Ophthalmology
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125 articles · 20 / page
Predictors of 1-Year Visual Outcome in Central-Involving Submacular Hemorrhage Secondary to Neovascular AMD
This study found that younger age, better baseline vision, smaller hemorrhage size, and thicker subfoveal choroid predicted better 1-year visual outcomes after fovea-involving submacular hemorrhage from nAMD or PCV.
Nonexudative Macular Neovascularization in Age-Related Macular Degeneration
In patients with unilateral exudative AMD, double-layer sign on OCT was common, but OCT angiography showed nonexudative macular neovascularization in only about 40% of DLS-positive fellow eyes.
Genomic Risk Profiling May Help Predict Which Patients With Fuchs Endothelial Corneal Dystrophy Progress to Keratoplasty
A 2026 Ophthalmology study suggests that combining CTG18.1 expansion testing with a FECD-specific polygenic risk score can improve prediction of keratoplasty risk across independent cohorts.
Anesthesia-Related Neurologic Risk in Patients of Venezuelan Descent: Implications for Ophthalmology
A rare, severe neurologic complication has been linked to general anesthesia in patients of maternal Venezuelan descent. Ophthalmologists should screen for ancestry and family history, involve anesthesiology early, and consider genetic eval
Small Copy Number-Neutral Intrachromosomal Translocation of PAX6 and Aniridia
Optical genome mapping and long-read sequencing uncovered a tiny balanced rearrangement that separated PAX6 from its control region, explaining classic aniridia after prior testing was negative.
Intraoperative Intravitreal Bevacizumab Extended Trabeculectomy Survival to 3 Years in a Randomized Trial
A double-blind randomized trial found that a single intraoperative intravitreal bevacizumab injection improved 3-year trabeculectomy survival and reduced postoperative medication needs versus placebo.
Delayed Glaucoma Follow-Up Was Usually Not Linked to Visual Field Progression, but Longer Gaps May Matter in More Advanced Disease
In a large retrospective glaucoma cohort, delayed follow-up was common yet was not generally associated with visual field worsening, although longer delays appeared more consequential in eyes with worse baseline visual field loss.
Optimizing Geographic Atrophy Clinical Trial Design: The Role of Run-In Phases, Single-Arm Architectures, and Functional Endpoints
This review synthesizes evidence on improving geographic atrophy trial efficiency through innovative run-in phases, single-arm designs, and superior functional biomarkers like microperimetry to reduce required sample sizes.
GLP-1 Weight-Loss and Diabetes Drugs: What Eye Specialists Say About NAION Risk
A new consensus statement advises cautious, shared decision-making about GLP-1 receptor agonists and NAION risk, noting that current evidence is observational, conflicting, and suggests any absolute risk increase is small.
Persistent Challenges in Managing Monocular Deprivation Amblyopia: A Three-Decade Trend Analysis of Infant Unilateral Cataract Outcomes
This review evaluates 30 years of clinical outcomes for monocular congenital cataracts, revealing stagnant visual acuity results, high surgical burdens, and significant rates of secondary glaucoma and nystagmus despite surgical advances.
Association of FOXC1 Duplications With Juvenile Open-Angle Glaucoma
A multicenter study found FOXC1 duplications in multiple glaucoma families, strongly linked to juvenile open-angle glaucoma with high penetrance and variable eye and subtle systemic features, supporting routine copy-number testing in select
Pigmentary Glaucoma Shows Higher Procedure Use and Worse Early Failure After LTP and MIGS Than Primary Open-Angle Glaucoma
A large IRIS Registry study found that pigmentary glaucoma undergoes more glaucoma procedures than POAG and has higher early failure after LTP and MIGS, with notable racial differences in disease severity.
Tocilizumab Shows Promising Benefits in Glucocorticoid-Resistant Thyroid Eye Disease
In two prospective cohorts of active, glucocorticoid-resistant thyroid eye disease, tocilizumab improved eye inflammation, proptosis, diplopia, and quality of life with acceptable safety, supporting IL-6 blockade as a promising second-line
Genotype-phenotype correlations in RPGRIP1-associated retinal dystrophy in a nationwide Japanese cohort
Study identifies distinct clinical patterns in Japanese patients with RPGRIP1 mutations: Leber congenital amaurosis shows severe early vision loss while achromatopsia features progressive degeneration. Exon 18 deletion emerges as a founder
Web-Based Amblyopia Decision Support Tool
The Amblyopia Navigator offers evidence-based guidance for eye care professionals to improve early detection and treatment of childhood amblyopia, addressing specialist shortages through accessible digital tools.
Clobetasol Propionate Ophthalmic Suspension 0.05%: A New Therapeutic Milestone in Post-Cataract Surgery Inflammation and Pain Management
This review synthesizes clinical evidence for CPN 0.05% (BYQLOVI®), highlighting its rapid efficacy, superior pain resolution, and favorable safety profile compared to traditional ocular steroids following cataract surgery.
Most Patients Reach 20/40 After Cataract Surgery, but the Current MIPS Success Metric May Misclassify Quality and Exclude Nearly Half of Cases
A large multicenter study found that MIPS measure 191 captures high cataract surgery success rates but excludes many patients and may require case-mix adjustment to support fair surgeon comparisons.
Large Multi-Center EMR Cohort Suggests NSAID Exposure Is Associated With Lower Future Risk of Age-Related Macular Degeneration
In a large TriNetX retrospective cohort, prescribed NSAID use was associated with a lower subsequent risk of AMD, including both non-exudative and exudative disease, though residual confounding limits causal inference.
The Impact of Medication Storage Location on Glaucoma Eyedrop Adherence: A Home-Based Assessment Using Electronic Monitoring
Study reveals storing glaucoma eyedrops in kitchens or bathrooms improves adherence by 60-70% compared to bedrooms, with evening doses most frequently missed. Environmental factors like lighting showed minimal impact.
MBD4 Germline Variants Mark a Strong Predisposition to Uveal Melanoma, Supporting Broad Genetic Screening
A large French case series found pathogenic or likely pathogenic germline MBD4 variants in 23 of 896 patients with uveal melanoma, corresponding to a 31-fold relative risk versus the general population.
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