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Polygenic Influences and Anticholinergic Burden: Unraveling Their Joint Impact on Cognition and Brain Structure in Psychosis Spectrum Disorders

MedXY Editorial Team•Oct 30, 2025•Neurology
brain structurecognitionPolygenic ScoresPsychosis

Highlight

1. Anticholinergic burden (AChB) from medications is linked to poorer cognitive performance and decreased total gray matter volume in individuals with psychosis spectrum disorders.

2. Polygenic scores (PGSs) for cognition and psychiatric disorders modify the impact of AChB on cognitive outcomes and brain structure, demonstrating significant gene-by-environment interactions.

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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