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A multicategory study reveals 2.5% of pediatric IBD patients harbor IL-10-neutralising autoantibodies associated with severe disease and HLA-DRB1*01:03 allele, underscoring a distinct pathogenic subgroup.
This multicenter study identifies peripheral blood stem cell use as a key risk factor for early inflammatory complications post-haploidentical HSCT in children, linking these events to refractory acute and chronic graft-versus-host disease.
Temple syndrome is an under-recognised imprinting disorder with complex endocrine and growth abnormalities. This large-cohort study clarifies its phenotype, highlights growth hormone therapy benefits, and proposes a novel clinical scoring s
This multicenter observational study demonstrates that ultrasound-guided supraclavicular brachiocephalic vein cannulation is a feasible, safe, and reproducible method for central venous catheter placement in critically ill neonates, with a
A multimodal human factors program enhances team communication, nontechnical skills, and workflow during pediatric airway endoscopy, supporting OR culture change despite unchanged immediate clinical outcomes.
This study prospectively characterizes voice changes over 12 months in transmasculine adolescents and young adults receiving testosterone therapy, demonstrating significant lowering of pitch, improved voice congruence, and reduced anxiety,
Prophylactic thyroidectomy in children with MEN2 mutations shows excellent short-term cancer control but carries notable risk of permanent hypoparathyroidism, especially under age 5, highlighting the need for expert multidisciplinary surgic
Population-based genetic screening and prospective follow-up of at-risk children reduce the severity of type 1 diabetes at diagnosis and enhance one-year treatment outcomes, including lower HbA1c and insulin requirements.
This nationwide UK study identifies key factors contributing to delayed diagnosis in childhood non-infectious uveitis, underscoring the need for improved primary care awareness and streamlined referral pathways to prevent vision-threatening
New region- and sex-specific axial length centile charts provide vital reference values for myopia monitoring and management in children, highlighting regional differences and supporting targeted interventions against rising myopia rates.
Elevated maternal third-trimester TRAb levels in Graves’ disease are linked to neonatal thyroid dysfunction and impaired neurodevelopment at 24 months, independent of neonatal thyroid status, highlighting the need for prenatal monitor
A pilot study demonstrates that ChatGPT-4 can feasibly collect accurate and satisfactory medical histories from pediatric emergency patients, streamlining triage and reducing documentation burden.
This cohort study assesses the sensitivity and clinical relevance of dried blood spot PCR testing for congenital CMV in infants identified through expanded targeted screening, highlighting diagnostic strengths and limitations for universal
A phase 3 trial demonstrates that once-weekly somapacitan is non-inferior to daily growth hormone injections in promoting linear growth in girls with Turner syndrome, offering a promising alternative with comparable safety and efficacy prof
This study reveals that providing a resource menu increases caregivers’ desire for social assistance in the pediatric ED, supporting a tiered, patient-centered social care approach prioritizing preference and follow-up.
Peer networks in adolescence, especially in upper secondary school, significantly influence the risk trajectory for mental disorders through peers’ diagnosed conditions and genetic predispositions, with subtype-specific and cross-diso
BMI normalization in overweight or obese, autoantibody-positive youths lowers the risk of progression to clinical type 1 diabetes by nearly half, highlighting weight management as a critical preventive strategy in high-risk populations.
This study compares a novel retinal birefringence scanning device with a traditional autorefraction photoscreener, finding superior sensitivity of the traditional device for detecting amblyopia and refractive errors in children without comp
Endoscopic repair of congenital choanal atresia using mucoperiosteal flaps without stenting shows high long-term neochoanal patency but a significant reoperation rate, underscoring the need for diligent follow-up and tailored postoperative
This study found no association between neonatal hypoglycemia in late preterm infants and adverse neurodevelopmental outcomes at age 6 years or older.
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