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A pooled analysis from 22 countries demonstrates that rotavirus vaccination is highly effective in preventing rotavirus-positive acute gastroenteritis deaths in children under five, underscoring the vaccine’s critical role in reducing
This cohort study links changes in emergency department pediatric readiness and inpatient pediatric services over ten years with excess child mortality, highlighting the critical role of hospital preparedness in pediatric survival.
A 2-week-old neonate developed congenital tuberculosis despite an asymptomatic mother, illustrating diagnostic challenges and the need for heightened awareness of TB in pregnancy.
Elevated glucocorticoids, androgens, and progesterone metabolites, combined with high BMI and stress, accelerate the onset of puberty in girls, particularly breast development (thelarche).
Rigosertib demonstrates significant reversal of hypertrophic cardiomyopathy and other syndromic features in Noonan syndrome models, highlighting its potential as a targeted therapy for RASopathy-associated cardiac and developmental abnormal
Pediatric button battery ingestions increased over 15 years, with larger batteries and more esophageal impactions. Delays in caregiver recognition drive prolonged exposure, contributing to serious complications. Public awareness is crucial
This study reveals how HIF2 activation drives coronary artery remodeling, inflammation, and thrombosis in a mouse model mirroring severe Kawasaki disease, uncovering new therapeutic targets for coronary complications.
The NEAT phase 3 trial evaluated erythrocyte-encapsulated dexamethasone sodium phosphate in children with ataxia telangiectasia aged 6–9 years, confirming safety but failing to demonstrate statistically significant neurological improvement
This longitudinal study characterizes symptom variability and outcomes of respiratory infections among young children, revealing age-specific severity patterns and notable differences between influenza A and B.
This review synthesizes current evidence on neurodevelopmental outcomes after treating retinopathy of prematurity with anti-VEGF injections versus laser photocoagulation, finding no significant differences in long-term cognitive or developm
Pediatric and young adult survivors of differentiated thyroid cancer face a significant long-term risk of second primary malignancies, especially with radioactive iodine treatment, highlighting the need for extended surveillance and tailore
This nonrandomized clinical trial demonstrates the surgical feasibility of fetoscopic spina bifida repair using a human umbilical cord meningeal patch, showing comparable perinatal outcomes to open repair while enabling vaginal delivery and
This review synthesizes evidence linking smartphone acquisition and use at age 13 to depression, obesity, and sleep insufficiency at age 14, highlighting that use intensity rather than mere acquisition mediates health risks, with behavioral
A 14-year follow-up of twins exposed prenatally to 17-OHPC shows no significant effects on mortality, cognition, or development, indicating its long-term safety in multiple pregnancies.
We report five pediatric MEN2B cases highlighting early extra-endocrine signs such as persistent constipation and alacrimia, enabling prompt genetic diagnosis and thyroidectomy before medullary thyroid carcinoma progression.
A national study reveals significant variability across EMS agencies in decisions about resuscitation futility and termination for pediatric out-of-hospital cardiac arrests, highlighting critical impacts on care and outcomes.
Early exclusive enteral feeding in preterm infants is associated with faster feeding advancement and shorter hospital stay without increased risks of necrotizing enterocolitis or infection, suggesting it is a feasible and beneficial nutriti
A phase II basket trial demonstrates that vosoritide significantly increases growth velocity in children with RASopathies, ACAN, and NPR2 deficiencies, with an acceptable short-term safety profile, suggesting its potential as a precision th
This multicenter study reveals improved outcomes in fetal cardiomyopathy, highlights genetic underpinnings in one-third of cases, and identifies fetal hydrops and extracardiac anomalies as key prenatal risk factors for mortality.
This review synthesizes evidence on dual-sided composite defocus (DSCD) spectacle lenses, demonstrating significant myopia progression reduction and axial elongation control in children, contextualized within broader spectacle-based interve
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