Poverty Exposure in Standard-Risk Pediatric B-ALL Is Linked to Steroid-Resistance Programs and an Immunologically Suppressed Leukemia Microenvironment
Highlights
Children with standard-risk B-cell acute lymphoblastic leukemia who were exposed to poverty showed leukemic blast transcriptional programs consistent with steroid resistance at diagnosis, before therapy had begun.
Single-cell RNA sequencing also identified a leukemia microenvironment characterized by heightened inflammatory signatures in myeloid cells and reduced effector programs in CD8+ T cells.
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.