Pediatrics
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Fetal Reduction in Triplet Pregnancies Significantly Reduces Neurodevelopmental Risks, Study Finds
A nationwide cohort study reveals that fetal reduction from triplets to twins lowers the long-term risk of neurodevelopmental disorders in surviving children compared to non-reduced pregnancies.
Observation Reduces CT Use in Pediatric Blunt Abdominal Trauma Without Missing Critical Injuries
A multicenter study shows that observation with deferred CT decision-making significantly reduces CT use in children with blunt abdominal trauma, particularly in cases with intermediate clinician suspicion, without increasing missed injurie
New Statistical Model Predicts Chronic ITP in Children at Diagnosis
A novel statistical model predicts chronic immune thrombocytopenia (ITP) in children at diagnosis, using age, sex, immunoglobulin levels, and lab values, offering early clinical guidance.
Open Globe Repair Carries the Highest Endophthalmitis Risk, and Pediatric Cataract Surgery Outpaces Adult Surgery in IRIS Registry Data
An IRIS Registry analysis of 17.5 million procedures found endophthalmitis was rare overall but highest after open globe repair, with pediatric cataract surgery carrying more risk than adult surgery.
Maternal Diabetes and Early Neurodevelopment: Differential Risks Emerge Across Diabetes Types and Infant Sex
A nationwide cohort study of 466,462 infants reveals that maternal pregestational diabetes significantly increases the risk of delayed developmental milestones, with type 1 diabetes conferring the highest risk and female offspring showing p
Machine Learning Falls Short in Personalizing School-Based Mindfulness for Adolescent Depression Prevention: MYRIAD Trial Insights
Secondary analysis of the MYRIAD trial reveals that while machine learning models can identify adolescents who may benefit from school-based mindfulness training, the clinical relevance of such predictions remains minimal. Both causal fores
TP53 Alterations Emerge as Critical Adverse Prognostic Factor in Pediatric and Young Adult Patients Treated with CD19-CAR T-Cell Therapy for Relapsed/Refractory B-ALL
A single-center retrospective study of 69 pediatric and young adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia reveals that TP53 alterations significantly compromise outcomes following tisagenlecleucel therapy. Pa
Real-World Evidence Confirms Burosumab Effectiveness Across All Ages in X-linked Hypophosphatemia
A 3-year prospective study demonstrates sustained biochemical and clinical improvements with burosumab in XLH patients across pediatric and adult age groups, including those typically excluded from clinical trials.
FT3/FT4 Ratio Emerges as a Practical Predictor of Relapse After Antithyroid Drug Withdrawal in Children
In pediatric autoimmune hyperthyroidism, a higher FT3/FT4 ratio predicted relapse after antithyroid drug withdrawal, especially when orbitopathy was present.
Dose-Dense Stanford V Strategy Safely Spares Radiation in Most Pediatric Patients with Low-Risk Hodgkin Lymphoma
The PHC HOD08 study demonstrates that an 8-week dose-dense modified Stanford V regimen achieves high complete response rates, allowing over 75% of low-risk pediatric Hodgkin lymphoma patients to avoid radiotherapy while maintaining an excep
Intestinal Ultrasound Scan in Acute Severe Ulcerative Colitis in Children: A Multicenter Clinical Study Report
This report examines the role of Intestinal Ultrasound (IUS) in pediatric Acute Severe Ulcerative Colitis (ASUC). Results from 60 patients show that IUS metrics, specifically colonic wall thickness and the Milan Ultrasound Score, can accura
Beyond the Motor Cortex: Functional Network Mapping Redefines Cerebral Palsy Prediction After Neonatal Stroke
A landmark study using lesion network mapping reveals that cerebral palsy after neonatal stroke is driven by disruptions in extensive functional networks, including the thalamus and cerebellum, rather than just localized motor cortex damage
Strengthening the Safety Net: Insights from the First National Assessment of EMS Pediatric Readiness
This article examines the landmark findings from the National Pediatric Prehospital Readiness Project, identifying critical gaps in emergency care for children and highlighting the transformative role of Pediatric Emergency Care Coordinator
Bridging the Gap in Emergency Care: The National Assessment of Pediatric Readiness in EMS
The first national assessment of US EMS agencies reveals a critical need for improved pediatric readiness. While equipment scores are high, significant gaps exist in quality improvement and family-centered care, with Pediatric Emergency Car
A New Standard for Pediatric Vocal Fold Immobility After Cardiac Surgery: Improving Outcomes Through Injection Laryngoplasty
Recent research highlights a standardized multidisciplinary protocol for managing unilateral vocal fold immobility in infants after cardiothoracic surgery, showing that injection laryngoplasty significantly improves oral feeding advancement
LC-MS/MS Redefines Accuracy in Congenital Adrenal Hyperplasia Newborn Screening: Reducing the False-Positive Burden
A prospective study of over 700,000 newborns demonstrates that LC-MS/MS significantly improves the positive predictive value (PPV) of CAH screening compared to traditional RIA, identifying specific steroid ratios that offer 100% PPV and red
Long-Term Thyroid Toxicity Burden in Children Who Received Treatment for High-Risk Neuroblastoma
This review analyzes the significant long-term thyroid toxicity burden in high-risk neuroblastoma survivors, identifying key risk factors such as molecular radiotherapy, tandem myeloablative therapy, and immunotherapy.
Long-Term Reality of Single-Ventricle Reconstruction: Shunt Choice, Tricuspid Regurgitation, and the Burden of Global Morbidity
A 16-year follow-up of the SVR trial reveals that while shunt types show similar long-term outcomes overall, pre-existing tricuspid regurgitation significantly impacts survival with RVPAS, amid a staggering 87% rate of major morbidity.
Beyond Height Velocity: Longitudinal Impact of Long-Acting Growth Hormone on Body Mass Index in Pediatric Growth Hormone Deficiency
This meta-analysis reveals that long-acting growth hormone (LAGH) is associated with a significant increase in BMI SD scores during the first year of treatment and upon switching from daily GH, suggesting a distinct metabolic profile compar
Beyond the Aorta: Genetic Stratification Redefines Mitral Valve Risk in Marfan Syndrome
A breakthrough study reveals that specific FBN1 genotypes, particularly in-frame variants in the DNCD region, significantly elevate the risk of early mitral valve surgery in Marfan syndrome patients, paving the way for genotype-guided clini
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