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This study examines how participant-reported outcomes relate to residual beta cell function and metabolic control in youth newly diagnosed with type 1 diabetes, highlighting modest associations with glucose management but weaker links to be
This nationwide Japanese study elucidates early clinical features of ROHHAD-NET syndrome and highlights anti-ZSCAN1 antibody titers as potential biomarkers linked to neural crest tumors and treatment response.
A study evaluating the reliability of last menstrual period dating compared to ultrasound in adolescents under 16 undergoing abortion, highlighting implications for no-test medication abortion access.
Recurrent laryngeal nerve reinnervation significantly improves voice outcomes in pediatric unilateral vocal fold paralysis, with 90% of patients showing moderate to dramatic improvement. Prematurity and intubation history influence recovery
A multicenter study reclassifies pediatric NAFLD under the steatotic liver disease framework, revealing most children meet MASLD criteria, while highlighting alcohol and medication-related reclassifications that inform diagnosis and managem
This study explores teen and caregiver perspectives on lethal means safety counseling in the emergency department, highlighting its importance, preferred tool features, and challenges involving autonomy and family dynamics, informing tailor
This study delineates phenotypic and polysomnographic differences in children with extreme versus very severe OSA, highlighting the critical role of obesity and oxygenation metrics in identifying extreme cases.
Serum bile acid levels measured within the first year after Kasai procedure accurately predict portal hypertension and high-risk esophageal varices development within five years in biliary atresia patients, offering a valuable non-invasive
This cohort study assesses the influence of hysterosalpingography with iodinated contrast on neurodevelopmental outcomes in children, revealing lower IQ scores in those conceived shortly after the procedure, warranting further investigation
This review synthesizes evidence from the ARTEMIS trial and related studies on community-based adolescent mental health care and stigma reduction, highlighting intervention efficacy, implementation challenges, and translational potentials i
A comprehensive multicenter study reveals that ovarian immature teratomas with microscopic yolk sac tumor foci in pediatric patients have favorable outcomes, showing no increased recurrence risk despite higher tumor grade and stage.
This study reveals that IL-10-neutralising autoantibodies occur in 2.1% of pediatric IBD cases without monogenic causes, persist over years, and may define a distinct clinical subgroup with specific therapeutic needs.
A phase 3 randomized, placebo-controlled crossover trial demonstrates that levacetylleucine significantly improves neurological function in ataxia-telangiectasia patients with a favorable safety profile.
This study reveals that most emergency departments rarely encounter critically ill children, and only a minority of these cases could be redirected to high-volume centers, challenging the feasibility of universal direct transport policies f
A large sibling-matched cohort study found no link between prenatal acetaminophen exposure and autism or ADHD, suggesting prior associations were confounded by familial factors and supporting the safety of indicated paracetamol use during p
Early life stress disrupts gut motility and pain regulation via enteric and sympathetic nervous system alterations, with human pediatric data confirming its clinical relevance and suggesting novel therapeutic targets.
A population-based study reveals a significant reduction in impaired awareness of hypoglycemia and severe hypoglycemia in youth with type 1 diabetes from 2002 to 2024, indicating substantial progress in diabetes care and the ongoing need fo
The novel Python-based tool PEPPER enhances electronic medical record searches, efficiently identifying youth with ketosis-prone diabetes, and dramatically reducing manual chart review time without compromising accuracy.
This review synthesizes 20 years of data on pediatric hyperthyroidism, highlighting shifts toward prolonged antithyroid drug therapy, reduced definitive treatments, and rising relapse rates, underscoring the need for individualized long-ter
A longitudinal blood gene-expression study in children found an early neutrophil-driven immune pattern at age 1, followed by a persistent eosinophilic signature from 4.5 to 10.5 years in those who later developed asthma.
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