time with physical activities or sleep significantly lowers major depression risk, especially in middle-aged adults, highlighting the mental health benefits of an active lifes

Novel Benzodiazepines Intensify Opioid Overdose Severity: A Multicenter ED Study
Novel benzodiazepine coexposure in opioid overdoses significantly increases the risk of mechanical ventilation and naloxone nonresponse, highlighting a critical challenge in emergency care management.

ADHD Drugmakers Double Marketing Spending to Clinicians: Implications for Prescribing and Patient Care
Pharmaceutical companies have significantly increased marketing payments to clinicians for ADHD medications, particularly targeting advanced practice clinicians. The impact of this trend on prescribing patterns and clinical benefits remains

Eat Your Way to a Better Mood and Cancer Prevention: 9 Foods That Boost Mental and Physical Health
Discover nine brain- and body-friendly foods that improve mood, reduce inflammation, stabilize blood sugar, and offer potential cancer-protective benefits, supporting both emotional well-being and long-term health.

Preoperative Anxiety as a Key Predictor of Postoperative Delirium: Insights from a Year-Long Cohort Study
A prospective study reveals that nearly 20% of surgical patients experience postoperative delirium in the PACU, with elevated preoperative anxiety significantly increasing this risk. Implementation of a brain health care bundle improves man

Unraveling the Link Between Gastrointestinal Disorders and Sleep Problems: The Role of Depression
This article explores how gastrointestinal diseases are linked to sleep disturbances, highlighting depression as a partial mediator and emphasizing the importance of addressing both gut and psychological health to improve sleep quality.

Precision Psychiatry Roadmap: Integrating Biology into Mental Disorder Classification and Treatment
Mental disorders currently diagnosed symptomatically can be redefined using biology-informed frameworks integrating biological, behavioral, and environmental data. The Precision Psychiatry Roadmap aims to harmonize global research and clini
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